Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less

High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study

“…Also, other parameters related to DNA content abnormalities and genomic instability (DI, 5N‐EC and HI) were consistently higher in young patients. Such findings are in line with previous studies that highlighted possible genetic causes for oral SCC in young individuals, especially for young populations without traditional risk factors 43–46 …”

Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups

“…In addition, in our study, 2 of 4 patients who had regional metastasis and the 1 patient who had distant metastasis were at T4 classification. According to our study, 91.7% of the youngest group patients who experienced recurrence died because of the disease; this extremely high recurrence death rate has also been reported by previous researchers . Younger patients usually already opt for a comparatively comprehensive therapy, but still tend to have higher recurrence rates and the highest recurrence death rate.…”

“…Another issue has been the lack of an exact definition for “young age”; consequently, the grouping of young patients in previous studies was optional and, thus, inconsistent. A wide range of cutoff points from 30‐45 years has been reported in previous studies …”

Oral squamous cell carcinoma in a South African sample: Race/ethnicity, age, gender, and degree of histopathological differentiation

“…[40] While some studies have shown that the prognosis is similar in younger and in older persons, [14,21,41,42] other studies have found that sometimes OSCCs in younger persons are particularly aggressive and are associated with a poor prognosis; [43][44][45][46] yet other studies have reported rather better survival rates in younger persons than in older persons with OSCC. [8,20,47,48] The racial disparities with regard to age, gender, and degree of histopathological differentiation of the OSCCs in our study of a South African population sample are brought about by a complex interaction of factors.…”