Head acceleration event metrics in youth contact sports more dependent on sport than level of play

Lee, Taylor; Lycke, Roy; Auger, Joshua; Music, Jacob; Dziekan, Michael; Newman, Sharlene D.; Talavage, Thomas M.; Leverenz, Larry J.; Nauman, Eric A.

doi:10.1177/0954411920970812

Cited by 7 publications

(2 citation statements)

References 86 publications

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“…These findings are not dependent on athlete sex even after considering differences in hit distribution profiles between football and soccer athletes. 58 At this 50-G threshold, these volumetric findings complement previous detection of cerebrovascular reactivity (CVR) 16 and magnetic resonance spectroscopy (MRS) 15 changes for the asymptomatic CSA population. Further, similar PTA thresholds (e.g., 60 G) have been found to induce functional changes in previous biomarker studies involving this CSA population using MRS 59 and working memory functional MRI (fMRI).…”

Section: Discussionsupporting

confidence: 67%

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Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports

Kashyap

Shenk

Svaldi

et al. 2022

Neurotrauma Reports

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Observations of short-term changes in the neural health of youth athletes participating in collision sports (e.g., football and soccer) have highlighted a need to explore potential structural alterations in brain tissue volumes for these persons. Studies have shown biochemical, vascular, functional connectivity, and white matter diffusivity changes in the brain physiology of these athletes that are strongly correlated with repetitive head acceleration exposure. Here, research is presented that highlights regional anatomical volumetric measures that change longitudinally with accrued subconcussive trauma. A novel pipeline is introduced that provides simplified data analysis on standard-space template to quantify group-level longitudinal volumetric changes within these populations. For both sports, results highlight incremental relative regional volumetric changes in the subcortical cerebrospinal fluid that are strongly correlated with head exposure events greater than a 50-G threshold at the short-term post-season assessment. Moreover, longitudinal regional gray matter volumes are observed to decrease with time, only returning to baseline/pre-participation levels after sufficient (5–6 months) rest from collision-based exposure. These temporal structural volumetric alterations are significantly different from normal aging observed in sex- and age-matched controls participating in non-collision sports. Future work involves modeling repetitive head exposure thresholds with multi-modal image analysis and understanding the underlying physiological reason. A possible pathophysiological pathway is presented, highlighting the probable metabolic regulatory mechanisms. Continual participation in collision-based activities may represent a risk wherein recovery cannot occur. Even when present, the degree of the eventual recovery remains to be explored, but has strong implications for the well-being of collision-sport participants.

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Section: Discussionsupporting

confidence: 67%

“… 27 Lack of consistent localization of these GM volumetric changes is likely attributable to player-specific patterns of mTBI history (location, magnitude, and frequency). 18 , 58 …”

Section: Discussionmentioning

confidence: 99%

Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports

Kashyap

Shenk

Svaldi

et al. 2022

Neurotrauma Reports

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Multimodal Approaches to Preventing Asymptomatic Repetitive Head Injury in Adolescent Athletes

Talavage

Nauman²,

Lee

2021

Concussions in Athletics

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Metabolomic response to collegiate football participation: Pre- and Post-season analysis

Vike

Bari

Stetsiv

et al. 2022

Sci Rep

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Contact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (Pre) and after the last game (Post). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from Pre to Post (P < 0.05 and Q < 0.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P < 0.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate Pre from Post status, and changes in 64 of the 200 metabolites were also associated with HAEs (P < 0.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury.

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Head acceleration event metrics in youth contact sports more dependent on sport than level of play

Cited by 7 publications

References 86 publications

Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports

Normalized Brain Tissue–Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports

Multimodal Approaches to Preventing Asymptomatic Repetitive Head Injury in Adolescent Athletes

Metabolomic response to collegiate football participation: Pre- and Post-season analysis

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