HDL2 interferes with LDL association with arterial proteoglycans: A possible athero-protective effect

Umaerus, M.; Rosengren, Birgitta; Fagerberg, Björn; Hurt-Camejo, Eva; Camejo, Germán

doi:10.1016/j.atherosclerosis.2012.08.040

Cited by 26 publications

(23 citation statements)

References 29 publications

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“…Moreover, the HDL cholesterol/apoAI ratio in serum was reduced in T2D compared with controls, indicating reduced HDL size in T2D. Because large HDL particles have been shown to reduce the affi nity of LDL to proteoglycans ( 29 ), the indications of smaller HDL particles in T2D in this material may cause increased proteoglycan binding and contribute to the lower-than-expected IF-to-serum gradient for LDL cholesterol. However, the HDL/apoAI ratio in IF did not differ between T2D patients and healthy controls.…”

Section: Discussionmentioning

confidence: 97%

“…Total free cholesterol, and free cholesterol in LDL and HDL were signifi cantly reduced in samples from diabetic patients, in both serum (28,29, and 44%) and IF (38, 44, and 33%) ( Table 3 ). Furthermore, the IF-to-serum gradients for free cholesterol in VLDL and LDL were reduced by 21% and 20%, respectively, in the patients ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, it is of interest to note that LDL particles isolated from T2D patients display increased proteoglycan binding ( 26 ). Furthermore, it is also shown that subclasses by guest, on May 11, 2018 www.jlr.org Supplemental Material can be found at:…”

Section: Discussionmentioning

confidence: 99%

“…by guest, on May 11, 2018 www.jlr.org be the critical location where to fully explore our hypothesis. We used a technique that generates IF in blisters formed by mild suction ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…by guest, on May 11, 2018 www.jlr.org of LDL that display increased proteoglycan binding are also more easily taken up by macrophages ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

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Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients

Apro

Parini

Bröijersén

et al. 2015

Journal of Lipid Research

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At a given level of serum cholesterol, patients with T2D have an increased risk of developing atherosclerosis compared with nondiabetic subjects. We hypothesized that T2D patients have an increased interstitial fl uid (IF)-to-serum gradient ratio for LDL, due to leakage over the vascular wall. Therefore, lipoprotein profi les in serum and IF from 35 T2D patients and 35 healthy controls were assayed using fast performance liquid chromatography. The IF-to-serum gradients for VLDL and LDL cholesterol, as well as for apoB, were clearly reduced in T2D patients compared with healthy controls. No such differences were observed for HDL cholesterol. Contrary to our hypothesis, the atherogenic VLDL and LDL particles were not increased in IF from diabetic patients. Instead, they were relatively sparser than in healthy controls. The most probable explanation to our unexpected fi nding is that these lipoproteins are more susceptible to retainment in the extravascular space of these patients, refl ecting a more active uptake by, or adhesion to, tissue cells, including macrophages in the vascular wall. Further studies are warranted to further characterize the mechanisms underlying these observations, which may be highly relevant for the understanding of why the propensity to develop atherosclerosis is increased in T2D.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…by guest, on May 11, 2018 www.jlr.org be the critical location where to fully explore our hypothesis. We used a technique that generates IF in blisters formed by mild suction ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…by guest, on May 11, 2018 www.jlr.org of LDL that display increased proteoglycan binding are also more easily taken up by macrophages ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

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