HDL-Targeting Therapeutics: Past, Present and Future

Zakiev, Emile; Ma, Feng; Sukhorukov, Vasily N.; Kontush, Anatol

doi:10.2174/1381612822666161027153140

Cited by 18 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In spite of positive effects on LDL‐C and triglycerides, we observed a significant reducing effect of ALE on serum HDL‐C concentrations. However, the observed reduction was mild, and it should be noticed that the causal association between pharmacological modulation of HDL‐C levels and cardiovascular risk is uncertain (Zakiev, Feng, Sukhorukov, & Kontush, ). Finally, ALE may exert an indirect effect on the improvement in NAFLD indices, as the body mass index fell in those receiving ALE supplementation, and weight loss is a recognized therapy for NAFLD (Clark, ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of artichoke leaf extract in non‐alcoholic fatty liver disease: A pilot double‐blind randomized controlled trial

Panahi

Kianpour

Mohtashami

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is potentially treatable, though there are few therapeutic agents available. Artichoke leaf extract (ALE) has shown potential as a hepatoprotective agent. This study sought to determine if ALE had therapeutic utility in patients with established NAFLD. In this randomized double-blind placebo-controlled parallel-group trial, 100 subjects with ultrasound-diagnosed NAFLD were randomized to either ALE 600 mg daily or placebo for a 2-month period. NAFLD response was assessed by liver ultrasound and serological markers including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and AST to platelet ratio index (APRI) score. Ninety patients completed the study (49 ALE and 41 placebo) with no side effects reported. ALE treatment compared with placebo: Doppler sonography showed increased hepatic vein flow (p < .001), reduced portal vein diameter (p < .001) and liver size (p < .001), reduction in serum ALT (p < .001) and AST (p < .001) levels, improvement in AST/ALT ratio and APRI scores (p < .01), and reduction in total bilirubin. ALE supplementation reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations (p = .01). This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of artichoke leaf extract in non‐alcoholic fatty liver disease: A pilot double‐blind randomized controlled trial

Panahi

Kianpour

Mohtashami

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Several therapeutic approaches have been developed in order to maintain a proper level of HDL cholesterol. Statins are drugs able to determine a substantial reduction of LDL concentration [31]. Similarly, fibrates can lead to a moderate increase of HDL-C levels ranging from 5 to 15% [32,33].…”

Section: Plos Onementioning

confidence: 99%

Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects

et al. 2020

View full text Add to dashboard Cite

Metabolic Syndrome (MS) is characterized by a low-grade inflammatory state causing an alteration of non-invasive indexes derived from blood count, namely monocyte-to-HDL ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR). We analyse a population of 771 subjects (394 controls and 377 MS patients) to evaluate the best predictive index of MS. The diagnosis of MS was made according to the 2006 criteria of the International Diabetes Federation (IDF). We performed ROC curve analyses to evaluate the best predictor index of MS. MHR cutoff value was used to classify the population in two different groups and to create the outcome variable of the Recursive Partitioning and Amalgamation (RECPAM) analysis. This method is a tree-structured approach that defines "risk profiles" for each group of dichotomous variables. We showed that MHR index is significantly linked to body mass index (BMI), waist circumference, creatinine, C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR). ROC curve defined an MHR cutoff value of 6.4, which was able to identify two patient groups with significant differences in waist circumference, blood pressure, creatinine, estimated glomerular filtration rate and fasting plasma glucose. RECPAM analysis demonstrated that gender, BMI categorization and hyperglycaemia were the most important risk determinants of increased MHR index that can be considered bona fide a useful and easily obtainable tool to suggest the presence of peculiar metabolic features that predict MS.

show abstract

“…Moreover, the elevated HDL-C has been linked to the lower risk of coronary heart diseases due to its involvement in reverse cholesterol transport (Ali et al, 2012;Zakiev et al, 2017). In this study, it is observed that HFD decreased the serum HDL-C, which is markedly increased by the peel extracts of lime, sour orange and pomello at both 250 mg kg −1 and 500 mg kg −1 .…”

Section: Discussionmentioning

confidence: 60%

Anti-hyperlipidemic effects of citrus fruit peel extracts against high fat diet-induced hyperlipidemia in rats

Pallavi

Siddesha

et al. 2021

ijrps

View full text Add to dashboard Cite

The effects of extracts of orange, , lime, citron and sour orange fruit peels (250 and 500 mg kg-1, i.p) were tested in high fat diet-fed rats. The extracts of lime and sour orange peels (250 and 500 mg kg-1, i.p) showed potent effects, as evident by the decreases in total cholesterol (TC), triglycerides (TG), LDL-C, and VLDL-C, in addition to the increases in HDL-C levels. Besides, lime and sour orange peels (250 and 500 mg kg-1) extract significantly decreased LDL-C/HDL-C ratio, while lime, sour orange and peel extracts markedly decreased index. Remarkably, lime peel extract followed by sour orange and orange at 500 mg kg-1 improved hepatic architecture to near normal with less deposition of fat globules and fewer. Altogether, lime and sour orange peel extracts were found to be effective against parameters such as TC, TG, LDL-C, VLDL-C, and TC/HDL-C and LDL-C/HDL-C ratios, and index, in addition to the increased levels of HDL-C. Thus, lime and sour orange peel extracts could be natural supplement in the management of and associated diseases.

show abstract

HDL-Targeting Therapeutics: Past, Present and Future

Cited by 18 publications

References 0 publications

Efficacy of artichoke leaf extract in non‐alcoholic fatty liver disease: A pilot double‐blind randomized controlled trial

Efficacy of artichoke leaf extract in non‐alcoholic fatty liver disease: A pilot double‐blind randomized controlled trial

Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects

Anti-hyperlipidemic effects of citrus fruit peel extracts against high fat diet-induced hyperlipidemia in rats

Contact Info

Product

Resources

About