HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels

Annema, Wijtske; Willemsen, Hilke; Boer, Jan Freark de; Dikkers, Arne; Giet, Markus van der; Nieuwland, Wybe; Kobold, Anneke C. Muller; Pelt, L. Joost van; Slart, Riemer H. J. A.; Horst, Iwan C. C. van der; Dullaart, Robin; Tio, René A.; Tietge, Uwe J. F.

doi:10.1016/j.jacl.2016.08.003

Cited by 55 publications

(61 citation statements)

References 38 publications

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Section: Discussionsupporting

confidence: 93%

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

Thakkar¹,

Vincent²,

Roy³

et al. 2020

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Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with Acute Coronary Syndrome (ACS) and healthy controls. Methods:We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. Paraoxonase and arylesterase activity of PON1 enzyme were assessed by spectrophotometric methods. Results: We recruited 151 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio= 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio= 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio=0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels duringacute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1 , p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

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Section: Discussionsupporting

confidence: 93%

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

Thakkar¹,

Vincent²,

Roy³

et al. 2020

Preprint

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show abstract

“…Our results demonstrate that HDL from ACS patients had lower ability to mediate cholesterol efflux from lipid laden macrophages compared to HDL from healthy subjects. These results are consistent with the results obtained in other studies that compared the cholesterol efflux capacity in ACS immediately after the onset of symptoms [13,14].On the concern of the assay could be that using same amount of apo B depleted serum irrespective of HDL-C levels could affect the measured levels of CEC. However, HDL-C demonstrated no correlation with CEC and even subjects with similar HDL-C had significantly different total macrophage cholesterol efflux capacity [10,15].…”

Section: Discussionsupporting

confidence: 92%

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

et al. 2020

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Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with acute coronary syndrome (ACS) and healthy controls. Methods: We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. PON1 activities toward paraoxon and phenyl acetate were assessed by spectrophotometric methods. Results:We recruited 150 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio = 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio = 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio = 0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels during acute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1, p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

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“…We cannot explain this result at present; however, according to a recent report, HDL function may be impaired in such a patient with ACS [28]. …”

Section: Discussionmentioning

confidence: 71%

Parallel comparison of risk factors between progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome by covariance structure analysis

et al. 2017

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BackgroundIt is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated.ObjectivesWe investigated the differences in risk factors between these conditions using a statistical procedure.MethodsThe study population consisted of 1,029 patients with ischemic heart disease (IHD). We divided the study population into two groups (ACS and non-ACS) and by diseased vessels (organic stenosis). Covariance structure analysis was simultaneously performed in one equation model for determination and comparison of the risk factors for organic stenosis and ACS.ResultsThe analysis revealed that age (standardized regression coefficient, β: 0.206, P < 0.001), male gender (β: 0.126, P < 0.001), HbA1c level (β: 0.109, P < 0.001), HDL level (β: -0.109, P < 0.001) and LDL level (β: 0.127, P = 0.002) were significant for the advancement of organic stenosis. HDL level (β: 0100, P = 0.002) and MDA-LDL level (β: 0.335, P < 0.001) were significant for the onset of ACS, but age, HbA1c and LDL (P = NS or β < 0.1, respectively) were not. Among the risk factors, age, HbA1c and LDL were significantly more strongly associated with organic stenosis than ACS, while MDA-LDL was significantly more strongly associated with ACS than organic stenosis.ConclusionsThe current statistical analysis revealed clear differences among the risk factors between the progression of organic stenosis and the onset of ACS. Among them, the MDA-LDL level should be considered to indicate a substantial risk of ACS.

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HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels

Cited by 55 publications

References 38 publications

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

Parallel comparison of risk factors between progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome by covariance structure analysis

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