HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

Hong, Brian V.; Zheng, Jingyuan; Zivkovic, Angela M.

doi:10.3390/ijms242015305

Cited by 3 publications

(2 citation statements)

References 144 publications

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“…HDL-C may also have negative health effects and show a U-shaped curve with it. Simple measurement of HDL-C concentration does not yield information about HDL function ( 57 ) and measurement of “dysfunctional” HDL may be an alternative therapeutic target ( 58 ). Therefore, lipid concentrations may be a more distal marker of elevated risk for depression.…”

Section: Discussionmentioning

confidence: 99%

Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators

Yang,

Lin,

Cai

et al. 2024

Front. Psychiatry

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BackgroundPrenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin supplement intake, and clinical blood indicators.MethodsThis study comprised 221 pregnant women, categorized into PDS and non-PDS groups based on the Edinburgh postnatal depression scale. The participants were divided into training and test sets according to their enrollment time. We conducted logistic regression analysis to identify risk factors, and employed liquid chromatography/high resolution mass spectrometry-based serum metabolome analysis to identify metabolic biomarkers. Multiple factor analysis was used to combine risk factors, clinical blood indicators and key metabolites, and then a nomogram was developed to estimate the probability of PDS.ResultsWe identified 36 important differential serum metabolites as PDS biomarkers, mainly involved in amino acid metabolism and lipid metabolism. Multivitamin intake works as a protective factor for PDS. The nomogram model, including multivitamin intake, HDL-C and three key metabolites (histidine, estrone and valylasparagine), exhibited an AUC of 0.855 in the training set and 0.774 in the test set, and the calibration curves showed good agreement, indicating that the model had good stability.ConclusionOur approach integrates multiple models to identify metabolic biomarkers for PDS, ensuring their robustness. Furthermore, the inclusion of dietary factors and clinical blood indicators allows for a comprehensive characterization of each participant. The analysis culminated in an intuitive nomogram based on multimodal data, displaying potential performance in initial PDS risk assessment.

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Section: Discussionmentioning

confidence: 99%

Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators

Yang,

Lin,

Cai

et al. 2024

Front. Psychiatry

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“…According to the design ideas of the "Guangxi Bama Panyang River Basin Health Care, Longevity and Health Industry Development Plan (2012-2020)" issued by the autonomous region government, efforts are made to develop eight series of health care industries. Among these, entities that amalgamate health care and geriatric assistance encompass the sector of health care and elderly care services, as well as the manufacture of products pertinent to health care and elderly care, among other components (Hong et al, 2023;Tan and Zhou, 2022).…”

Section: Introductionmentioning

confidence: 99%

Research on Tourist Satisfaction and Behavioral Intention in Ecological Health Tourism Activities in Bama, Guangxi Based on Structural Equation Model

GE,

CHEN

2024

GTG

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This study endeavors to delve into the intricacies of tourist contentment and proclivities in the realm of ecological health tourism activities within Bama, Guangxi. An exploration of the intricate structural relationships is undertaken, unraveling the quintet of variables encompassing tourists' engagement in Bama's ecological health tourism - namely, the effects of activities, the experiential facet of activities, the pecuniary dimension of activities, coupled with tourist satisfaction and behavioral intent. Employing the methodological framework of constructing a structural equation model, this study leverages IBM SPSS 23.0 software to execute correlation analyses across various variables, including demographic information statistics, reliability and validity metrics. Survey research orbits around the quintet of variables. The findings illuminate that the experiential tapestry woven by tourists partaking in ecological health tourism activities exerts a conspicuously affirmative influence on both their satisfaction and behavioral intentions. Conversely, the financial investment made by tourists in ecologi cal health tourism activities manifests a counteractive impact on their satisfaction and behavioral intentions. Evidently, heightened tourist activity experiences and diminished costs conduce to the facilitation of tourists' aspirations for individualistic tourism activities, thereby enhancing travel satisfaction and behavioral intent. Nevertheless, the potency of tourists' activity effe cts on tourist satisfaction remains suboptimal. Consequently, it is proffered that the propagation of health care paradigms be fortified, coupled with the augmentation of activity experience design. Further, the optimization of cost structures and the enhancement of resource utilization efficiency are recommended, alongside ameliorating activity effects and steering behavioral intent. This comprehensive approach is anticipated to immerse tourists more profoundly into the local ethos of longevity culture, thereby fostering the robust and sustainable evolution of longevity tourism in Bama.

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The Nonlinear Relationship Between High-Density Lipoprotein and Changes in Pulmonary Structure Function and Pulmonary Function in COPD Patients in China

Wen,

Wu,

Deng

et al. 2024

COPD

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Background:The previous findings on the correlation between spirometry and high-density lipoprotein (HDL) cholesterol are intriguing yet conflicting. The aim of this research is to evaluate the relationship between HDL levels and spirometry as well as imaging parameters in patients with chronic obstructive pulmonary disease (COPD) in China. Methods: This study encompasses a total of 907 COPD patients. Participants with complete data from questionnaire interviews, lipid profile examinations, spirometry testing, and computed tomography (CT) scans were included in the analysis. A generalized additive model was employed to identify the non-linear relationship between HDL levels and both spirometry and imaging parameters. In the presence of non-linear correlations, segmented linear regression model was applied to ascertain threshold effects. Results: After adjusting for various factors, we found a non-linear correlation between HDL levels and spirometry/imaging parameters, with an inflection point at 4.2 (66 mg/dL). When Ln (HDL) was below 4.2, each unit increase correlated significantly with reduced post-bronchodilator FEV 1 (0.32L, 95% CI: 0.09-0.55), decreased predicted FEV 1 % (11.0%, 95% CI: 2.7-19.3), and lowered FEV 1 /FVC (8.0%, 95% CI: 4.0-12.0), along with notable increases in Ln (LAA −950 ) by 1.20 (95% CI: 0.60-1.79) and Ln (LAA −856 ) by 0.77 (95% CI: 0.37-1.17). However, no significant associations were observed when Ln (HDL) was greater than or equal to 4.2. Conclusion: A non-linear correlation existed between HDL levels with lung function and CT imaging in COPD patients. Prior to reaching 66 mg/dL, an elevation in HDL was significantly associated with impaired lung function, more severe gas trapping and emphysema.

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HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

Cited by 3 publications

References 144 publications

Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators

Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators

Research on Tourist Satisfaction and Behavioral Intention in Ecological Health Tourism Activities in Bama, Guangxi Based on Structural Equation Model

The Nonlinear Relationship Between High-Density Lipoprotein and Changes in Pulmonary Structure Function and Pulmonary Function in COPD Patients in China

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