2016
DOI: 10.1186/s40064-016-3145-x
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Abstract: ObjectivesTo investigate if HDL cholesterol (HDL-c) could be a biomarker of the degree of severity according to prognostic prediction scores in community-acquired pneumonia (CAP) or the development of clinical complications such as pleural effusion.MethodsWe included in a retrospective study 107 patients admitted to the hospital that fulfilled diagnostic criteria for CAP between the 30th October 2011 and 1st September 2012. HDL-c levels at admission, CAP prognosis scores (PSI and CURB65) and clinical outcomes … Show more

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Cited by 12 publications
(12 citation statements)
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“…Infectious diseases are usually associated with low HDL cholesterol (HDL-C) concentrations and sometimes with low LDL cholesterol (LDL-C) concentrations, while triglyceride levels are typically maintained or even increased 6 , 11 . Low HDL-C levels have been proposed as a risk biomarker for different infections 12 . Regarding the SARS-CoV-2 infection, low LDL-C, HDL-C and triglyceride (TG) levels have been described to be associated with an increasing infection severity 6 , and a role for these lipids in immune mechanisms has been suggested 13 .…”
Section: Introductionmentioning
confidence: 99%
“…Infectious diseases are usually associated with low HDL cholesterol (HDL-C) concentrations and sometimes with low LDL cholesterol (LDL-C) concentrations, while triglyceride levels are typically maintained or even increased 6 , 11 . Low HDL-C levels have been proposed as a risk biomarker for different infections 12 . Regarding the SARS-CoV-2 infection, low LDL-C, HDL-C and triglyceride (TG) levels have been described to be associated with an increasing infection severity 6 , and a role for these lipids in immune mechanisms has been suggested 13 .…”
Section: Introductionmentioning
confidence: 99%
“…A previous study by Saballs et al. [ 1 ] has also shown that one of the components in dyslipidemia, which is high-density lipoprotein (HDL) can predict the presence of respiratory disease and the clinical outcome of community-acquired pneumonia (CAP). However, the association between dyslipidemia and COVID-19 has not yet been established.…”
mentioning
confidence: 99%
“…Therefore, it has been determined to play a role in body defense [12,13]. Additionally, HDL has been reported to have anti-inflammatory, antioxidant, and immunomodulatory effects [14]. LDL, on the other hand, has been shown to facilitate the clearance of bacterial toxins in sepsis [15].…”
Section: Discussionmentioning
confidence: 99%
“…LDL and HDL levels are known to decrease in response to oxidation, infection, and inflammation [16]. Some previous studies evaluated patients hospitalized for CAP and indicated a strong correlation between reduced HDL concentration and causes of clinical worsening such as hemodynamic instability and pleural effusion [14,17].…”
Section: Discussionmentioning
confidence: 99%