HDL-c levels predict the presence of pleural effusion and the clinical outcome of community-acquired pneumonia

Saballs, M.; Parra, Sandra; Sahun, P.; Pellejà, J.; Feliu, M.; Vasco, C.; Gumà, Josep; Borrás, Joan; Castro, Antoni

doi:10.1186/s40064-016-3145-x

Cited by 13 publications

(12 citation statements)

References 39 publications

(49 reference statements)

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“…Infectious diseases are usually associated with low HDL cholesterol (HDL-C) concentrations and sometimes with low LDL cholesterol (LDL-C) concentrations, while triglyceride levels are typically maintained or even increased 6 , 11 . Low HDL-C levels have been proposed as a risk biomarker for different infections 12 . Regarding the SARS-CoV-2 infection, low LDL-C, HDL-C and triglyceride (TG) levels have been described to be associated with an increasing infection severity 6 , and a role for these lipids in immune mechanisms has been suggested 13 .…”

Section: Introductionmentioning

confidence: 99%

Low HDL and high triglycerides predict COVID-19 severity

Masana

Correig

Ibarretxe

et al. 2021

Sci Rep

147

134

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Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.

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Section: Introductionmentioning

confidence: 99%

Low HDL and high triglycerides predict COVID-19 severity

Masana

Correig

Ibarretxe

et al. 2021

Sci Rep

147

134

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“…A previous study by Saballs et al. [ 1 ] has also shown that one of the components in dyslipidemia, which is high-density lipoprotein (HDL) can predict the presence of respiratory disease and the clinical outcome of community-acquired pneumonia (CAP). However, the association between dyslipidemia and COVID-19 has not yet been established.…”

mentioning

confidence: 99%

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection

Hariyanto

Kurniawan

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

104

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Background and aims The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing. The identification of risk factors for severe outcomes is important. Dyslipidemia has been shown as a long-known risk factor for cardiovascular disease. The aim of this study is to analyze the potential association between dyslipidemia and the severity of COVID-19 infection. Methods We systematically searched the PubMed database using specific keywords related to our aims until July 9th, 2020. All articles published on COVID-19 and dyslipidemia were retrieved. Statistical analysis was done using Review Manager 5.4 software. Results A total of 7 studies with a total of 6922 patients were included in our analysis. Our meta-analysis showed that dyslipidemia is associated with severe COVID-19 infections [RR 1.39 (95% CI 1.03–1.87), p = 0.03, I 2 = 57%, random-effect modelling]. Conclusion Dyslipidemia increases the risk of the development of severe outcomes from COVID-19 infections. Patients with dyslipidemia should be monitored closely to minimize the risk of COVID-19.

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“…Therefore, it has been determined to play a role in body defense [12,13]. Additionally, HDL has been reported to have anti-inflammatory, antioxidant, and immunomodulatory effects [14]. LDL, on the other hand, has been shown to facilitate the clearance of bacterial toxins in sepsis [15].…”

Section: Discussionmentioning

confidence: 99%

“…LDL and HDL levels are known to decrease in response to oxidation, infection, and inflammation [16]. Some previous studies evaluated patients hospitalized for CAP and indicated a strong correlation between reduced HDL concentration and causes of clinical worsening such as hemodynamic instability and pleural effusion [14,17].…”

Section: Discussionmentioning

confidence: 99%

The role of serum HLD, LDL, and uric acid levels in predicting the prognosis of community-acquired pneumonia

Hoşgün¹,

Akpınar²,

Gülensoy³

et al. 2022

Pamukkale Medical Journal

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Community-acquired pneumonia (CAP) leads to inflammation and oxidative stress as a result in infection. In the present study, we aimed to investigate the relationship between initial serum high-density lipoprotein (HDL), low-density lipoprotein (HDL), and uric acid levels on short-term (30-day) changes in the course of CAP. Materials and methods:The retrospective study included 113 patients with CAP that received inpatient care between 2012 and 2018.The HDL, LDL and uric acid values in the blood received in hospital admission were examined for their relationship with shortterm mortality and correlation with hospitalization. Results:The 113 patients comprised 71 (62.8%) men and 42 (37.2%) women with a mean age of 74±11 years. Of the 113 patients, 30-day mortality occurred in 12 (10.6%) patients. Of the 113 patients, 17 (16.5%) patients were hospitalized in ICU. All cases detected as mortality were followed in ICU. Normal ranges of HDL, LDL, and uric acid concentrations were accepted as 40-70 mg/dL, 60-130 mg/dL, and 1.8-8 mg/dL, respectively. The mean serum LDL, HDL, and uric acid levels were 97.95±42.11 (range, 26-271) mg/dL, 40.94±13.70 (range, 5.10-83.20) mg/dL, and 5.99±2.18 (range, 1.40-13.20) mg/dL, respectively. HDL and LDL levels were found to be insignificant predictors of 30-day mortality (p=0.482 and p=0.725, respectively). Similarly, serum HDL, LDL, and uric acid levels were found to be insignificant predictors of the duration of hospitalization and ICU requirement. On the other hand, multivariate logistic regression analysis indicated that uric acid concentration was a protective factor for 30-day mortality (OR, 0.694; 95% Cl, 0.478-0.989, p=0.048), whereby increased uric acid concentration was found to decrease the risk of mortality and reduced uric acid concentration was found to increase the risk of mortality by 1.44 times (1/0.694). Conclusion:We suggest that monitoring uric acid levels with serial measurements in patients with CAP may be useful for predicting the short term prognosis. Further prospective multicentric studies with larger patient series are needed to investigate the correlation between serum uric acid levels and clinical risk scores.

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HDL-c levels predict the presence of pleural effusion and the clinical outcome of community-acquired pneumonia

Cited by 13 publications

References 39 publications

Low HDL and high triglycerides predict COVID-19 severity

Low HDL and high triglycerides predict COVID-19 severity

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection

The role of serum HLD, LDL, and uric acid levels in predicting the prognosis of community-acquired pneumonia

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