HDL biogenesis and functions: Role of HDL quality and quantity in atherosclerosis

Tsompanidi, Eirini M.; Brinkmeier, Maria S.; Fotiadou, Elisavet H.; Giakoumi, Smaragda M.; Kypreos, Kyriakos E.

doi:10.1016/j.atherosclerosis.2009.05.034

Cited by 147 publications

(133 citation statements)

References 106 publications

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“…By reverse cholesterol transport HDL particles accept cholesterol from the periphery, such as arterial wall cells, and deliver it to the liver. Reverse cholesterol transport is the major mechanism of antiatherogenic effects of HDL (24). In addition, a hypothesis that smaller HDL particles have diminished anti-atherogenic capacity in the conditions associated with dyslipidemia, inflammation, and enhanced oxidative stress was also confirmed (24).…”

Section: Discussionmentioning

confidence: 95%

Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity

Bekhet¹,

Vekić²,

Zeljković³

et al. 2017

Turk J Med Sci

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Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and highdensity lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods:We included 42 obese children, aged 14.2 ± 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods.Results: Compared with obese children with Apgar ≥ 9, the group with Apgar < 9 had significantly higher percentages of small, dense LDL particles (P < 0.05), due to reduced LDL I (P < 0.01) and increased LDL III subclasses (P < 0.05). Birth weight was positively associated with the proportions of LDL I particles (P < 0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P < 0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P < 0.01) and lower proportion of HDL 2a particles (P < 0.05) than their ≥3 months breastfed peers. Conclusion:The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.

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Section: Discussionmentioning

confidence: 95%

Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity

Bekhet¹,

Vekić²,

Zeljković³

et al. 2017

Turk J Med Sci

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“…RCT is believed to be one of the main explanations for the HDL-c atheroprotective effect. Through this pathway, HDL prevents the excessive accumulation of cholesterol in the arterial wall (13). Additionally, HDL has antioxidative, anti-inflammatory and antithrombotic effects (13).…”

Section: Discussionmentioning

confidence: 99%

“…Beyond quantity, other properties of HDL are very important for atheroprotection (13). The best documented property (9) is the ability of HDL to promote the unloading of excessive cholesterol from peripheral tissues and its transport to the liver for catabolism, a process which is known as reverse cholesterol transport (RCT) (13).…”

Section: Discussionmentioning

confidence: 99%

Severe HDL-c reduction during rosiglitazone therapy in an obese woman with type 2 diabetes

Almeida¹,

Fedrizzi²,

Fedrizzi³

et al. 2010

Arq Bras Endocrinol Metab

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SUMMARYTreatment with rosiglitazone has been associated with severe paradoxical HDL-c reductions. To our knowledge, there are very few reports of this reaction occurring when patients are treated without the combination of a fibrate. A case of severe HDL-c lowering in a patient treated with rosiglitazone without a fibrate is presented. The patient has been treated at a private practice clinic in southern Brazil. A 64-year-old woman with a 2-year history of type 2 diabetes mellitus was referred to her endocrinologist in June 2008. Rosiglitazone 4 mg q.d. was prescribed. Nine months later, the patient experienced a 90.90% decrease of her HDL-c levels. Rosiglitazone was withdrawn and the HDL-c returned to baseline. This paradoxical HDL-c reduction is a potentially severe adverse event. Patients prescribed rosiglitazone should have their HDL-c levels measured before and during therapy. Arq Bras Endocrinol Metab. 2010;54(7):663-7 SUMÁRIOO tratamento com rosiglitazona tem sido associado a reduções paradoxais e severas no HDL-c. Há muito poucos relatos dessa reação ocorrendo em pacientes tratados com rosiglitazona sem a combinação com um fibrato. Apresentou-se um caso de diminuição severa no HDL-c em uma paciente tratada com rosiglitazona sem fibrato associado. A paciente foi tratada em uma clínica privada no Sul do Brasil. Uma mulher de 64 anos com história de diabetes melito tipo 2 há 2 anos foi encaminhada ao seu endocrinologista em junho de 2008. Prescreveu-se rosiglitazona 4 mg uma vez ao dia. Nove meses depois, a paciente teve redução de 90,90% em seus níveis de HDL-c. A rosiglitazona foi retirada e o HDL-c retornou aos níveis prévios. Essa redução paradoxal do HDL-c é um evento adverso potencialmente severo. Pacientes aos quais se prescreve rosiglitazona devem ter seus níveis de HDL-c medidos antes e durante o tratamento.

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“…The Framingham study (HDL concentrations predicting cardiovascular risk) shows that 40% of events occurred in people with normal HDL levels [6]. In some instances increased plasma HDL levels can result from reduced catabolism due to blockage in the dynamic flow of HDL lipids from peripheral tissues to the liver [7]. In this scenario, measuring HDL levels alone may not be accurate in assessing the cardiovascular risk.…”

Section: Introductionmentioning

confidence: 94%

“…Free cholesterol, phospholipids and apolipoproteins (apo AI, AII, C,E, AIV, J and D) form an outer amphipathic layer. Apo AI is the principal protein, determines the atheroprotective function of HDL through its interaction with scavenger receptor class B type 1(SR-B1) [7]. Mature spherical HDL contains 45-55% (mass %) apoproteins, 26-32% phospholipids, 15-20% esterified cholesterol, 3-5% free cholesterol and approximately 5% triglycerides.…”

Section: Structure Of Hdlmentioning

confidence: 99%

High density lipoprotein – quality and function

Gayathri

2011

Ceylon Med. J.

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HDL biogenesis and functions: Role of HDL quality and quantity in atherosclerosis

Cited by 147 publications

References 106 publications

Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity

Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity

Severe HDL-c reduction during rosiglitazone therapy in an obese woman with type 2 diabetes

High density lipoprotein – quality and function

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