HDL Atheroprotection by Aerobic Exercise Training in Type 2 Diabetes Mellitus

Ribeiro, I. C. D.; Iborra, Rodrigo Tallada; Neves, Manoel; Lottenberg, Simão Augusto; Charf, A.M.; Nunes, V.S.; Negräo, Carlos Eduardo; Nakandakare, Edna Regina; Quintão, Eder Carlos Rocha; Passarelli, Marisa

doi:10.1249/mss.0b013e3181632d2d

Cited by 37 publications

(19 citation statements)

References 43 publications

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“…As shown in ESM Table 1, across 20 interventions of aerobic exercise training, [8,9,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] the mean exercise frequency was three sessions per week, mean session duration was 48 min (not including warm-up and cool down), and mean exercise intensity was 74% of the HR max . In six trials (33%), exercise intensity was transformed from submaximal rates of V : O 2peak to the corresponding percentages of HR max .…”

Section: Resultsmentioning

confidence: 99%

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

et al. 2012

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Aims/hypothesis Supervised exercise programmes improve glycaemic control in type 2 diabetes, but training characteristics associated with reduction in HbA 1c remain unclear. We conducted a systematic review with meta-regression analysis of randomised clinical trials (RCTs) assessing the association between intensity and volume of exercise training (aerobic, resistance or combined) and HbA 1c changes in patients with type 2 diabetes. Methods Five electronic databases were searched to retrieve RCTs of at least 12 weeks' duration, consisting of supervised exercise training vs no intervention, that reported HbA 1c changes and exercise characteristics. Two independent reviewers conducted study selection and data extraction.Results Twenty-six RCTs (2,253 patients) met the inclusion criteria. In multivariate analysis, baseline HbA 1c and exercise frequency explained nearly 58% of between-study variance. Baseline HbA 1c was inversely correlated with HbA 1c reductions after the three types of exercise training. In aerobic training, exercise volume (represented by frequency of sessions) was associated with changes in HbA 1c (weighted r0−0.64), while no variables were correlated with glycaemic control induced by resistance training. In combined training, weekly volume of resistance exercise explained heterogeneity in multivariate analysis and was associated with changes in HbA 1c levels (weighted r0−0.70). Conclusions/interpretation Reduction in HbA 1c is associated with exercise frequency in supervised aerobic training, and with weekly volume of resistance exercise in supervised combined training. Therefore, exercise volume is a major determinant of glycaemic control in patients with type 2 diabetes.

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Section: Resultsmentioning

confidence: 99%

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

et al. 2012

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“…Accumulating evidence supports the recommendation of regular physical activity for the prevention and treatment of diabetes and other chronic diseases that present a constant proinflammatory status [19]. The practice of regular physical activity is known to bring health benefits such as increased insulin sensitivity, glycaemic control, decrease of body weight and percentage of body fat, lower blood pressure and reduction of overall risk of vascular disease [6,8,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Moderate exercise improves leucocyte function and decreases inflammation in diabetes

Belotto

Magdalon

Rodrigues

et al. 2010

Clinical and Experimental Immunology

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SummaryThe genesis and progression of diabetes occur due in part to an uncontrolled inflammation profile with insulin resistance, increased serum levels of free fatty acids (FFA), proinflammatory cytokines and leucocyte dysfunction. In this study, an investigation was made of the effect of a 3-week moderate exercise regimen on a treadmill (60% of VO2max, 30 min/day, 6 days a week) on inflammatory markers and leucocyte functions in diabetic rats. The exercise decreased serum levels of tumour necrosis factor (TNF)-a (6%), cytokineinduced neutrophil chemotactic factor 2 alpha/beta (CINC-2a/b) (9%), interleukin (IL)-1b (34%), IL-6 (86%), C-reactive protein (CRP) (41%) and FFA (40%) in diabetic rats when compared with sedentary diabetic animals. Exercise also attenuated the increased responsiveness of leucocytes from diabetics when compared to controls, diminishing the reactive oxygen species (ROS) release by neutrophils (21%) and macrophages (28%). Exercise did not change neutrophil migration and the proportion of neutrophils and macrophages in necrosis (loss of plasma membrane integrity) and apoptosis (DNA fragmentation). Serum activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were not modified in the conditions studied. Therefore, physical training did not alter the integrity of muscle cells. We conclude that moderate physical exercise has marked anti-inflammatory effects on diabetic rats. This may be an efficient strategy to protect diabetics against microorganism infection, insulin resistance and vascular complications.

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“…Potentially more important than HDL-C levels, however, is how exercise may improve HDL function. For example, exercise has been reported to increasing the cholesterol efflux capacity of HDL isolated from metabolic syndrome patients (Casella-Filho et al, 2011), although this was not observed in a previous study (Ribeiro et al, 2008). In another study, exercise training in chronic heart failure (CHF) patients increased the ability of their HDL to promote NO production and flow-mediated dilatation (Adams et al, 2013).…”

Section: Hdl and Inflammationmentioning

confidence: 92%

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

2014

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Cerebrovascular dysfunction significantly contributes to the clinical presentation and pathoetiology of Alzheimer's disease (AD). Deposition and aggregation of β-amyloid (Aβ) within vascular smooth muscle cells leads to inflammation, oxidative stress, impaired vasorelaxation, and disruption of blood-brain barrier integrity. Midlife vascular risk factors, such as hypertension, cardiovascular disease, diabetes, and dyslipidemia, increase the relative risk for AD. These comorbidities are all characterized by low and/or dysfunctional high-density lipoproteins (HDL), which itself is a risk factor for AD. HDL performs a wide variety of critical functions in the periphery and CNS. In addition to lipid transport, HDL regulates vascular health via mediating vasorelaxation, inflammation, and oxidative stress and promotes endothelial cell survival and integrity. Here, we summarize clinical and preclinical data examining the involvement of HDL, originating from the circulation and from within the CNS, on AD and hypothesize potential synergistic actions between the two lipoprotein pools.

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HDL Atheroprotection by Aerobic Exercise Training in Type 2 Diabetes Mellitus

Abstract: Our results show that aerobic exercise training in diabetes mellitus improves the HDL efficiency against LDL oxidation and favors HDL maturation. These findings were independent of changes in insulin resistance and of the rise of plasma HDL cholesterol concentration.

Cited by 37 publications

References 43 publications

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

Moderate exercise improves leucocyte function and decreases inflammation in diabetes

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

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