HDL and arteriosclerosis: beyond reverse cholesterol transport

Nofer, Jerzy–Roch; Kehrel, Beate E.; Fobker, Manfred; Levkau, Bodo; Assmann, Gerd; Eckardstein, Arnold von

doi:10.1016/s0021-9150(01)00651-7

Cited by 535 publications

(376 citation statements)

References 191 publications

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“…That PC can serve as a source of TG was previously shown in rat hepatocytes for which incubation with [ 3 H]oleic acid increased the amount of radiolabeled cellular and secreted TG with a concomitant loss of labeled PC (36). In addition, when cells were prelabeled with 1,2-di [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]palmitoylphosphatidylcholine, part of the radiolabel was secreted as TG. More recently, we have shown that 50% of LDL-PC that is taken up by mouse hepatocytes is converted into TG (14).…”

Section: Discussionmentioning

confidence: 99%

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

Veen

Lingrell

Vance

2012

Journal of Biological Chemistry

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Background: Most hepatic triacylglycerols are believed to originate from fatty acids released from adipose tissue. Results: Lipoprotein phosphatidylcholine is taken up by the liver and converted into triacylglycerols in vivo. Conclusion: Lipoprotein-associated phosphatidylcholine is a quantitatively significant source of hepatic triacylglycerols. Significance: The role of lipoprotein phosphatidylcholine should now be factored into our thinking about the development of hepatic steatosis.

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Section: Discussionmentioning

confidence: 99%

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

Veen

Lingrell

Vance

2012

Journal of Biological Chemistry

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“…25 HDL can also reverse endothelial dysfunction, inhibit LDL oxidation, stimulate endothelial cell proliferation and prostacyclin generation. 26 Lowered HDL level diminishes these benefits and increases the risk of thrombosis. On the contrary Ullrich, Aurbach and Drobik 22 indicated that both hyperlipidaemia and atherogenic risk factors are not major pathological importance in SSNHL.…”

Section: Discussionmentioning

confidence: 99%

Status of Lipid Profile and Uric Acid in Sudden Sensorineural Hearing Loss

Panda¹

2017

jmscr

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“…Lipoproteins are object of extensive research for last 40 years due to their active role in atherogenesis (Nofer et al 2002;Barter et al 2003). The spherical particles consist of polar lipid monolayer which encapsulates apolar lipids (Gotto 1987).…”

Section: Introductionmentioning

confidence: 99%

Location of PRODAN in lipid layer of HDL particle: a Raman study

et al. 2008

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FT Raman spectroscopy has been applied to determine the location of PRODAN within HDL and to investigate its influence on the structure of the particle. The complex spectra of HDL and HDL labeled with PRODAN were divided into three regions according to the wave numbers, and adherent spectra were compared separately. Additionally, recorded spectra of protein and lipid fractions of HDL were used as a support for the assignment of particular vibrations in intact particles. In high frequency region, the shift in vibrational frequencies of CH 3 groups but almost negligible shift of CH 2 groups suggests that PRODAN is situated at the water/lipid interface in the vicinity of the protein. The statement is supported by the observed influence of PRODAN on particular lipid vibrations of phospholipids head-groups.In the fingerprint region, the influence of PRODAN is observed as the slight change in -strand secondary structure of apolipoprotein and strongly reduced vibrations of the acyl chain in lipids. That additionally confirms that PRODAN mainly interacts with the lipid domain of the particle. In the low frequency region, the lack of change in Tyr Fermi resonance doublet and only slight differences in the pattern of CS and SS stretching vibrations in labeled HDL confirms that PRODAN has no influence on structure of apolipoprotein embeddd in lipid domain. The main conclusions drawn from the vibrational spectra of HDL with and without PRODAN clearly confirm that PRODAN induces negligible changes in HDL structure and hence is reliable fluorescent label for the structural analysis.

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HDL and arteriosclerosis: beyond reverse cholesterol transport

Cited by 535 publications

References 191 publications

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

Status of Lipid Profile and Uric Acid in Sudden Sensorineural Hearing Loss

Location of PRODAN in lipid layer of HDL particle: a Raman study

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