HDL and apolipoprotein A-I protect erythrocytes against the generation of procoagulant activity.

Epand, Richard M.; Stafford, Alan R.; Leon, Bryan T. C.; Lock, Peretz; Tytler, Ewan M.; Segrest, Jere P.; Anantharamaiah, G.M.

doi:10.1161/01.atv.14.11.1775

Cited by 80 publications

(39 citation statements)

References 30 publications

(16 reference statements)

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“…Possible explanations include the fact that HDL-C has antioxidant and antiinflammatory properties (6, 7), attenuates endothelial dysfunction (8,9), has anticoagulant effects (10,11), and enhances the half-life of prostacyclin (12)(13)(14). The antiinflammatory properties of HDL-C may be particularly relevant here, because we observed systemic inflammation and endothelial activation in patients with PAH with low HDL-C levels (Table 8).…”

Section: Discussionmentioning

confidence: 85%

“…High-density lipoprotein cholesterol (HDL-C) is associated with a lower risk of coronary heart disease (4,5).The underlying mechanisms behind this protective effect include stimulation of reverse cholesterol transport, antioxidant and antiinflammatory properties (6,7), attenuation of endothelial dysfunction (8,9), anticoagulant effects (10,11), and enhancement of prostacyclin half-life (12)(13)(14). Interestingly, except for reverse cholesterol transport, derangements in all of these mechanisms have been implicated in the pathobiology of PAH.…”

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confidence: 99%

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Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

Heresi¹,

Aytekin²,

Newman³

et al. 2010

Am J Respir Crit Care Med

114

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Rationale: High-density lipoprotein cholesterol (HDL-C) promotes healthy vascular function, and it is decreased in insulin resistance. Insulin resistance predisposes to pulmonary vascular disease. Objectives: We hypothesized that HDL-C is associated with clinical outcomes in pulmonary arterial hypertension (PAH). Methods: Plasma HDL-C concentrations were measured in 69 patients with PAH (age, 46.7 6 12.9 yr; female, 90%) and 229 control subjects (age, 57 6 13 yr; female, 48%). Clinical outcomes of interest included hospitalization for PAH, lung transplantation, and all-cause mortality. Survival and time to clinical worsening curves were derived by the Kaplan-Meier method. Cox regression modeling of outcome versus HDL-C with individual covariate adjustments was performed. Measurement and Main Results: HDL-C was low in subjects with PAH compared with control subjects (median, interquartile range: PAH: 36, 29-40 mg/dl; control subjects: 49, 40-60 mg/dl; P , 0.001). An HDL-C level of 35 mg/dl discriminated survivors from nonsurvivors, with a sensitivity of 100% and specificity of 60%. After a median follow-up of 592 days, high HDL-C was associated with decreased mortality (hazard ratio for every 5-mg/dl increase in HDL-C, 0.643; 95% confidence interval, 0.504-0.822; P 5 0.001) and less clinical worsening (hazard ratio for every 5-mg/dl increase in HDL-C, 0.798; 95% confidence interval, 0.663-0.960; P 5 0.02). HDL-C remained a significant predictor of survival after adjusting for cardiovascular risk factors, C-reactive protein, indices of insulin resistance, and severity of PAH (all P , 0.05). Conclusions: Low plasma HDL-C is associated with higher mortality and clinical worsening in PAH. This association does not appear to be explained by underlying cardiovascular risk factors, insulin resistance, or the severity of PAH.

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Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

Heresi¹,

Aytekin²,

Newman³

et al. 2010

Am J Respir Crit Care Med

114

View full text Add to dashboard Cite

show abstract

“…Apo A-I, its amphipathic peptide analogues and HDLs were also shown to protect erythrocytes against the generation of procoagulant activity (Epand et al 1994). HDL 2 subfraction was reported to be inversely correlated with erythrocyte aggregation in hypercholesterolemic patients (Razavian et al 1994).…”

Section: Antithrombotic Actionsmentioning

confidence: 99%

“…The mechanisms by which HDL 2 may prevent RBC aggregability have not been elucidated, but this effect is relevant in small-sized arteries where increased blood viscosity may trigger clot formation. Apo A-I, its amphipathic peptide analogues and HDLs were also shown to protect erythrocytes against the generation of procoagulant activity (Epand et al 1994). HDLs may inhibit phospholipid flip-flop and the associated procoagulant activity.…”

Section: Antithrombotic Actionsmentioning

confidence: 99%

High-Density Lipoproteins in Stroke

Meilhac

2014

High Density Lipoproteins

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“…For example, they bind lipopolysaccharide, 5 stimulate endothelial cell movement, 6 inhibit the synthesis of plateletactivating factor by endothelial cells, 7 and protect erythrocytes against the generation of procoagulant activity. 8 HDLs stimulate prostacyclin synthesis by endothelial cells. 9 They also bind prostacyclin and thus prolong its half-life.…”

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confidence: 99%

Anti-Inflammatory Properties of HDL

Ansell

Navab

Watson

et al. 2004

Rev Endocr Metab Disord

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Abstract-There are several well-documented functions of high-density lipoprotein (HDL) that may explain the ability of these lipoproteins to protect against atherosclerosis. The best recognized of these is the ability of HDL to promote the efflux of cholesterol from cells. This process may minimize the accumulation of foam cells in the artery wall. However, HDL has additional properties that may also be antiatherogenic. For example, HDL is an effective antioxidants. The major proteins of HDL, apoA-I and apoA-II, as well as other proteins such as paraoxonase that cotransport with HDL in plasma, are well-known to have antioxidant properties. As a consequence, HDL has the capacity to inhibit the oxidative modification of low-density lipoprotein (LDL) in a process that reduces the atherogenicity of these lipoproteins. HDL also possesses other antiinflammatory properties. By virtue of their ability to inhibit the expression of adhesion molecules in endothelial cells, they reduce the recruitment of blood monocytes into the artery wall. These antioxidant and antiinflammatory properties of HDL may be as important as its cholesterol efflux function in terms of protecting against the development of atherosclerosis. Key Words: antiinflammatory Ⅲ antioxidant Ⅲ atherosclerosis Ⅲ high-density lipoprotein I n epidemiological studies, high plasma levels of highdensity lipoproteins (HDLs) protect against the development of atherosclerosis. 1,2 The precise mechanism is uncertain, although most likely it is the consequence of one or more of the reported actions of HDL. 3 The best known of these relates to the ability of HDL to promote the efflux of cholesterol from cells in the artery wall. 4 However, HDLs have additional functions, some of which may be unrelated to their role in plasma lipid transport. For example, they bind lipopolysaccharide, 5 stimulate endothelial cell movement, 6 inhibit the synthesis of plateletactivating factor by endothelial cells, 7 and protect erythrocytes against the generation of procoagulant activity. 8 HDLs stimulate prostacyclin synthesis by endothelial cells. 9 They also bind prostacyclin and thus prolong its half-life. 10 They reduce epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells. 11 HDLs are antithrombotic. 12 They modulate endothelial function, 13 probably by stimulating endothelial nitric oxide (NO) production. 14 HDLs also possess antioxidant and antiinflammatory activities. 3,[15][16][17][18][19][20][21] The degree to which any or all of these nonlipid transport functions of HDL contribute to a protection against atherosclerosis is still uncertain, although evidence is mounting that at least some of them may be especially important.This review focuses on the antioxidant and antiinflammatory properties of HDL (Figure 1). It summarizes the role of oxidation and inflammation in atherogenesis and describes how these processes may be inhibited by HDL. It concludes with an assessment of the potential clinical importance of the antioxidant and antiinflammatory propert...

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HDL and apolipoprotein A-I protect erythrocytes against the generation of procoagulant activity.

Cited by 80 publications

References 30 publications

Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

High-Density Lipoproteins in Stroke

Anti-Inflammatory Properties of HDL

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