HDL

Kon, Valentina; Linton, MacRae F.

doi:10.1681/asn.2015070793

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…HDL is an atheroprotective cholesterol and a marker for atherosclerosis and a predictor of cardiovascular events. 13 It was lower in the severe group, indicating that coronary-related cardiovascular events may aggravate the progression of COVID-19. In this study, the rate of CAD was significantly higher in the severe group than in the non-severe group, which may also be related to HDL.…”

Section: Discussionmentioning

confidence: 91%

Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19)

Xie

You

et al. 2020

Circ J

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Background:To investigate the effect of cardiovascular disease (CVD) on the global pandemic, coronavirus disease 2019 (COVID-19), we analyzed the cases of laboratory-confirmed COVID-19 patients in Wuhan.Methods and Results: Data were extracted from the medical records. SARS-CoV-2 RNA was confirmed by RT-PCR. A total of 33 (53.2%) of 62 cases with CVD, who had higher prevalence of severe COVID-19 compared with non-CVD patients (P=0.027). The median age of all patients was 66.0 (53.3, 73.0) years old. Coronary artery disease (11.3%) and hypertension (38.7%) were the common coexisting CVDs in COVID-19 patients. High-sensitivity cardiac troponin I (hs-cTnI), creatinine, high-density lipoproteincholesterol, interleukin-6, C-reactive protein, prothrombin time, and D-dimer levels in the severe COVID-19 with CVD group were higher than in the non-severe COVID-19 with CVD group (P<0.05). For all patients, chest computed tomography (CT) showed ground-glass opacity (66.1%), local (21.0%), bilateral (77.4%), and interstitial abnormalities (4.8%). In COVID-19 patients with CVD, 27 (81.8%) were cured and discharged. 6 (18.2%) remained in hospital, including 2 (3.2%) patients requiring intubation and mechanical ventilation. The hs-cTnI levels in the remaining hospitalized patients were higher than in the discharged patients (P=0.047). Conclusions:CVDs play a vital role in the disease severity of COVID-19. COVID-19 could result in myocardial injury, which affects the prognosis of COVID-19.

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Section: Discussionmentioning

confidence: 91%

Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19)

Xie

You

et al. 2020

Circ J

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“…Currently, no consensus has been reached with respect to standardization of these parameters, so that such assays are not fully comparable to, for example, values obtained by clinical chemistry determinations. In our work, we used an established assay that is using human macrophage foam cells, in which all efflux pathways are active (ABCA1, 47% contribution, determined by addition of probucol; SR-BI, 19% contribution, determined by addition of BLT-1; and ABCG1, 30% contribution, determined by the addition of probucol and BLT-1 [U.J.F.T., unpublished observations]); this offers certain advantages over, for example, murine J774 macrophages equilibrated with cholesterol label, in which efflux mainly depends on the ABCA1 system (40). HDL isolation was carried out with a protocol widely used in efflux studies (15,21,23,24).…”

Section: Discussionmentioning

confidence: 99%

HDL Cholesterol Efflux Predicts Incident New-Onset Diabetes After Transplantation (NODAT) in Renal Transplant Recipients Independent of HDL Cholesterol Levels

et al. 2019

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In renal transplant recipients (RTRs), new-onset diabetes after transplantation (NODAT) is a frequent and serious complication limiting survival of graft and patient. However, the underlying pathophysiology remains incompletely understood. In vitro and in preclinical models, HDL can preserve β-cell function, largely by mediating cholesterol efflux, but this concept has not been evaluated in humans. This study investigated whether baseline cholesterol efflux capacity (CEC) in RTRs is associated with incident NODAT during follow-up. This prospective longitudinal study included 405 diabetes-free RTRs with a functioning graft for >1 year. During a median (interquartile range) follow-up of 9.6 (6.6–10.2) years, 57 patients (14.1%) developed NODAT. HDL CEC was quantified using incubation of human macrophage foam cells with apolipoprotein B–depleted plasma. Baseline CEC was significantly lower in patients developing NODAT during follow-up (median 6.84% [interquartile range 5.84–7.50%]) compared with the NODAT-free group (7.44% [6.46–8.60%]; P = 0.001). Kaplan-Meier analysis showed a lower risk for incident NODAT with increasing sex-stratified tertiles of HDL efflux capacity (P = 0.004). Linear regression analysis indicated that CEC is independently associated with incident NODAT (P = 0.04). In Cox regression analyses, CEC was significantly associated with NODAT (hazard ratio 0.53 [95% CI 0.38–0.76]; P < 0.001), independent of HDL cholesterol levels (P = 0.015), adiposity (P = 0.018), immunosuppressive medication (P = 0.001), and kidney function (P = 0.01). Addition of CEC significantly improved the predictive power of the Framingham Diabetes Risk Score (P = 0.004). This study establishes HDL CEC as a strong predictor of NODAT in RTRs, independent of several other recognized risk factors.

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Sex‐related associations of high‐density lipoprotein cholesterol with aortic stiffness and endothelial glycocalyx integrity in treated hypertensive patients

Triantafyllidi

Benas

Schoinas

et al. 2020

J of Clinical Hypertension

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Arterial hypertension affects more than ¼ of the population worldwide representing one of the most important risk factors for cardiovascular disease (CVD). The complications of hypertension disease vary from subclinical organ damage (hypertension mediated organ damage, HMOD) to coronary artery disease, stroke, heart failure, and chronic kidney disease, major causes of morbidity and mortality. 1 HOMD (left ventricular hypertrophy, reduced coronary flow reserve, increased carotid intima-media thickness, microalbuminuria,

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HDL

Cited by 3 publications

References 17 publications

Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19)

Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19)

HDL Cholesterol Efflux Predicts Incident New-Onset Diabetes After Transplantation (NODAT) in Renal Transplant Recipients Independent of HDL Cholesterol Levels

Sex‐related associations of high‐density lipoprotein cholesterol with aortic stiffness and endothelial glycocalyx integrity in treated hypertensive patients

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