HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Zhan, Yunyan; Wang, Haisheng; Zhang, Lu; Pei, Fei; Chen, Zhi

doi:10.3389/fcell.2020.605609

Cited by 7 publications

(3 citation statements)

References 51 publications

(66 reference statements)

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“…As described previously, HDAC6 can also function as a ubiquitin-binding protein to participate in aggresome formation ( 22 ). Additionally, HDAC6 can also mediate the acetylation of cortactin and microtubules to regulate autophagy via autophagosome-lysosome fusion and autophagosome transportation ( 23 , 86 , 156 ). Furthermore, HDAC6 interacts with p62 to regulate autophagy via various mechanisms ( 23 , 91 , 104 , 107 ).…”

Section: Discussionmentioning

confidence: 99%

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

Chang

et al. 2021

Front. Immunol.

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Autophagy fights against harmful stimuli and degrades cytosolic macromolecules, organelles, and intracellular pathogens. Autophagy dysfunction is associated with many diseases, including infectious and inflammatory diseases. Recent studies have identified the critical role of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasomes activation in the innate immune system, which mediates the secretion of proinflammatory cytokines IL-1β/IL-18 and cleaves Gasdermin D to induce pyroptosis in response to pathogenic and sterile stimuli. Accumulating evidence has highlighted the crosstalk between autophagy and NLRP3 inflammasome in multifaceted ways to influence host defense and inflammation. However, the underlying mechanisms require further clarification. Histone deacetylase 6 (HDAC6) is a class IIb deacetylase among the 18 mammalian HDACs, which mainly localizes in the cytoplasm. It is involved in two functional deacetylase domains and a ubiquitin-binding zinc finger domain (ZnF-BUZ). Due to its unique structure, HDAC6 regulates various physiological processes, including autophagy and NLRP3 inflammasome, and may play a role in the crosstalk between them. In this review, we provide insight into the mechanisms by which HDAC6 regulates autophagy and NLRP3 inflammasome and we explored the possibility and challenges of HDAC6 in the crosstalk between autophagy and NLRP3 inflammasome. Finally, we discuss HDAC6 inhibitors as a potential therapeutic approach targeting either autophagy or NLRP3 inflammasome as an anti-inflammatory strategy, although further clarification is required regarding their crosstalk.

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Section: Discussionmentioning

confidence: 99%

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

Chang

et al. 2021

Front. Immunol.

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“…Among all HDAC enzymes, HDAC6 is increasingly emerging as a pivotal player in autophagy since it has been associated with the modulation of different pathways related to this biological process ( Figure 1 ) [ 76 ]. HDAC6 works in cooperation with the ubiquitin–proteasome system (UPS), favoring the processing of misfolded proteins [ 77 ].…”

Section: Role Of Hdac6 In Autophagic Processesmentioning

confidence: 99%

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights

Passaro

Papulino

Chianese

et al. 2021

Cancers

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Autophagy is an essential intracellular catabolic mechanism involved in the degradation and recycling of damaged organelles regulating cellular homeostasis and energy metabolism. Its activation enhances cellular tolerance to various stresses and is known to be involved in drug resistance. In cancer, autophagy has a dual role in either promoting or blocking tumorigenesis, and recent studies indicate that epigenetic regulation is involved in its mechanism of action in this context. Specifically, the ubiquitin-binding histone deacetylase (HDAC) enzyme HDAC6 is known to be an important player in modulating autophagy. Epigenetic modulators, such as HDAC inhibitors, mediate this process in different ways and are already undergoing clinical trials. In this review, we describe current knowledge on the role of epigenetic modifications, particularly HDAC-mediated modifications, in controlling autophagy in cancer. We focus on the controversy surrounding their ability to promote or block tumor progression and explore the impact of HDAC6 inhibitors on autophagy modulation in cancer. In light of the fact that targeted drug therapy for cancer patients is attracting ever increasing interest within the research community and in society at large, we discuss the possibility of using HDAC6 inhibitors as adjuvants and/or in combination with conventional treatments to overcome autophagy-related mechanisms of resistance.

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“…HDAC6 regulates the fusion of autophagosomes and lysosome during odontoblast differentiation. Decreased autophagy results in downregulation of odontoblastic differentiation capacity (75).…”

Section: Epigeneticsmentioning

confidence: 99%

Wnt Signalling in Regenerative Dentistry

Birjandi¹,

Sharpe²

2021

Front. Dent. Med

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Teeth are complex structures where a soft dental pulp tissue is enriched with nerves, vasculature and connective tissue and encased by the cushioning effect of dentin and the protection of a hard enamel in the crown and cementum in the root. Injuries such as trauma or caries can jeopardise these layers of protection and result in pulp exposure, inflammation and infection. Provision of most suitable materials for tooth repair upon injury has been the motivation of dentistry for many decades. Wnt signalling, an evolutionarily conserved pathway, plays key roles during pre- and post-natal development of many organs including the tooth. Mutations in the components of this pathway gives rise to various types of developmental tooth anomalies. Wnt signalling is also fundamental in the response of odontoblasts to injury and repair processes. The complexity of tooth structure has resulted in diverse studies looking at specific compartments or cell types of this organ. This review looks at the current advances in the field of tooth development and regeneration. The objective of the present review is to provide an updated vision on dental biomaterials research, focusing on their biological properties and interactions to act as evidence for their potential use in vital pulp treatment procedures. We discuss the outstanding questions and future directions to make this knowledge more translatable to the clinics.

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HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Cited by 7 publications

References 51 publications

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights

Wnt Signalling in Regenerative Dentistry

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