HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
Tuo Zhang,
Yuntong Tong,
Rengguang Zhu
et al.
Abstract:Rationale:
Primordial follicles are limited in number and cannot be regenerated, dormant primordial follicles cannot be reversed once they enter a growth state. Therefore, the length of the female reproductive lifespan depends on the orderly progression and selective activation of primordial follicles, the mechanism of which remains unclear.
Methods:
We used human ovarian cortical biopsy specimens, granulosa cells from diminished ovarian reserve (DOR) patients,
Hd… Show more
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