HCV-RNA quantification in liver bioptic samples and extrahepatic compartments, using the abbott Real Time HCV assay

Antonucci, F.P.; Cento, Valeria; Sorbo, M.C.; Manuelli, M.; Lenci, Ilaria; Sforza, D.; Carlo, Domenico Di; Mihalj, Martina; Manzia, Tommaso Maria; Angélico, M.; Tisone, Giuseppe; Perno, Carlo Federico; Ceccherini‐Silberstein, Francesca

doi:10.1016/j.jviromet.2017.04.001

Cited by 3 publications

(2 citation statements)

References 16 publications

(20 reference statements)

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“…Despite the well-known tropism of each virus, HIV and HCV RNA have been found in other tissue compartments. HCV RNA has been detected in peripheral blood mononuclear cells (non-T cells), lymph nodes, ascites fluid, CSF, and brain matter (Table 1) (Antonucci et al 2017; Morgello 2005; Weissenborn et al 2009). HIV has been described in brain matter, lymph nodes, reproductive organs, lungs, and spleen (Costiniuk and Jenabian 2015).…”

Section: Similarities and Differences In Virally Mediated Hiv And Hcvmentioning

confidence: 99%

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

et al. 2018

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HIV and hepatitis C virus (HCV) have both been associated with cognitive impairment. Combination antiretroviral therapy (cART) has dramatically changed the nature of cognitive impairment in HIV-infected persons, while the role of direct-acting antivirals (DAA) in neurocognition of HCV-infected individuals remains unclear. Also, whether HIV and HCV interact to promote neurocognitive decline or whether they each contribute an individual effect continues to be an open question. In this work, we review the virally mediated mechanisms of HIV- and HCV-mediated neuropathogenesis, with an emphasis on the role of dual infection, and discuss observed changes with HIV viral suppression and HCV functional cure on neurocognitive impairments.

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Section: Similarities and Differences In Virally Mediated Hiv And Hcvmentioning

confidence: 99%

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

et al. 2018

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“…El VHC se transmite principalmente por contacto con sangre por vía parenteral y menos frecuentemente por vía sexual y por transmisión vertical. Existe plausibilidad biológica de que el VHC se transmita también por otros fluidos corporales de los que se ha aislado con variable frecuencia, tales como líquido ascítico (Antonucci et al, 2017;Liou et al, 1992), bilis (Haruna, Kanda, Honda, Takao, & Hayashi, 2001), líquido peritoneal (Cusumano, Poratto, del Pino, Fernández, & Vilches, 2005;González et al, 2010), líquido cefalorraquídeo (Laskus et al, 2002), saliva (Caldeira et al, 2013;Xavier, de Deus, de Almeria, Duarte, & de Castro, 2015), semen (Bradshaw et al, 2015, Turner et al, 2016, secreciones vaginales (Nowicki et al, 2005;Wang et al, 2011), orina (Shafique et al, 2009), secreciones rectales (Foster et al, 2017), heces (Heidrich et al, 2016), sudor (Ortiz-Movilla et al, 2002, humor acuoso y lágrimas (Atas et al, 2016), secreciones nasales (Aaron et al, 2008;McMahon et al, 2004), líquido amniótico (Delamare et al, 1999) y líquido folicular (Devaux et al, 2003). Es de hacer notar que no todos los estudios que han aislado VHC de estos fluidos han demostrado la infectividad de las partículas aisladas, y que en el caso de la leche materna, Pfaender y colaboradores (2013) llegaron a la conclusión que la actividad antiviral de la leche materna hace que el riesgo de transmisión por lactancia materna sea muy bajo, a menos que se realice con los pezones sangrantes.…”

Section: Transmisión Y Factores De Riesgounclassified

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C

Vélez‐Möller

2017

CTS

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La hepatitis C, infección producida por el virus de la hepatitis C (VHC), que se transmite por sangre, es la principal causa de hepatitis crónica, cirrosis y cáncer del hígado a nivel mundial. La mortalidad, incidencia y prevalencia de las infecciones por VHC han ido en aumento, superando en muchos casos la de otras infecciones como el VIH. Más de 71 millones de personas en el mundo padecen hepatitis C crónica, pero el 80% desconoce que tiene la infección y solamente 1% ha recibido tratamiento, pese a que existen medicamentos que curan la infección en más del 90% de los casos y pueden disminuir el riesgo de las complicaciones que llevan a la muerte. En el 2016 los países miembros de la Organización Mundial de la Salud (OMS) acordaron la primera estrategia mundial del sector salud contra la hepatitis víricas 2016-2021, y para su implementación es necesario concienciar a todos los involucrados acerca de la magnitud de las hepatitis virales. Esta revisión aborda aspectos epidemiológicos, microbiológicos y clínicos con el propósito de presentar un panorama general de la situación actual de la hepatitis C a nivel mundial y nacional.

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Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series

Franco,

Gosalvez,

Gimeno

et al. 2023

Transpl Int

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The transmission of hepatitis C virus from viremic donors to seronegative recipients of kidney transplantation is well documented. Pre-transplant administration of direct-acting antivirals prevents viremia, but the seroconversion rate is high. We studied the transmission of the virus through the transplanted tissue by determining viral RNA in 15 kidneys from 8 deceased viremic donors, 5 males and 3 females aged 52.3 ± 15 years. HIV positive donors and active intravenous drugs abusers were discarded to avoid possible window periods in the virus transmission. Recipients, 9 males and 6 females aged 52.7 ± 18 years, were treated with glecaprevir/pibrentasvir for 8 weeks and received immunosuppression with thymoglobulin, tacrolimus, sirolimus and prednisone. Hepatitis C Virus was detected in 9 of the 15 histological samples analyzed but viremia was detected in no recipient at day 1 and 7 post–transplantation and 12 weeks after the treatment. However, 13 of the 15 recipients had seroconverted within 1 month. In conclusion, Hepatitis C virus was detected in a significant proportion of tissue of kidney grafts from viremic donors, but treatment with direct-acting antivirals avoids the transmission of the virus from donor to recipient. Then Donor pools should be expanded.

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HCV-RNA quantification in liver bioptic samples and extrahepatic compartments, using the abbott Real Time HCV assay

Cited by 3 publications

References 16 publications

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C

Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series

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HCV-RNA quantification in liver bioptic samples and extrahepatic compartments, using the abbott Real Time HCV assay

Cited by 3 publications

References 16 publications

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns

Estado actual de la epidemiologí­a, diagnóstico, tratamiento y control de la hepatitis C

Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series

Contact Info

Product

Resources

About

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C