HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer

Attallah, Abdelfattah M.; El‐Far, Mohamed; Abdelrazek, Mohamed A; Omran, Mohamed M.; Mahmoud, Ashraf Z.; Khalifa, Hager S.; Ahmed, Mohamed M.; El-Dosoky, Ibrahim

doi:10.1007/s12282-017-0829-1

Cited by 6 publications

(17 citation statements)

References 25 publications

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“…Although HCV infection was previously correlated with poor prognostic markers in Egyptian breast cancer patients, 33 the present study directly provides survival data for the first time in breast cancer patients with HCV seropositivity.…”

Section: Discussionmentioning

confidence: 85%

High Seroprevalence of Hepatitis C Virus Antibody in Breast Cancer Patients in Egypt

Hussein

El‐Ghitany

Omran

et al. 2021

Breast Cancer�(Auckl)

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Background: Hepatitis C virus (HCV) is a known risk factor for hepatocellular carcinoma. Several epidemiological studies have pointed out to an association of HCV infection with other extrahepatic malignancies. The role of chronic HCV in breast cancer causation is less clear. Egypt is an endemic area of HCV infection with resulting significant morbidity. The association between HCV status and breast cancer risk in Egyptian women is hitherto unknown. Methods: A retrospective study was performed. The prevalence of anti-HCV seropositivity was estimated in a sample of women with a breast cancer diagnosis, retrieved from the hospital records, and was compared to the raw data of a population study in Egypt. Anti-HCV negative and positive patients were compared regarding the disease course and outcome. Results: Retrospective analysis revealed a markedly high prevalence of anti-HCV seropositivity in young breast cancer patients. In patients younger than 45 years, 13.4% were anti-HCV positive. Seropositivity was 6-fold higher in these patients than in adult females of the same age without cancer diagnosis ( P = .003). The biological type, tumor size, nodal status, and disease-free survival were not affected by the patients’ HCV status. Conclusion: Young Egyptian breast cancer patients have a dramatically high prevalence of HCV seropositivity. Further population studies are strongly required to investigate the epidemiological association of these two significant health problems.

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Section: Discussionmentioning

confidence: 85%

High Seroprevalence of Hepatitis C Virus Antibody in Breast Cancer Patients in Egypt

Hussein

El‐Ghitany

Omran

et al. 2021

Breast Cancer�(Auckl)

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Section: Discussionmentioning

confidence: 89%

“…23.7%), our team found that HCV-NS4 was increased in BC HCV-infected patients compared to HCVinfected patients with benign diseases [9]. Elevated viral protein levels were related to tumor severity including in ltrated lymph nodes high grades, late stages and large size [9]. Here, we investigated the association between the impact of HCV infection on BC progression and mutant p53 and c-Myc oncoproteins expression.…”

Section: Discussionmentioning

confidence: 91%

“…Regarding disease progression, oncoproteins of HCV may involve in promoting some gene expression that, in turn, has been attributed to tumorigenesis [9]. In our previous study, we found that elevated HCV-NS4 in serum of BC patients were associated with BC severity features like in ltrated lymph nodes, high grades, advanced stages and large tumor size [9]. The p53 is the tumor suppressor gene that signi cantly correlated with several human cancers [10].…”

Section: Introductionmentioning

confidence: 98%

“…HCV-untreated patients had the highest 9-year BC cumulative incidence [8]. Regarding disease progression, oncoproteins of HCV may involve in promoting some gene expression that, in turn, has been attributed to tumorigenesis [9]. In our previous study, we found that elevated HCV-NS4 in serum of BC patients were associated with BC severity features like in ltrated lymph nodes, high grades, advanced stages and large tumor size [9].…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus may accelerate breast cancer progression by increasing mutant p53 and c-Myc oncoproteins circulating levels

Fathy

Abdelrazek

Attallah

et al. 2023

Preprint

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Background: Hepatitis C virus (HCV) was reported to relate to polymorphous and frequent extrahepatic manifestation. Despite the limited studies, HCV viral oncoproteins may be implicated in breast cancer (BC) tumor aggressiveness. In a trial to elucidate a mechanistic link, this study aimed to investigate a mutant p53 and c-Myc oncoproteins expression levels in BC patients with and without HCV infection. Methods: A total of 215 BC patients (119 infected and 96 non-infected with HCV) were collected. ELISA was used for detection of anti-HCV antibodies, mutant p53, c-Myc, HCV-NS4, CEA, CA 125 and CA-15.3. Results: HCV infection was related to BC late stages, lymph node invasion, distant metastasis, high grades and large size. HCV infected patients had a significantly (P<0.05) higher WBCs, ALT and AST activity, bilirubin CEA, CA125 and CA15.3 levels, and reduced haemoglobin, albumin and RBCs count. Regardless of tumor severity, HCV infection was associated with significant elevated levels of mutant p53 (22.5±3.5 µg/mL; 1.9-fold increase) and c-Myc (21.4±1.8 µg/mL; 1.5-fold increase). Among HCV-infected patients, elevated levels of p53 and c-Myc were significantly correlated with elevated tumor markers (CEA, CA 125 and CA15.3) and HCV-NS4 levels. Conclusions: this study concluded that HCV infection may be accompanied with BC severity behaviour and this may be owing to elevated expression of mutant p53 and c-Myc oncoproteins.

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Hepatitis C virus may accelerate breast cancer progression by increasing mutant p53 and c-Myc oncoproteins circulating levels

Fathy,

Abdelrazek,

Attallah

et al. 2023

Breast Cancer

Self Cite

View full text Add to dashboard Cite

Background Hepatitis C virus (HCV) was reported to relate to polymorphous and frequent extrahepatic manifestation. Despite the limited studies, HCV viral oncoproteins may be implicated in breast cancer (BC) tumor aggressiveness. In a trial to elucidate a mechanistic link, this study aimed to investigate a mutant p53 and c-Myc oncoprotein expression levels in BC patients with and without HCV infection. Methods A total of 215 BC patients (119 infected and 96 non-infected with HCV) were collected. ELISA was used for detection of anti-HCV antibodies, mutant p53, c-Myc, HCV-NS4, CEA, CA 125, and CA-15.3. Results HCV infection was related to BC late stages, lymph-node invasion, distant metastasis, high grades, and large size. HCV-infected patients had a significantly (P < 0.05) higher WBCs, ALT and AST activity, bilirubin CEA, CA125 and CA15.3 levels, and reduced hemoglobin, albumin, and RBCs count. Regardless of tumor severity, HCV infection was associated with significant elevated levels of mutant p53 (22.5 ± 3.5 µg/mL; 1.9-fold increase) and c-Myc (21.4 ± 1.8 µg/mL; 1.5-fold increase). Among HCV-infected patients, elevated levels of p53 and c-Myc were significantly correlated with elevated tumor markers (CEA, CA 125, and CA15.3) and HCV-NS4 levels. Conclusions This study concluded that HCV infection may be accompanied with BC severity behavior and this may be owing to elevated expression of mutant p53 and c-Myc oncoproteins.

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HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer

Abstract: HCV-NS4 appears to be associated with BC progression features. Oncologists treating such BC patients should consider HCV screening to enable the early identification and to prevent progression of the disease.

Cited by 6 publications

References 25 publications

High Seroprevalence of Hepatitis C Virus Antibody in Breast Cancer Patients in Egypt

High Seroprevalence of Hepatitis C Virus Antibody in Breast Cancer Patients in Egypt

Hepatitis C virus may accelerate breast cancer progression by increasing mutant p53 and c-Myc oncoproteins circulating levels

Hepatitis C virus may accelerate breast cancer progression by increasing mutant p53 and c-Myc oncoproteins circulating levels

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