HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study

Laar, T.J.W. van de; Hollander, J.; Boerekamps, Anne; Newsum, Astrid M.; Schinkel, Janke; Prins, Maria; Coul, Eline Op de; Valk, Marc van der; Geerlings, Suzanne E.; Goorhuis, Abraham; Hovius, Joppe W.; Lempkes, B.; Nellen, F.J.B.; Poll, T. van der; Prins, Jan M.; Vugt, Michèle van; Wiersinga, W. Joost; Wit, Ferdinand W; Duinen, Marlies van; Eden, J. van; Hazenberg, A.; Hes, A.M.H. van; Pijnappel, F.J.J.; Smalhout, S.Y.; Weijsenfeld, A.M.; Jurriaans, Suzanne; Back, Nicole K. T.; Zaaijer, Hans L.; Berkhout, B.; Cornelissen, Marion; Schinkel, Christian; Wolthers, Katja C.; Peters, Erica J.; Agtmael, Michiel A. van; Autar, Reshma; Bomers, Marije K.; Sigaloff, K.C.E.; Heitmuller, M.; Laan, Liedewij; Ang, C. Wim; Houdt, Robin van; Jonges, Marcel; Berge, M. van den; Stegeman, Arjan; Baas, S.; Looff, L. Hage de; Reuwer, Anne Q; Veenemans, Jacobien; Wintermans, Bas; Pronk, M. J. H.; Ammerlaan, Heidi S. M.; Bersselaar, D.N.J. van den; Munnik, E. S. de; Deiman, Birgit; Jansz, Arjen R.; Scharnhorst, Volkher; Tjhie, Jeroen H. T.; Wegdam, M.C.A.; Eeden, Arne van; Nellen, Jeannine; Brokking, Wilma; Elsenburg, L.; Nobel, H.; Kasteren, M.E.E. van; Berrevoets, Marvin A.H.; Brouwer, Annemarie E.; Adams, Andrew L.; Erve, R. van; Wiel, B.A.F.M. de Kruijf-van de; Keelan-Phaf, S.; Ven, B. van de; Buiting, A. G. M.; Murck, J.L.; Vries-Sluijs, Theodora E. M. S. de; Bax, Hannelore I.; Gorp, Eric C. M. Van; Jong-Peltenburg, N.C. de; Melo, Martim; Nood, Els van; Nouwen, Jan L.; Rijnders, Bart; Rokx, Casper; Schurink, Carolina A. M.; Slobbe, Lennert; Verbon, Annelies; Bassant, N.; Beek, J.E.A. van; Vriesde, M.; Zonneveld, L. M. van; Groot, J. de; Boucher, Charles A.; Koopmans, Marion; Kampen, Jeroen J.A. van; Branger, Judith; Douma, Reuben; Cents-Bosma, A.S.; Ven, C.J.H.M. Duijf-van de; Schippers, Emile F.; Nieuwkoop, Cees van; IJperen, J.M. van; Geilings, J.; Burgel, N.D. van; Leyten, Eliane M. S.; Hut, G. van der; Gelinck, L. B. S.; Mollema, Femke; Davids-Veldhuis, S.; Tearno, C.; Wildenbeest, G.S.; Heikens, E.; Groeneveld, P. H. P.; Bouwhuis, J.W.; Lammers, A.J.J.; Kraan, S.; Hulzen, Astrid G W van; Kruiper, M.S.M.; Bliek, G.L. van der; Bor, Petra; Debast, Sylvia B.; Wagenvoort, G.H.J.; Kroon, F.P.; Boer, M.G.J. de; Jolink, H.; Lambregts, Merel M C; Roukens, Anna H E; Scheper, Henk; Dorama, W.; Holten, N. van; Claas, Eric C. J.; Wessels, Els; Hollander, Jan G. den; Brouwer, C.J.; Smit, Jesper; Struik-Kalkman, D.; Niekerk, T.G.C.M. van; Moussaoui, R. El; Pogány, K.; Pontesilli, O.; Lowe, Selwyn H.; Lashof, Astrid M. L. Oude; Posthouwer, D.; Wolfswinkel, Marlies E van; Ackens, Robin; Burgers, Kristina; Schippers, J. A.; Weijenberg-Maes, B.; Loo, Inge H. M. van; Havenith, Thomas; Vonderen, Marit G. A. van; Kampschreur, Linda M.; Faber, S. M.; Steeman-Bouma, R.; Moujahid, A. Al; Kootstra, G. J.; Delsing, Corine E.; Plas, Matthijs; Scheiberlich, L.; Kortmann, W.; Twillert, Gitte van; Renckens, R.; Ruiter-Pronk, D.; Truijen-Oud, F.A. van; Stuart, J. W. T. Cohen; Jansen, Evertjan; Hoogewerf, Marieke; Rozemeijer, Wouter; Reijden, W.A. van der; Sinnige, Jan C.; Brinkman, Kees; Berk, Guido E.L. van den; Blok, W; Lettinga, Kamilla D.; Regt, Marina de; Schouten, W. E. M.; Stalenhoef, Janneke E.; Veenstra, J.; Vrouenraets, S. M. E.; Blaauw, H.; Geerders, G.F.; Kleene, M.J.; Kok, Marc R.; Knapen, Marjo H. J.; Meché, I.B. van der; Mulder-Seeleman, E.; Toonen, A.J.M.; Wijnands, S.; Wttewaal, E.; Kwa, David; Crevel, Reinout van; Dofferhoff, Anton S M; Hofstede, H.J.M. ter; Hoogerwerf, Jacobien J.; Keuter, Monique; Richel, Olivier; Albers, M.; Grintjes-Huisman, Karin J. T.; Haan, M. de; Marneef, M.; Strik-Albers, R.; Rahamat‐Langendoen, Janette; Stelma, F.F.; Burger, David M.; Gisolf, Elisabeth H.; Hassing, Robert Jan; Claassen, Mark A. A.; Beest, G. ter; Bentum, P.H.M. van; Langebeek, Nienke; Tiemessen, R.; Swanink, C.M.A.; Lelyveld, S.F.L. van; Soetekouw, Robert; Prijt, L.M.M. van der; Swaluw, J. van der; Bermon, N.; Jansen, Ronald; Herpers, Bjorn L.; Veenendaal, Dick; Verhagen, Dominique W M; Lauw, Fanny N.; Broekhuizen, Michelle; Wijk, Michiel P. van; Bierman, Wouter F W; Bakker, Margreet; Kleinnijenhuis, Johanneke; Kloeze, E.; Middel, Ananja; Postma, Douwe F.; Stienstra, Ymkje; Wouthuyzen-Bakker, Marjan; Boonstra, André; Jonge, H. de; Meulen, P. A. van der; Weerd, D.A. de; Niesters, H. G. M.; Leer-Buter, Coretta van; Knoester, Marjolein; Hoepelman, A. I. M.; Arends, Joop E.; Barth, Roos E.; Bruns, Anke H. W.; Ellerbroek, Pauline M.; Mudrikova, Tania; Oosterheert, Jan Jelrik; Schadd, E.M.; Welzen, Berend J van; Aarsman, K.; Santen, B.M.G. Griffioen-van; Kroon, I. de; Berkel, M. van; Rooijen, C.S.A.M. van; Schuurman, Rob; Verduyn-Lunel, F.; Wensing, Annemarie M. J.; Reiss, Peter; Zaheri, S.; Boyd, Anders; Bezemer, Daniela; Sighem, A.I. van; Smit, Colette; Hillebregt, Mariska; Jong, A. de; Woudstra, T.J.; Bergsma, Derek; Meijering, Roelien A. M.; Sande, L. van de; Rutkens, T.; Vliet, Stefan van der; Groot, Lcpgm de; Akker, Marjan van den; Bakker, Y.; Berkaoui, A. El; Bezemer, M.; Brétin, N.; Djoechro, E.; Groters, M.; Kruijne, E.; Lelivelt, K.J.; Lodewijk, C.; Lucas, Eric; Munjishvili, L.; Paling, F.; Peeck, B.; Ree, Cornelis L. P. van de; Regtop, R.; Ruijs, Y.; Schoorl, Maartje; Schnörr, P.; Scheigrond, A.; Tuijn, E.; Veenenberg, L.; Visser, Kirsten; Witte, E.C.

doi:10.1016/s2352-3018(20)30301-5

Cited by 50 publications

(42 citation statements)

References 29 publications

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“…Together with our collaborators, we were able to identify 309 patients within the Viennese MSM population who had evidence for HCV exposure by anti-HCV seropositivity or ever positive HCV-RNA viremia. Based on solid estimators, the HCV seropositivity rate in the Viennese MSM population may be as high as 30%, which is in line with reports from other European centers reporting high numbers of HCV infections in MSM [ 4 , 5 ]. Relying on the collaboration with PCPs and gay health specialists and our established hepatitis hotline (HCV-phone), we invited HCV-seropositive patients to an appointment comprising TE and laboratory testing, including HCV-RNA-PCR.…”

Section: Discussionsupporting

confidence: 83%

“…Recently, the proportion of MSM accounted for about 30–40% of patients presenting with untreated HCV infection at our human immunodeficiency virus (HIV)/hepatitis outpatient clinic at the Vienna General Hospital (VGH). This is in line with reports from other European centers describing a high incidence/prevalence of HCV infection [ 3 ], even in times of unrestricted access to direct-acting antiviral (DAA) treatment [ 4 ], not only in HIV-positive MSM but also in HIV-negative MSM, especially if they take pre-exposure prophylaxis (PrEP) [ 5 , 6 ]. Unprotected anal intercourse and nasal and/or intravenous drug use are considered major modes of transmission for HCV in MSM, and respective risk behavior is commonly observed in the Viennese MSM population [ 7 ].…”

Section: Introductionsupporting

confidence: 85%

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Outcomes of an HCV elimination program targeting the Viennese MSM population

Jachs

Binter

Chromy

et al. 2021

Wien Klin Wochenschr

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Summary Background and aims Recent reports suggest an increasing incidence of hepatitis C virus (HCV) infections among MSM (men-who-have-sex-with-men). Early treatment with direct-acting antivirals (DAAs) achieves high cure rates and prevents further HCV transmission. We offered barrier-free HCV screening in the Viennese MSM population and immediate access to DAA treatment. Methods In collaboration with gay health specialists, we screened for HCV seropositivity in Viennese MSM between 2019 and 2020. Barrier-free HCV-RNA-PCR tests, transient elastography (TE) and immediate access to DAA treatment were offered. Results A total of 310 HCV-seropositive patients were identified. Of those, 145 could be contacted and 109 attended their appointment at our clinic. HIV-coinfection was highly prevalent in our cohort (n = 86/145; 78.9%), while pre-exposure prophylaxis (PrEP) was taken by 21.7% (n = 5/23) of non-HIV patients. Sexual risk behavior and (history of) intravenous drug use was reported by 32.1% and 13.8% of patients, respectively. Most MSM had already achieved sustained virological response (SVR) to previous antiviral treatment (n = 72, 66.1%) or experienced spontaneous clearance (n = 10, 9.2%). Advanced fibrosis was only detected in 3/109 (2.8%) patients. 30 MSM tested positive for HCV-RNA and DAA treatment was initiated in 29 patients – all achieved SVR. Conclusion A targeted HCV test-and-treat program revealed a high prevalence of HCV seropositivity among Viennese MSM, potentially associated with high-risk sexual behavior and drug use. Early DAA treatment seems warranted in viremic HCV-MSM as SVR was 100%, which in turn prevents further HCV transmission.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionsupporting

confidence: 85%

Outcomes of an HCV elimination program targeting the Viennese MSM population

Jachs

Binter

Chromy

et al. 2021

Wien Klin Wochenschr

View full text Add to dashboard Cite

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“…Second, patients experience improvement in HRQOL [ 18 , 19 ]. Furthermore, individual viral eradication leads to a reduction of the general burden of HCV infection and reduces further viral spreading [ 20 , 21 ]. Despite its positive effects, implementation of antiviral treatment in the PWID population remains insufficient.…”

Section: Discussionmentioning

confidence: 99%

Reaching the Unreachable: Strategies for HCV Eradication in Patients With Refractory Opioid Addiction—A Real-world Experience

Sandmann

Deppe

Beier

et al. 2021

Open Forum Infectious Diseases

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“…The identified main risk factors contributing to new cases of HCV infection in Spain are history of sexually acquired infections [incidence rate ratio (IRR) = 18.2, 95%CI: 1.9-172.1; P = 0.01)], male gender (IRR = 8.3, 95%CI: 1.4-54.2; P = 0.03)] and sharing chem-sex drugs (IRR: 4.9, 95%CI: 1.2-20.8; P = 0.03)[ 92 ]. In the Netherlands, homosexual men also have the highest incidence and the highest HCV reinfection rate despite universal and unrestricted access to DAAs, stressing the need for additional preventive measures[ 93 , 94 ].…”

Section: The Efforts To Construct Micro and Macro-elimination Programs Throughout The Worldmentioning

confidence: 99%

Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination

Tijera¹,

Servín-Caamaño²,

Servín-Abad³

2021

WJG

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Chronic viral hepatitis is a significant health problem throughout the world, which already represents high annual mortality. By 2040, chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria, vitellogenesis-inhibiting hormone, and tuberculosis altogether. In this review, we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups, the goals set by the World Health Organization for the year 2030, and the key points to achieve them, such as timely access to antiviral treatment of direct-acting antiviral, which represents the key to achieving hepatitis C virus elimination. Likewise, we review the strategies to prevent transmission and achieve control of hepatitis B virus. Finally, we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs.

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HCV micro-elimination in individuals with HIV in the Netherlands 4 years after universal access to direct-acting antivirals: a retrospective cohort study

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Cited by 50 publications

References 29 publications

Outcomes of an HCV elimination program targeting the Viennese MSM population

Outcomes of an HCV elimination program targeting the Viennese MSM population

Reaching the Unreachable: Strategies for HCV Eradication in Patients With Refractory Opioid Addiction—A Real-world Experience

Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination

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