HCV Infection and the Incidence of CKD

Butt, Adeel A.; Wu, Xiaoqiang; Fried, Linda F.

doi:10.1053/j.ajkd.2010.09.023

Cited by 103 publications

(107 citation statements)

References 24 publications

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“…The prevalence rate of HCV among patients undergoing hemodialysis within a U.S. hemodialysis network was reported as 7.8 percent (range: 5.5 to 9.8 percent) (Finelli, Miller, et al 2005), and it is estimated that more than 60,000 HCV-infected patients will require hemodialysis by 2020 (Butt, Wang, et al 2011). A significant relationship has been observed between HCV infection and increased mortality among patients on long-term dialysis (Fabrizi, Dixit, et al 2012).…”

Section: Patients With Advanced Chronic Kidney Diseasementioning

confidence: 99%

Development of Novel Combination Therapies

2011

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Section: Patients With Advanced Chronic Kidney Diseasementioning

confidence: 99%

Development of Novel Combination Therapies

2011

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“…Two studies did not account for important potential confounders in their analyses (20,21). Nine studies (22)(23)(24)(25)(26)(27)(28)(29)(30) fulfilled the inclusion criteria. The complete list of articles is available on request.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Four longitudinal reports (613,368 unique patients) addressed the incidence of low eGFR in HCVinfected patients (24,25,27,28), and four cross-sectional surveys (93,919 unique patients) reported on the effect of HCV on proteinuria (22,26,29,30). The list of the 486 references is available from the authors on request.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Tsui et al (24) defined the outcome as the onset of stage 5 CKD (hemodialysis or renal transplantation). In the other studies (22,23,(25)(26)(27)(28), reduced eGFR was defined as a minimum eGFR value ,60 ml/min per 1.73 m 2 , using the four-variable Modified Diet in Renal Disease equation, according to the clinical practice guidelines of the National Kidney Foundation (32).…”

Section: Summary Estimates Of Outcomesmentioning

confidence: 99%

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Hepatitis C Virus Infection and Kidney Disease

Fabrizi

Martin

Dixit

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Hepatitis C virus (HCV) infection and kidney disease are both highly prevalent diseases. The association between HCV and GN has been supported by previous research but little is known about the relationship between HCV and kidney disease.Design, setting, participants, & measurements A systematic review of the published medical literature was conducted to determine if HCV is associated with increased likelihood of kidney disease in the general population. A random-effects model was used to generate a summary estimate of the relative risk for kidney disease, defined as an estimated GFR ,60 ml/min per 1.73 m 2 or proteinuria, with HCV across the published studies.Results Nine clinical studies (817,917 unique individuals) were identified. Pooling of study results demonstrated the absence of a relationship between HCV seropositive status and reduced estimated GFR (adjusted relative risk, 1.12; 95% confidence interval, 0.91, 1.38; P=0.28) according to the random-effects model. HCV seropositive serology was an independent and significant risk factor for proteinuria (defined by urine dipstick test or spot urine albumin/creatinine ratio) in the general population, with a summary estimate for adjusted relative risk of 1.47 (95% confidence interval, 1.12, 1.94; P=0.006). Significant heterogeneity was observed between studies (Ri=0.82; P value by Q test, ,0.001).Conclusions This meta-analysis shows that HCV is independently associated with proteinuria but not with reduced GFR in the general population. Substantial heterogeneity occurred.

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“…In our present study Among the co-morbidities of HCV patients CLD and CKD were in higher percentages. Butt et al [24] added in his study that anti-HCV status was associated with low glomerular filtration rate. Our HCV patients with CKD need a special care.…”

Section: Discussionmentioning

confidence: 98%

Current Prevalence of HCV in Patients with Liver Disease and its Related Profile

Narayanasamy¹,

J²,

M³

et al. 2016

Colorec Cancer

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Background: To study the prevalence of HCV in patients with Liver disease, HCV related patient's profile, age, obesity, habits, biological marker, Co-morbidities, Diabetes, Obesity, Hepato Celluar Carcinoma (HCC) and detecting Liver stiffness. Material and methods:Prevalence of HCV was studied in 69,353 patients with liver disease. Tests done and results were recorded.Results: Overall prevalence of HCV in patients with liver disease was 1.3% in our present study, conducted in South Indian population. Statistical significance was found between screened patients and serological and virological reactive patients. Liner prevalence of HCV was observed and double fold increases in the year 2013. No bad habits were found in 49.7% and unhealthy habits in 50.3%. Co-morbidies found in 60.1% and no co-morbidies in 39.9%.Prevalence of Diabetes mellitus and obese were 20.9% and 34.8% respectively in HCV reactive patients with liver disease. 2.5% of patients were with Hepato Cellular Carcinoma (HCC). Elevation of biological markers were studied (S. protein-63.9%, ALT -50.6%, AST-50.3%. Alkaline phosphatase-(M-35.5%, F-39.1%). As year progresses prevalence of HCV increased in both gender and HCV reactivity were higher in male than female. A statistical significant was found in detecting liver stiffness by fibroscan. Conclusion:Liner increase of HCV was found. Higher numbers of patients were with unhealthy habits among the study population. CLD and CKD were found in higher percentage in HCV reactive patients with liver disease. 1/5 and 1/3 of our HCV reactive patients were Diabetic and obese respectively. Fibroscan was the best non-invasive marker in detecting liver stiffness in our study.

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HCV Infection and the Incidence of CKD

Cited by 103 publications

References 24 publications

Development of Novel Combination Therapies

Development of Novel Combination Therapies

Hepatitis C Virus Infection and Kidney Disease

Current Prevalence of HCV in Patients with Liver Disease and its Related Profile

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