HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis

Nawaz, Rabia; Zahid, Sadia; Idrees, Muhammad; Rafique, Shazia; Shahid, Muhammad; Ahad, Ammara; Amin, Irum; Almas, Iqra; Afzal, Samia

doi:10.1007/s00011-017-1029-3

Cited by 17 publications

(14 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence is as low as 0.1–1% in northern Europe to 2.5–3.5% in southern Europe. Amongst the most affected countries is Egypt, with 22% of its population infected, followed by Pakistan and China, with more than 3% of their population infected with HCV [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…A lipid bilayer envelope surrounds a capsid. The viral envelope bears E1 and E2 glycoprotein complex that plays a fundamental role in viral and host cell interaction [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Viral genome, comprised of 9600 nucleotides, encodes a 3000 aminoacid polyprotein, which is post-translationally modified into three structural proteins and six non-structural proteins. Structural proteins, Core, E1, and E2, create the capsid and the envelope, while non-structural proteins, NS2, NS3, NS4A, NS4B, NS5A, and NS5B, are the building blocks for the particle and play a vital role as genome replicating proteins [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Schietroma¹,

Scheri²,

Pinacchio³

et al. 2018

TOVJ

View full text Add to dashboard Cite

Introduction:Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually. Chronic infection can result in cirrhosis and hepatocellular carcinoma.Explanation:Epidemiological studies have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC), mainly through chronic inflammation, cell deaths, and proliferation. Despite the new direct-acting antiviral drugs (DAA’s) being able to clear the HCV, HCC recurrence rate in these patients is still observed.Conclusion:In this review we highlighted some aspects that could be involved in the onset of HCV-induced HCC such as immune system, viral factors and host genetics factors.Moreover, we focused on some of the last reports about the effects of DAA’s on the HCV clearance and their potential implications in HCC recurrence.

show abstract

Section: Introductionmentioning

confidence: 99%

“…A lipid bilayer envelope surrounds a capsid. The viral envelope bears E1 and E2 glycoprotein complex that plays a fundamental role in viral and host cell interaction [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Schietroma¹,

Scheri²,

Pinacchio³

et al. 2018

TOVJ

View full text Add to dashboard Cite

show abstract

“…17,18 Increasing evidence has shown that the inltration of inammatory cells in NASH mainly involves the secretion of inammatory factors in the accumulating macrophage cells. [19][20][21] It is worth noting that the secretion of inammatory factors mainly includes the production of proinammatory factors and the release of inammatory factors. GVS-12, a new type of PPARg, markedly down-regulated the mRNA expression of IL-1b, IL-6 and TNF-a in PA-induced HepG2 cells.…”

Section: Discussionmentioning

confidence: 99%

GVS-12 attenuates non-alcoholic steatohepatitis by suppressing inflammatory responses via PPARγ/STAT3 signaling pathways

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Such observations raised a question whether the hepatic effects of DAAs are attributed only to the resolution of the virus and its inflammatory consequences or are due to some direct effects of the drugs [ 12 , 13 ]. Consequently, the present study aimed at investigating the effects of Sof and Dac on liver injury induced by thioacetamide (TAA) in rats and possible mechanisms underlying their effects.…”

Section: Introductionmentioning

confidence: 99%

Hepatic effect of sofosbuvir and daclatasvir in thioacetamide-induced liver injury in rats

Ibrahim¹,

Abdel-Aziz²,

El-Sheikh³

et al. 2018

ceh

View full text Add to dashboard Cite

IntroductionThe study aimed at investigating the hepatic effect of direct acting anti-hepatitis C virus drugs (DAAs), sofosbuvir (Sof) and daclatasvir (Dac), in thioacetamide (TAA)-induced liver injury in rats.Material and methodsAnimals were allocated to 7 groups: a normal control group, a TAA group (receiving TAA 50 mg/kg, i.p. twice weekly), two TAA groups receiving either a low or a high dose of Sof (Sof-L and Sof-H; 41.1 mg/kg and 82.2 mg/kg, respectively), two TAA groups receiving either a low or a high dose of Dac (Dac-L and Dac-H; 6.2 mg/kg and 12.4 mg/kg, respectively), and a TAA group receiving both Sof-L and Dac-L.ResultsAfter 6 weeks, TAA significantly elevated the serum activities of liver enzymes, along with histopathological evidence of liver injury. These findings were associated with a significant increase in a fibrotic marker (tissue inhibitor metalloproteinase-1 – TIMP-1), proinflammatory cytokine (tumor necrosis factor alpha – TNF-α), and oxidative stress parameters (malondialdehyde [MDA] content, and superoxide dismutase [SOD] and catalase activities) in hepatic tissue. TAA rats treated with Sof-L, Dac-L, Dac-H and a combination of Sof-L plus Dac-L showed significant amelioration of TAA-induced liver injury. Their effects were accompanied by a significant reduction in TIMP-1, TNF-α and oxidative stress parameters in hepatic tissue. Interestingly, Sof-H caused no improvement in TAA-induced hepatic injury.ConclusionsThe hepatic effects of Sof and Dac in TAA-induced liver injury appeared to be mediated by anti-oxidant effects, and inhibition of TNF-α and TIMP-1.

show abstract

HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis

Cited by 17 publications

References 112 publications

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

GVS-12 attenuates non-alcoholic steatohepatitis by suppressing inflammatory responses via PPARγ/STAT3 signaling pathways

Hepatic effect of sofosbuvir and daclatasvir in thioacetamide-induced liver injury in rats

Contact Info

Product

Resources

About