HCV genotypes and age distribution in patients of Vienna and surrounding areas

Haushofer, Alexander; Kopty, Camel; Hauer, R.-W.; Brünner, H.; Halbmayer, Walter‐Michael

doi:10.1016/s1386-6532(00)00154-2

Cited by 31 publications

(36 citation statements)

References 33 publications

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“…Another interesting nding of this study was that genotype 1 infections were more common in older patients, which is very similar to the ndings in HCV infected patients in Vienna and the surrounding areas (23), due to two reasons: patients with genotypes 2 and 3 infection are more responsive to the standard combination of PEG-INF/ RBV therapy compared to genotype 1 infection, and the most HCV infections through blood transfusion are caused by 1 (14,18,23). Carrion et al (24) found that the prevalence rate of genotype 1 increased with age amongst the European population.…”

Section: Discussionsupporting

confidence: 82%

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Most common HCV genotypes in patients from north-eastern Croatia

Perić

Bošnjak

Džijan

et al. 2014

AMA

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Objective. e aims of this study were to determine the HCV-RNA viral load, genotype distribution, risk factors and symptoms of HCV-RNA positive viral load in HCV antibody-positive patients from north-eastern Croatia. Materials and methods. From January 2009 to December 2011, 203 HCV antibody-positive patients (130 men and 73 women; median age 44.5 years) were analyzed for HCV-RNA by the COBAS TaqMan HCV test and genotyped by the Linear Array HCV Genotyping test (both from Roche). All patients completed a structured questionnaire about risk factors and symptoms. Results.e HCV-RNA percentage was 61.1% and was similar for men and women. e HCV-RNA viral load increased with age: while 55% of 20-50 year old patients were HCV-RNA positive, 73% of patients >50 years were positive (p=0.021). Genotype 1 was the most prevalent genotype (79.8%), followed by 3 (12.9%), 4 (6.5%), and 2 (0.8%); genotypes 5 and 6 were not determined. Patients with genotype 1 (median, 50 years) were older than patients with 3 (median, 33.5 years) or 4 (median, 38 years). e blood transfusions performed in Croatian hospitals before 1993 was signi cantly associated with HCV-RNA positive viral load (p<0.05). Conclusion.ese data indicated an elevated prevalence of genotype 1 in elderly HCV-RNA positive patients and it may continue to rise. Using RNA-based detection in HCV positive-antibody patients would allow early detection of HCV in the acute stage of HCV disease and the increased risk of HCV genotyperelated treatment failure.

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Section: Discussionsupporting

confidence: 82%

“…Secondly, genotype 4 infections spread by migration, which may explain why these infections were more common in younger patients (25)(26)(27). irdly, genotype 1 infections are more refractory to PEG-INF/RBV (23) and may thus remain detectable in older HCV infected patients.…”

Section: Discussionmentioning

confidence: 99%

Most common HCV genotypes in patients from north-eastern Croatia

Perić

Bošnjak

Džijan

et al. 2014

AMA

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“…We aimed to gather recent data in our hospital on the predominant genotypes in order to determine if genotype distribution has changed and whether there is any association of genotype with gender and age. In some studies, it was determined that patients infected with genotypes 1b or 2 were older than patients infected with genotypes 1a, genotype 3, or genotype 4 (15,16). Analysis of the genotype distribution according to age showed that patients infected with genotype 1 were significantly older than patients infected with non-1 genotypes (mean age±SD: 52,0±14,1 years vs. 43,4±17,0 years; p=0,001).…”

Section: Discussionmentioning

confidence: 99%

Possible transmission risks and genotype distribution of hepatitis C virus infection in Western Turkey

Altuğlu¹,

Sertöz²,

Aksoy³

et al. 2013

Turk J Gastroenterol

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“…Genotypes 1-3 occur globally, while HCV genotype 4 is common in the Middle East and Africa [6][7][8] , genotypes 5 and 6 are found in South Africa [9] and Southeast Asia [10] , respectively. Subtypes 1a and 3a are associated with intravenous drug use, whereas subtype 1b is common in blood donors in Europe [11][12][13] . In Indonesia, the genotypes 1-3 are found in both blood donors and patients diagnosed with CH, LC, and HCC [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Virus Genotype in Blood Donors and Associated Liver Disease in Indonesia

Utama¹,

Budiarto²,

Monasari³

et al. 2008

Intervirology

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Objective: The aim of this study was to investigate the distribution of hepatitis C virus (HCV) genotype and the possible association between genotype and HCV-associated liver disease in Indonesia. Methods: 32 anti-HCV-positive asymptomatic carriers (AC), 55 chronic hepatitis (CH), 41 liver cirrhosis (LC), and 35 hepatocellular carcinoma (HCC) patients were included in this study. HCV genotyping was performed by phylogenetic analysis of the NS5B and 5′-UTR regions. Results: The HCV subtype 1b (36.5%), based on NS5B region, was the most prevalent, followed by subtypes 3k (15.4%), 2a (14.4%), 1a (12.5%) and 1c (12.5%), and 2e (4.8%). Subtypes 2f, 3a, 3b, and 4a were also found in some of the samples. HCV subtypes 3k (40.0%) and 1a (35.0%) were the two major subtypes in AC. HCV subtype 1b was not found in AC, but it was common in CH (31.3%), LC (50.0%), and HCC (57.1%). Conclusion: HCV subtype 1b was prevalent in samples of HCV-associated liver disease patients, including CH, LC and HCC. The percentage of subtype 1b was increased with the disease severity (AC < CH < LC < HCC).

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HCV genotypes and age distribution in patients of Vienna and surrounding areas

Cited by 31 publications

References 33 publications

Most common HCV genotypes in patients from north-eastern Croatia

Most common HCV genotypes in patients from north-eastern Croatia

Possible transmission risks and genotype distribution of hepatitis C virus infection in Western Turkey

Hepatitis C Virus Genotype in Blood Donors and Associated Liver Disease in Indonesia

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