HCV Genotype 3a; Have Mild to Moderate Grades of Steatosis in Hyderabad

Abstract

The aim of this study was to see the correlation between hepatic steatosis in chronic HCV infection and HCV genotypes. Study Design: It was a prospective observational study done. Setting: Isra University Hospital and histopathology laboratory. Period: May to November 2014. Material & Methods: The study was conducted on 87 liver biopsy specimens of patients infected with chronic HCV. The biopsy samples were collected from department of Pathology, Isra University. H&E stained sections of liver biopsies were evaluated to determine Grade and Stage of chronic hepatitis C and grade of steatosis. Blood samples of those patients were collected from Isra University hospital and Asian Institute of Medical Sciences (AIMS), Hyderabad to determine the HCV genotype, platelet count and liver function test including ALT, AST and GGT. Results: It was found that majority of the patients 38 (43.6%) had genotype 3a infection followed by 3b, 1a, 1b and Un-typeable genotypes. Hepatic steatosis was divided into categories according to Brunt's classification. It was found that 39 (44.8%) patients had grade 0 steatosis while 48 out of 87 patients presented with steatosis. It was found that 29 (33%) presented with grade 1 steatosis followed by grade 2 and 3. Steatosis was most frequently seen with genotype 3a (26.4%) and presented with mild to moderate grade. Conclusions: The present study concludes that hepatic steatosis is more frequent in genotype 3a and presents with mild to moderate grade.