HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization

Valle-Millares, Daniel; Brochado-Kith, Óscar; Gómez-Sanz, Alicia; Martín‐Carbonero, Luz; Ryan, Pablo; Santos, Ignacio; Castro, Juan Manuel; Troya, Jesús; Mayoral-Muñoz, Mario; Cuevas, Guillermo; Martínez-Román, Paula; Sanz, Jesús; Muñoz-Muñoz, María; Jiménez-Sousa, María Ángeles; Resino, Salvador; Briz, Verónica; Fernández‐Rodríguez, Amanda

doi:10.1016/j.biopha.2021.112405

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…Further, the results of MNDR (Mammalian ncRNA-disease repository) suspect that the cases of intellectual disability have more chances to occur in couples who have had severe or prolonged COVID-19 infection ( Vastrad et al, 2020 , Vastrad et al, 2020 , Wu et al, 2021 Apr 12 , Fernández-Pato et al, 2022 Dec , Demirci et al, 2021 Mar 17 , Chow and Salmena, 2020 Aug 26 ), or HIV infection ( Valle-Millares et al, 2022 ). The intellectual disability may also occur in babies who are born to a family that has a history of any metabolic syndrome ( Y. Li et al, 2020 ) like type II diabetes ( Lan et al, 2022 ), progressive supranuclear palsy ( Nonaka et al, 2022 ), Parkinson’s disease ( Schulze et al, 2018 ), oral lichens planus ( Gholizadeh et al, 2020 ), psoriasis ( Lin et al, 2021 ), penile squamous cell carcinoma ( Ayoubian et al, 2021 ), and pre-eclampsia ( Pan et al, 2022 ) because of the association of these diseases with hsa-miR-8485 and hsa-miR-12136.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID)

Garg¹,

Jamal²,

Srivastava³

2022

IBRO Neuroscience Reports

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Section: Discussionmentioning

confidence: 99%

Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID)

Garg¹,

Jamal²,

Srivastava³

2022

IBRO Neuroscience Reports

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“…The scientists have already established several miRNAs and their roles concerning HIV-1 and HCV mono-infection. Although sex-specific biasness has been observed in the miRNA expression of HIV/HCV-co-infected patients, role of some miRNAs is believed to be conserved in the mono-infections and also has their potential contribution in HIV/HCV co-infection 98 ( Figure 5 ).…”

Section: Role Of Mirnas In Hiv/hcv Co-infectionmentioning

confidence: 99%

The involvement of microRNAs in HCV and HIV infection

Joshi

Tak

Mukherjee

2022

Therapeutic Advances in Vaccines and Immunotherapy

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Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in miRNA expression can lead to unfavorable outcomes; hence, this exact inevitable nature has made various studies a focal point. A considerable improvement in comprehending HIV and HCV mono-infection pathogenesis is seen using miRNAs. The prominent reason behind HIV/HCV co-infection is seen to be their standard route of transmission, while some pieces of evidence also suspect viral interplay between having a role in increased viral infection. This review highlights the involvement of microRNAs in HIV/HCV co-infection, along with their contribution in HIV mono- and HCV mono-infection. We also discuss miRNAs that carry the potentiality of becoming a biomarker for viral infection and early disease progression.

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“…Similarly, in contrast to non-responders, individuals who respond to antiviral treatment do not show augmented miR-155 in peripheral monocytes [94]. A study that analyzed the evolution of the miRNA signature in circulating peripheral blood mononuclear cells from HIV-1/HCV-coinfected patients before and after HCV eradication with DAAs also found that the miRNA profiles were normalized in females after achieving virus eradication, but not completely in males [102]. This study speculated on the possibility that the lack of normalization in males is related to a high risk of developing liver-related complications.…”

Section: Micrornamentioning

confidence: 99%

Circulating MicroRNAs as a Tool for Diagnosis of Liver Disease Progression in People Living with HIV-1

Martı́nez

Tural

Franco

2022

Viruses

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MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression by binding specific cell mRNA targets, preventing their translation. miRNAs are implicated in the regulation of important physiological and pathological pathways. Liver disease, including injury, fibrosis, metabolism dysregulation, and tumor development disrupts liver-associated miRNAs. In addition to their effect in the originating tissue, miRNAs can also circulate in body fluids. miRNA release is an important form of intercellular communication that plays a role in the physiological and pathological processes underlying multiple diseases. Circulating plasma levels of miRNAs have been identified as potential disease biomarkers. One of the main challenges clinics face is the lack of available noninvasive biomarkers for diagnosing and predicting the different stages of liver disease (e.g., nonalcoholic fatty liver disease and nonalcoholic steatohepatitis), particularly among individuals infected with human immunodeficiency virus type 1 (HIV-1). Liver disease is a leading cause of death unrelated to acquired immunodeficiency syndrome (AIDS) among people living with HIV-1 (PLWH). Here, we review and discuss the utility of circulating miRNAs as biomarkers for early diagnosis, prognosis, and assessment of liver disease in PLWH. Remarkably, the identification of dysregulated miRNA expression may also identify targets for new therapeutics.

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HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization

Cited by 3 publications

References 55 publications

Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID)

Deciphering the role of precursor miR-12136 and miR-8485 in the progression of intellectual disability (ID)

The involvement of microRNAs in HCV and HIV infection

Circulating MicroRNAs as a Tool for Diagnosis of Liver Disease Progression in People Living with HIV-1

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