HCV cirrhotic patients treated with direct‐acting antivirals: Detection of tubular dysfunction and resolution after viral clearance

Abstract

Drug related rise 3.7 to 4.5 ng/mg 1, 2 Composite of both disease and drug related rises ** often reported as urinary/serum total KIM-1* *normalized for urinary creatinine excretion KIM-1 kinetics Healthy Volunteers 0.059 to 2.15 ng/mg 3 #U.S. Department of Energy Genomic Science program Tubular cell SNP Recovered Progression to CKD Systemic factors Abbreviations SNP: single nucleotide polymorphisms HCV: Hepatitis C virus CABG: coronary artery bypass graft DAA's: Direct-acting antiviral agents KIM-1 receptor Influence of SNPs encoding KIM-1 receptor (rs2036402) 1172 | LETTER TO THE EDITOR single nucleotide polymorphisms (SNP's) encoding KIM-1 receptor on its expression following interface with these "stimuli". The exact KIM-1 (normalized for urinary creatinine excretion) diagnostic threshold attributable to a single factor remains uncertain. Before ultimate deployment as a point of care assay, there is need for future studies designed to examine the exact contribution of each of these factors to the overall measured and reported serum and urinary KIM-1 excretion.