HCV-associated hepatocellular carcinoma without cirrhosis

El-Refaie, A.; Savage, Kay; Bhattacharya, Satyajit; Khakoo, Salim I.; Harrison, Tim J.; El-Batanony, Mohamed H.; Soliman, E.-S.; Nasr, Sherif; Mokhtar, Nadia; Amer, Kawther; Scheuer, Peter J.; Dhillon, A.P.

doi:10.1016/s0168-8278(96)80005-5

Cited by 77 publications

(35 citation statements)

References 32 publications

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“…The occurrence of cirrhosis before the appear- ance of neoplastic transformation in the majority of patients suggests that this histologic stage, characterized by continuous regeneration and remodeling of the liver, is an important factor in the development of HCC. 31 On the other hand, HCV positive tumors in noncirrhotic livers have been described, 32,33 giving rise to the question of whether the virus has a direct effect on malignant transformation. The biologic properties of HCV proteins are not well understood, and possible cooperation with cellular components are currently under investigation.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection associated with human hepatocellular carcinoma

Pontisso¹,

Belluco²,

Bertorelle³

et al. 1998

Cancer

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Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection associated with human hepatocellular carcinoma

Pontisso¹,

Belluco²,

Bertorelle³

et al. 1998

Cancer

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“…The role of prolonged liver necrosis and regeneration leading to cirrhosis seems to be the most important condition in the multistep process of hepatic carcinomagenesis [51]. However, De Mitri et al [53] and, more recently, Elrefaie et al [54] demonstrated that hepatocellular carcinoma can develop in HCVinfected individuals without the intermediate step of cirrhosis; moreover, in some patients only mild inflammatory alterations were observed at liver biopsy (Fig. 1d).…”

Section: Chronic Hcv Infectionmentioning

confidence: 96%

Viruses and cancers: possible role of hepatitis C virus

Ferri

Civita

Zignego

et al. 1997

Eur J Clin Investigation

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Abstract. Oncogenesis is a multifactorial process in which environmental, genetic and infectious factors are variably involved. A possible role of specific viruses has been suggested in at least 15% of human cancers. Hepatitis C virus (HCV), which is both hepato-and lymphotropic, is responsible for various liver disorders, i.e. chronic hepatitis, cirrhosis and hepatocellular carcinoma, as well as for a constellation of extrahepatic immune-mediated manifestations, among which is mixed cryoglobulinaemia. This is a systemic disorder secondary to a chronic, benign B-lymphocyte proliferation, which in some subjects may evolve to a malignant non-Hodgkin's lymphoma (NHL). Interestingly, recent studies reported the appearance of malignant B-cell neoplasias in patients with type C chronic hepatitis; moreover, in a significant number (from 22% to 50%) of 'idiopathic' NHLs, the presence of HCV infection has been demonstrated. The presence of a geographical etherogeneity in the prevalence of HCV-positive NHL suggests that other co-factors, i.e. genetic and environmental, could be involved in the lymphomagenesis. HCV may exert its oncogenic potential in two different directions, leading to liver cancer or B-cell lymphoma.

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“…The lower rates are found in the western countries, South America and India, while Japan, Middle East and the Mediterranean countries belong to the intermediate group [3,4]. Overall hepatocellular carcinoma is estimated to be the seventh most common cancer in men and the ninth in women [5]. However, in Japan hepatocellular carcinoma is the third most frequent cause of male cancer deaths [6].…”

Section: Epidemiologymentioning

confidence: 99%

Octreotide for Cancer of the Liver and Biliary Tree

Kouroumalis¹

2001

Chemotherapy

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Inoperable liver tumors have an unfavorable natural course despite various therapeutic modalities. Octreotide, a somatostatin analog, has shown considerable antitumor activity on animal models of various hepatic tumors and on isolated cell culture lines. In this paper, a review of the experimental evidence is presented. Moreover clinical papers of case reports of uncontrolled studies of patients are also reviewed. The majority of clinical studies provide evidence of a clinical and biochemical response of liver endocrine tumors while regression of tumor size is a rare event. A randomized controlled trial of octreotide in the treatment of advanced hepatocellular carcinoma has shown a significant survival benefit in the treated patients. Literature reports indicate a stimulatory effect of octreotide on Kupffer cells as a possible antitumor mechanism, but other antiproliferative actions of octreotide have been suggested but not proved. Finally the question of the presence and affinity of somatostatin receptors on liver tumor tissue is discussed. In conclusion, according to our experience, octreotide administration is the best available treatment for advanced inoperable hepatocellular carcinoma and future better patient selection, based on receptor subtypes, might further improve the results.

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HCV-associated hepatocellular carcinoma without cirrhosis

Cited by 77 publications

References 32 publications

Hepatitis C virus infection associated with human hepatocellular carcinoma

Hepatitis C virus infection associated with human hepatocellular carcinoma

Viruses and cancers: possible role of hepatitis C virus

Octreotide for Cancer of the Liver and Biliary Tree

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