HCV Antibody Prevalence and Genotype Evolution in a Teaching Hospital, Calabria Region, Southern Italy Over A Decade (2008-2018)

Marascio, Nadia; Mazzitelli, Maria; Scarlata, Giuseppe Guido Maria; Giancotti, Aida; Barreca, Giorgio Settimo; Lamberti, Angelo Giuseppe; Divenuto, Francesca; Costa, Cristina; Trecarichi, Enrico Maria; Matera, Giovanni; Liberto, Maria Carla; Torti, Carlo

doi:10.2174/1874285802014010084

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Enrolled patients, attending the University Hospital of Catanzaro, were randomly selected from a list through a systematic 1:7 sampling procedure. The selected sample is representative of the whole HCV1b cohort, including 41.7% of males versus 54.0% of females with an overall median age 68 (31–84) years [ 12 ]. Patients were naïve to all treatments (25/41) or treated with IFN (3/41) and pegIFN-α/RBV (13/41).…”

Section: Methodsmentioning

confidence: 99%

Phylogenetic and Molecular Analyses of More Prevalent HCV1b Subtype in the Calabria Region, Southern Italy

Marascio

Costantino

Taffon

et al. 2021

JCM

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Hepatitis C virus subtype 1b (HCV1b) is still the most prevalent subtype worldwide, with massive expansion due to poor health care standards, such as blood transfusion and iatrogenic procedures. Despite safe and effective new direct antiviral agents (DAA), treatment success can depend on resistance-associated substitutions (RASs) carried in target genomic regions. Herein we investigated transmission clusters and RASs among isolates from HCV1b positive subjects in the Calabria Region. Forty-one NS5B and twenty-two NS5A sequences were obtained by Sanger sequencing. Phylogenetic analysis was performed using the maximum likelihood method and resistance substitutions were analyzed with the Geno2pheno tool. Phylogenetic analysis showed sixteen statistically supported clusters, with twelve containing Italian sequences mixed with foreign HCV1b isolates and four monophyletic clusters including only sequences from Calabria. Interestingly, HCV1b spread has been maintained by sporadic infections in geographically limited areas and by dental treatment or surgical intervention in the metropolitan area. The L159F NS5B RAS was found in 15 isolates and in particular 8/15 also showed the C316N substitution. The Y93H and L31M NS5A RASs were detected in three and one isolates, respectively. The A92T NS5A RAS was found in one isolate. Overall, frequencies of detected NS5B and NS5A RASs were 36.6% and 22.7%, respectively. For the eradication of infection, improved screening policies should be considered and the prevalence of natural RASs carried on viral strains.

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Section: Methodsmentioning

confidence: 99%

Phylogenetic and Molecular Analyses of More Prevalent HCV1b Subtype in the Calabria Region, Southern Italy

Marascio

Costantino

Taffon

et al. 2021

JCM

Self Cite

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“…In industrialized countries, the most prevalent subtypes are HCV1a, 1b, 2c, 3a, and 4a[ 19 , 20 ]. HCV1b and 2c are mainly transmitted by blood transfusion and infect older population groups, whereas HCV1a, 3a and 4a are prevalent in intravenous drug users[ 21 , 22 ]. Low standards for healthcare procedures have allowed HCV spreading among patients in hemodialysis units[ 23 ].…”

Section: Epidemiologymentioning

confidence: 99%

Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice

Marascio¹,

Rotundo²,

Quirino³

et al. 2022

WJG

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Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

Scarlata,

Cicino,

Spagnuolo

et al. 2024

Hepatoma Res

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Hepatocellular carcinoma (HCC) is a primary liver cancer that occurs with a frequency of 85% in patients with liver cirrhosis. It is the sixth most common type of cancer globally. Asia is the continent with the highest incidence (72%), followed by Europe (8%) and Africa (5%). Men are four times more likely than women to develop this cancer, especially in the 70-80 age group. Risk factors include alcoholic liver disease, tobacco use, genetic predisposition, dysmetabolic comorbidities such as type 2 diabetes mellitus and obesity, hepatitis B virus and hepatitis C virus infections, and non-alcoholic fatty liver disease. Unhealthy dietary regimens and gut dysbiosis are additional risk factors that have been recently investigated. These two factors are closely related because the gut microbiota performs several biological functions, including nutrient metabolism, a process that promotes gut homeostasis, known as eubiosis. With regard to the correlation between diet, gut microbiota, and HCC development, there are several mechanisms that have not yet been fully elucidated. This narrative review aims to evaluate the impact of diet and gut microbiota changes in the development of HCC. Our analysis, performed on several clinical and pre-clinical studies, showed that a high-fat diet promotes gut dysbiosis and hepatic fat accumulation, leading to the progression from simple steatosis to HCC, while the Mediterranean diet, rich in fiber and monounsaturated fatty acids, had a protective role. For this reason, international employment of this dietary regimen for therapeutic purposes should be encouraged.

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HCV Antibody Prevalence and Genotype Evolution in a Teaching Hospital, Calabria Region, Southern Italy Over A Decade (2008-2018)

Cited by 4 publications

References 35 publications

Phylogenetic and Molecular Analyses of More Prevalent HCV1b Subtype in the Calabria Region, Southern Italy

Phylogenetic and Molecular Analyses of More Prevalent HCV1b Subtype in the Calabria Region, Southern Italy

Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice

Impact of diet and gut microbiota changes in the development of hepatocellular carcinoma

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