HCV Antibody Positive Rate Observed in Periodic Checkup in Kitakyushu.

Ueda, Ryoji; Fujishiro, Kazuya; Mizoue, Tetsuya; Takada, Kazumi

doi:10.1539/joh1959.36.6_446

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“…The influence of chronic hepatitis virus infection is expected to be much smaller than that of fatty liver. It has been reported, from areas of relatively high prevalence of hepatitis virus in Japan, that the prevalence of hepatitis B surface antigen (HBsAg) positivity in subjects aged 20-40 years was less than 4%13), and the prevalence of anti-hepatitis C virus antibody (anti-HCVAb) positivity was less than 2% in this groupl3, 14) The present study among employees aged 18-39 found that: 1) ALT and AST levels are well-correlated with sex and BMI, and therefore health professionals in occupational settings should carefully assess the liver transferase activity of employees; 2) abnormal liver transferase activity may occur in up to 15.9% of males whereas it is very rare in females, suggesting liver function tests should be introduced for male employees less than 40 years of age.…”

Section: Resultsmentioning

confidence: 91%

Liver Transferase Activity in Healthy Japanese Employees Aged 18-39 Years.

et al. 1998

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The aims of the present study were to identify correlates of alanine aminotransferase (ALT or GPT) and aspartate aminotransferase (AST or GOT) activities among a healthy working population aged 18-39, and to discuss liver transferase abnormalities.Subjects included 1,009 employees of a company in Fukushima, Japan. Pregnant women, employees exposed to organic solvents, and employees with a history of liver diseases were excluded. Serum ALT and AST levels were measured by an enzymatic method. Other information including BMI, job type and lifestyles was recorded. Mean ALT and AST levels were significantly higher for males than females (P<0.001). Multiple linear regression analysis revealed that sex and BMI explained 45% and 31% of the variability in ALT and AST, respectively. The prevalence of abnormal ALT levels (>40 IU) was 16.3% for males and 0.4% for females. Sex, BMI, and shift work were independently associated with abnormal ALT levels by logistic regression analysis. It is concluded that ALT and AST levels are well-correlated with sex and BMI, and that abnormal liver transferase activity is prevalent in male employees but rare in females, suggesting that liver function tests should be introduced for male employees under 40 years of age.

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Section: Resultsmentioning

confidence: 91%