Hcp1 regulates flagella of Aeromonas veronii TH0426 to reduce virulence

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

“…aeruginosa effectors ExoT/ExoS, with ADP-ribosyltransferase and GTPase activities Braun et al ( 2002 ); Burr et al ( 2003 ); Sha et al ( 2007 ) aopP and other T3SS effector proteins T3SS effector protein Interferes with host cell signaling and in other ways modifies/regulates pathogenicity Matys et al ( 2020 ); Rangel et al ( 2019 ); Zhang et al ( 2022a ) T6SS Structural Components that result in effector secretion A bacterial machine that constitutes a phage-like injectosome complex that serves to translocate effectors directly into competing bacterial cells as well as eukaryotic host cells Suarez et al ( 2008 ) hcp Hemolysin coregulated protein Surface-exposed structural components that might be released in culture supernatants or into eukaryotic cells during translocation Cai et al ( 2022 ); Tekedar et al ( 2018 ) vgrG Valine-glycine repeat protein G Acts as a conduit for T6SS effector proteins to be transported from the bacterial cytoplasm into the target cell. Can be involved in T6SS expression regulation Tekedar et al ( 2018 ) evpP/ T6SS-associated effectors Secreted T6SS effector proteins Various functions depending on the specific effector; de-ubiquitinase activity, carries a payload of toxic proteins/enzymes that disrupt cell function, degrades cell components, and modifies the environment to be more favorable Matys et al ( 2020 ); Wang et al ( 2023a ) …”