HClO-triggered interventional probe enabled early detection and intervention of atherosclerosis

Abstract

Foam cell formation and further accumulation in the subendothelial space of the vascular wall is a hallmark of early atherosclerosis (AS). Targeting foam cell formation can be a promising approach...

Fluorescent probes for imaging: a focus on atherosclerosis

“…In addition to LDs, overexpression of ROS, such as hydrogen peroxide (H 2 O 2 ), negative ions of oxygen (O 2 ˙ − ), hypochlorite (HClO) and peroxynitrite (ONOO − ), is also a characteristic of atherosclerosis, which can oxidize lipoproteins, impair vascular endothelial function and reduce plaque stability. 42,43 HClO is considered a good indicator for imaging atherosclerotic plaques. 44 Using rhodamine and coumarin as a double-emission fluorescence skeleton, Gui et al 45 designed a ClO − -activated ratiometric fluorescent probe (Rx-NCE) for imaging plaques under ER stress (Fig.…”

Detection and Imaging of Active Substances in Early Atherosclerotic Lesions Using Fluorescent Probes

“…HClO can promote the formation of atherosclerotic lesions by damaging vascular endothelial function, oxidizing lipoprotein, reducing plaque stability and other ways, and can be used as one of the indicators to evaluate atherosclerosis. [74] Liu et al were the first to propose a sequential high-specificity dualreporter molecular unlock platform called iSHERLOCK that can accurately identify AS plaques by detecting LD and HClO by fluorescence "on-off" and ratio, respectively. [75] As shown in Figure 3A, the BODIPY skeleton is attached to one side with a pmethylidene styrene group as a recognition target of HClO.…”

“…HClO can promote the formation of atherosclerotic lesions by damaging vascular endothelial function, oxidizing lipoprotein, reducing plaque stability and other ways, and can be used as one of the indicators to evaluate atherosclerosis [74] . Liu et al.…”

An AIE Controlled “Off‐On” Cu2+‐Sensitive Probe for Early Detection of Renal Fibrosis

“…Based on previous research, silver sulfide quantum dots (Ag 2 S QDs) have AIE properties, excellent biocompatibility, stable photoluminescence, high brightness, and controllable performance. [ 12 ] Compared to organic fluorophores, [ 13 ] the advantages of quantum dots due to their unique photophysical properties are usually manifested in photostability and fluorescence activity. [ 14 ] In addition, Ag 2 S QDs also have long‐wavelength fluorescence emission, so they can be applied to fluorescence imaging in vivo.…”