HClO/ClO<sup>–</sup>-Indicative Interpenetrating Polymer Network Hydrogels as Intelligent Bioactive Materials for Wound Healing

Wang, Nan; Shan, Yi-Min; Li, Kun; Tian, Jun; Yu, Xiao‐Qi; Wei, Xi

doi:10.1021/acsabm.9b00806

Cited by 15 publications

(7 citation statements)

References 51 publications

(56 reference statements)

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“…Combination of sodium alginate (SA) and RhB-AC placed into the interpenetrating polymer network (IPN) hydrogels allowed to obtain a biocompatible material for HClO/ClO − determination [ 229 ]. This material is suitable for use as smart wound dressings or as a drug scaffold with controlled drug release.…”

Section: Optical Polymer-based Sensors In Environmental Objects and B...mentioning

confidence: 99%

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

2022

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Polymers are widely used in many areas, but often their individual properties are not sufficient for use in certain applications. One of the solutions is the creation of polymer-based composites and nanocomposites. In such materials, in order to improve their properties, nanoscale particles (at least in one dimension) are dispersed in the polymer matrix. These properties include increased mechanical strength and durability, the ability to create a developed inner surface, adjustable thermal and electrical conductivity, and many others. The materials created can have a wide range of applications, such as biomimetic materials and technologies, smart materials, renewable energy sources, packaging, etc. This article reviews the usage of composites as a matrix for the optical sensors and biosensors. It highlights several methods that have been used to enhance performance and properties by optimizing the filler. It shows the main methods of combining indicator dyes with the material of the sensor matrix. Furthermore, the role of co-fillers or a hybrid filler in a polymer composite system is discussed, revealing the great potential and prospect of such matrixes in the field of fine properties tuning for advanced applications.

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Section: Optical Polymer-based Sensors In Environmental Objects and B...mentioning

confidence: 99%

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

2022

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“…To demonstrate the functionality of their nanosensor in vivo to detect the presence of ClO − in both digestive and metabolic systems, and during a wound healing response. It has been widely reported that an increased production of ClO − (Wang et al, 2020a) and other ROS molecules occur during wound healing (Niethammer et al, 2009;Love et al, 2013). Through facile feeding, the authors were able to track the production of ClO − within the FIGURE 5 | (A) Schematic of the "multicenter-emitting" carbon dot for the detection of ClO − .…”

Section: Innate Fluorescent Carbon Dots For Ros Detection and Monitoringmentioning

confidence: 99%

Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments

et al. 2021

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Reactive oxygen species (ROS) and dissolved oxygen play key roles across many biological processes, and fluorescent stains and dyes are the primary tools used to quantify these species in vitro. However, spatio-temporal monitoring of ROS and dissolved oxygen in biological systems are challenging due to issues including poor photostability, lack of reversibility, and rapid off-site diffusion. In particular, ROS monitoring is hindered by the short lifetime of ROS molecules and their low abundance. The combination of nanomaterials and fluorescent detection has led to new opportunities for development of imaging probes, sensors, and theranostic products, because the scaffolds lead to improved optical properties, tuneable interactions with cells and media, and ratiometric sensing robust to environmental drift. In this review, we aim to critically assess and highlight recent development in nanosensors and nanomaterials used for the detection of oxygen and ROS in biological systems, and their future potential use as diagnosis tools.

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“…Additionally, the most common strategies for burn therapy in daily treatment are wound dressings, , drug therapy, , dermatoplasty, , and so forth. Among them, wound dressings play a critical role in wound treatment, due to its ability to provide a moist and sterile environment, which is beneficial to granulation tissue growth, skin cell division, and wound healing acceleration. ,, However, only a handful of studies focused on developing hydrogel wound dressings with cooling ability and heat damage reduction capacity. For instance, Khodja et al fabricated a poly(vinyl alcohol)–chitosan-based hydrogel as a potential burn dressing comprising about 95% water .…”

Section: Introductionmentioning

confidence: 99%

Improved Cooling Performance of Hydrogel Wound Dressings via Integrating Thermal Conductivity and Heat Storage Capacity for Burn Therapy

et al. 2022

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Burn injury has become a crucial public health issue worldwide. It is necessary to explore new methods to reduce heat damage and improve healing efficiency during burn injury treatment. In this study, a kind of hydrogel combining heat storage capacity and thermal conductivity was fabricated via a one-pot method for burn therapy. The novel hydrogel was easily prepared by in situ cross-linking polymerization, using poly(ethylene glycol) (PEG) derivatives, oligo(ethylene glycol) methacrylate and 2-(2-methoxyethoxy) ethyl methacrylate, as thermally responsive base materials and hydroxylated multiwall carbon nanotubes (CNT-OH) as thermally conductive fillers. By dispersing CNT-OH, a thermally conductive network was formed in the hydrogel, leading to an increase in the thermal conductivity. The cooling performance, thermal conductivity, heat storage property, swelling performance, rheological and mechanical properties, biocompatibility, in vivo cooling effect, and wound healing properties of the prepared hydrogel were systematically investigated. The hydrogel consisted of thermally responsive PEG derivatives, and CNT-OH performed a function of rapid heat absorption, further reduced thermal damage, and promoted wound healing. The improved cooling performance of the hydrogel was ascribed to the improved thermal conductivity, enhanced heat storage capacity, and good adhesive ability. Thus, the hydrogel has great potential to be practically applied in burn therapy, laser treatment, cooling fabrics, heat-protective clothing, and other emergency scenarios.

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HClO/ClO^–-Indicative Interpenetrating Polymer Network Hydrogels as Intelligent Bioactive Materials for Wound Healing

Cited by 15 publications

References 51 publications

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments

Improved Cooling Performance of Hydrogel Wound Dressings via Integrating Thermal Conductivity and Heat Storage Capacity for Burn Therapy

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HClO/ClO–-Indicative Interpenetrating Polymer Network Hydrogels as Intelligent Bioactive Materials for Wound Healing

Cited by 15 publications

References 51 publications

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

On the Use of Polymer-Based Composites for the Creation of Optical Sensors: A Review

Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments

Improved Cooling Performance of Hydrogel Wound Dressings via Integrating Thermal Conductivity and Heat Storage Capacity for Burn Therapy

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HClO/ClO^–-Indicative Interpenetrating Polymer Network Hydrogels as Intelligent Bioactive Materials for Wound Healing