HClO‐Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image‐Guided Bacterial Ablation in Phagocytes

Wu, Min; Wu, Wenbo; Duan, Yukun; Liu, Xingang; Wang, Meng; Phan, Chi Uyen; Qi, Guobin; Tang, Guping; Liu, Bin

doi:10.1002/adma.202005222

Cited by 75 publications

(50 citation statements)

References 48 publications

(28 reference statements)

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“…In pursuit of higher possibility and convenience for in vivo application, hydrophobic AIE PSs usually need to be encapsulated within nanocarriers to form well-dispersed NPs with good water solubility and biocompatibility. 48,49,51,[136][137][138][139][140][141][142][143][144][145][146][147][148][149][150] More importantly, enhanced fluorescence intensity, promoted ROS generation and EPR effect-mediated tumor accumulation can be readily realized simultaneously after nanofabrication. For example, a hydrophobic AIE PS named TBTC8 with emission over 800 nm was designed and subsequently loaded into DSPE-PEG 2000 formed NPs for the PDT of 4T1 tumor-bearing mice by Liu and coworkers.…”

Section: Hydrophobicmentioning

confidence: 99%

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

et al. 2022

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Section: Hydrophobicmentioning

confidence: 99%

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

et al. 2022

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“…A theranostic AIE PS‐based nanoprobe with hypochlorous acid (HClO) activatable PS was developed and fabricated by encapsulating DFT PSs and HClO‐sensitive molecules, and FFP together using a highly biocompatible Pluronic F‐127 as the matrix. [ 136 ] Macrophage primarily generates HClO as one of the cytotoxic substances against bacterial infection. Owing to the FRET between DTF and FFP, FFP can quench both fluorescence and singlet oxygen generations production in DTF, thus eliminating the phototoxicity of DTF‐FFP NPs in normal cells and tissues even under irradiation conditions.…”

Section: Biomedical Applications Of Molecular Nanoaggregatesmentioning

confidence: 99%

Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

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Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates, causing characteristic photophysical property changes. A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological applications. The chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates, and this is considered detrimental to the drug discovery process. Furthermore, nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility, including enhanced cell permeability, passive tumor targeting, and convenient surface engineering. Herein, we provide an overview of the recent trends in molecular aggregates for biomedical applications. The changes in photophysical properties of conventional fluorophores and their biological applications are discussed, followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics development. Recent trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional fluorophores. Lastly, we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes, with a focus on in vivo utilization.

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“…developed stimuli‐sensitive AIE photosensitizers which could selectively eliminate intracellular bacteria by PDT without attacking host cells. [ 159 ] In this research, HClO‐activatable AIE photosensitizer DTF‐FFP was synthesized. FFP was used as an energy acceptor to quench fluorescence and inhibit ROS production of AIE‐active DTF, exhibiting negligible fluorescence and phototoxicity to normal cells.…”

Section: Aiegens For Bacterial Treatmentmentioning

confidence: 99%

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.

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HClO‐Activated Fluorescence and Photosensitization from an AIE Nanoprobe for Image‐Guided Bacterial Ablation in Phagocytes

Abstract: Scheme 1. A) Preparation of DTF-FFP NPs. B) Upon accumulation at the bacterial inflammatory site, both fluorescence and photosensitization of DTF-FFP NPs were activated by HClO microenvironment produced by phagocyte to effectively image and ablate the bacteria inside invaded phagocytes.

Cited by 75 publications

References 48 publications

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Recent trends in molecular aggregates: An exploration of biomedicine

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

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