HCG-induced ovulation in two rabbit breeds: Effects of dose, season and sexual behaviour

Hulot, Françoise; Mariana, J. C.; Cattiau, G.

doi:10.1016/0301-6226(88)90077-2

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…Since a preovulatory peak of LH and ovulation in Experiment 2 was elicited in the GnRH group, ovulation failure in the other treatment groups appears to be due to insufficient stimulation to provoke the LH surge rather than to a lack of mature follicles in the ovaries, as stated by others. 42 Ovarian follicular size at the time of treatment is an important determinant of the ovarian response in induced ovulators and must be taken into account in studies involving ovulatory response. [7][8][9]13,15,17,19,43,44 In this regard, ultrasonography was used in the present study to detect the presence of large follicles in similar numbers among rabbits at the moment of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The number of CL detected per rabbit after the GnRH treatment was similar to that reported in previous studies based on post-mortem or laparotomy examination. 26,42 Ovarian responses following different ovulatory treatments were clearly distinguished using transcutaneous UBM in rabbits. Unlike the effects previously reported in llamas and alpacas, 7,8,13 data from the present study do not support the hypothesis that llama or rabbit seminal plasma, given intramuscularly, induces a preovulatory surge of LH and ovulation in rabbits.…”

Section: Discussionmentioning

confidence: 99%

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In vivo imaging in the rabbit as a model for the study of ovulation-inducing factors

2014

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The study of factors responsible for eliciting ovulation in rabbits has been hampered by the lack of a suitable method of monitoring the ovaries in vivo. Ovarian imaging by ultrasound biomicroscopy was used in two experiments designed to determine the effects of seminal plasma on the ovulatory response in rabbits. In Experiment 1, female rabbits were group-housed and treated intramuscularly with saline, gonadotropin releasing hormone (GnRH), or seminal plasma of llamas or rabbits (n = 4 to 6 per group). Rabbits were euthanized eight days later to evaluate the ovarian response by ultrasound biomicroscopy ex situ. No differences among groups were detected in the proportion of rabbits that ovulated or in the number and size of corpora lutea. The high incidence of ovulation in the negative control group was unexpected, and confounded determination of an ovulation-inducing effect of seminal plasma. In Experiment 2, female rabbits were caged individually, and treated as in Experiment 1 (n = 5 to 7 per group). The ovarian response was evaluated in vivo by transcutaneous ultrasound biomicroscopy. Ovulation and formation of corpora lutea were detected only in rabbits given GnRH. A preovulatory surge in plasma luteinizing hormone concentration and a post-ovulatory rise in plasma progesterone concentration were detected only in rabbits treated with GnRH. Surgical translocation of the ovaries to a subcutaneous position enabled longitudinal assessment of the ovulatory response by ultrasound biomicroscopy. Results clearly documented the effect of physical/social interaction on ovulation in rabbits, and did not support the hypothesis that seminal plasma elicits ovulation in rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivo imaging in the rabbit as a model for the study of ovulation-inducing factors

2014

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“…Only normal morulae were frozen using the procedure derived from Tsunoda et al (1982) and Kojima et al (1985) and described by Garcia-Xim6nez and Vicente (1991 (Bonhoff and Adams, 1985;Hulot et al, 1988 (Hodgson and Pauerstein, 1976). Vicente and Garcfa-Ximdnez (1991) observed that 21% of the total embryos recovered 64-66 h post-coitum were found in the uterus in hCG (251U)-treated does.…”

mentioning

confidence: 99%

Effect of ovarian cystic or haemorrhagic follicles on embryo recovery and survival after transfer in hCG-ovulated rabbits

García-Ximénez¹,

Vicente²

1992

Reprod. Nutr. Dev.

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“…2) using hCG to induce ovulation instead of inducing it by copulation. This hormone is a member of the same structurally similar group of hormones as LH and is widely used for inducing ovulation in rabbits (26)(27)(28)(29)(30)(31). As hCG acts downstream of the CNS, this experimental setting circumvents the CNS-mediated need for copulatory stimulation.…”

Section: Discussionmentioning

confidence: 99%

An experimental test of the ovulatory homolog model of female orgasm

Pavličev

Zupan

Barry

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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The ovulatory homolog model of female orgasm posits that the neuro-endocrine mechanisms underlying female orgasm evolved from and are homologous to the mechanisms mediating copulation-induced ovulation in some mammals. This model predicts that pharmacological agents that affect human orgasm, such as fluoxetine, should also affect ovulation in animals with copulation-induced ovulation, such as rabbits. We tested this prediction by treating rabbits with daily doses of fluoxetine for 2 wk and found that fluoxetine treatment reduces the number of ovulations postcopulation by 30%. In a second experiment we tested whether this result was mediated by an effect on the brain or via peripheral serotonin functions. We treated animals with fluoxetine and induced ovulation with a single injection of human chorionic gonadotropin. In this experiment ovulation rate was nominally reduced by only 8%, which is statistically not significant. We conclude that the effect of fluoxetine on copulation-induced ovulation rate supports the ovulatory homolog model of female orgasm, suggesting that female orgasm has very deep evolutionary roots among the early eutherian mammals.

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HCG-induced ovulation in two rabbit breeds: Effects of dose, season and sexual behaviour

Cited by 13 publications

References 12 publications

In vivo imaging in the rabbit as a model for the study of ovulation-inducing factors

In vivo imaging in the rabbit as a model for the study of ovulation-inducing factors

Effect of ovarian cystic or haemorrhagic follicles on embryo recovery and survival after transfer in hCG-ovulated rabbits

An experimental test of the ovulatory homolog model of female orgasm

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