HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis

Zhang, Lu; Zhou, Xiaolei; Liu, Bowen; Shi, Xu-He; Li, Xianmeng; Xu, Feifei; Fu, Xueli; Wang, Xue; Yang, Kai; Jin, Tianzhi; Sun, Huimin; Li, Qianqian; Zhang, Weiying; Ye, Lihong

doi:10.1016/j.apsb.2022.11.025

Cited by 4 publications

(1 citation statement)

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“…Unlike the ubiquitin-proteasome pathway, HBXIP mainly regulates the acetylation of target proteins by modulating acetylases. For example, tissue chip technology showed that HBXIP expression in tumor cells was related to HOXB13 and STEM20 like kinase1 (MST1) ( 62 , 63 ); further research into the mechanism found that HBXIP can change the acetylation levels of HOXB13 and tumor suppressor proteinMST1 via the acetylase P300 and Histone deacetylase 6 (HDAC6) to regulate chaperone-mediated autophagy HBXIP also recruits protein kinase CβII to stimulate phosphorylation of non-muscle heavy chain myosin IIA, thereby enhancing breast cancer invasion ( 64 ).…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Hepatitis B X-interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post-transcription and post-translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.

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Section: Hbxip and Tumorsmentioning

confidence: 99%