HBx induced upregulation of FATP2 promotes the development of hepatic lipid accumulation

Lu, Yang; Yang, Xiongwen; Kuang, Qin; Wu, Jingjing; Tan, Xueying; Lan, Jianyun; Qiang, Zhe; Feng, Tao

doi:10.1016/j.yexcr.2023.113721

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…In patients with CHB infection, hepatitis B protein X (HBx)-a 17 kDa soluble protein coded by the HBV DNA induces expression of various genes related to lipid accumulation including PPAR [36], SREBP [36], FABP1 [37], LXR [38], and FATP2 [39], thereby promoting lipogenesis. HBx also stimulates various transcription factors, including STAT3, NF-κβ, PI3K/AKT, and Src [40], which promote hepatocyte proliferation [40], inhibit apoptosis [40], and stimulate inflammation [41], thus leading to the development of HCC.…”

Section: Effects Of Chb Infection On the Mafld And Chronic Liver Dise...mentioning

confidence: 99%

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Fernandez,

Alkhalifah,

Afsar

et al. 2024

Pathogens

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Metabolic dysfunction-associated fatty liver disease (MAFLD) has now affected nearly one-third of the global population and has become the number one cause of chronic liver disease in the world because of the obesity pandemic. Chronic hepatitis resulting from hepatitis B virus (HBV) and hepatitis C virus (HCV) remain significant challenges to liver health even in the 21st century. The co-existence of MAFLD and chronic viral hepatitis can markedly alter the disease course of individual diseases and can complicate the management of each of these disorders. A thorough understanding of the pathobiological interactions between MAFLD and these two chronic viral infections is crucial for appropriately managing these patients. In this comprehensive clinical review, we discuss the various mechanisms of chronic viral hepatitis-mediated metabolic dysfunction and the impact of MAFLD on the progression of liver disease.

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Section: Effects Of Chb Infection On the Mafld And Chronic Liver Dise...mentioning

confidence: 99%

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Fernandez,

Alkhalifah,

Afsar

et al. 2024

Pathogens

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“…FATP2/5 are the major isoforms, of which FATP5 is unique in liver [20,21]. Evidence suggested that upregulated FATP2 promoted hepatic fat accumulation and could be one of the potential therapeutic targets for hepatic steatosis [22,23]. In addition, upregulated FATP5 was associated with increased hepatic steatosis in male patients with MAFLD [24].…”

Section: Lipid Metabolism and Mafldmentioning

confidence: 99%

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

Fu,

Wang,

Qin

2024

Metabolites

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Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent liver disease worldwide, affecting approximately two-fifths of the global population. The pathogenesis of MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in the progression of MAFLD, including lipids, carbohydrates, amino acids, and micronutrients. In recent years, the medicinal properties of natural products have attracted widespread attention, and numerous studies have reported their efficacy in ameliorating metabolic disorders and subsequently alleviating MAFLD. This review aims to summarize the metabolic-associated pathological mechanisms of MAFLD, as well as the natural products that regulate metabolic pathways to alleviate MAFLD.

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“…Indeed, increased FATP2 expression contributed to HBx-induced hepatic lipid accumulation, oxidative stress, and inflammation level resulting in the development of primary HCC. However, reduction of FATP2 level significantly prevents HBx from inducing oxidative stress and inflammation [ 41 ].…”

Section: Hbx Role In Hepatocarcinogenesismentioning

confidence: 99%

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates

Agustiningsih,

Rasyak,

Turyadi

et al. 2024

Exploration of Targeted Anti-Tumor Therapy

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Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancers with high mortality rate. Among its various etiological factors, one of the major risk factors for HCC is a chronic infection of hepatitis B virus (HBV). HBV X protein (HBx) has been identified to play an important role in the HBV-induced HCC pathogenesis since it may interfere with several key regulators of many cellular processes. HBx localization within the cells may be beneficial to HBx multiple functions at different phases of HBV infection and associated hepatocarcinogenesis. HBx as a regulatory protein modulates cellular transcription, molecular signal transduction, cell cycle, apoptosis, autophagy, protein degradation pathways, and host genetic stability via interaction with various factors, including its association with various non-coding RNAs. A better understanding on the regulatory mechanism of HBx on various characteristics of HCC would provide an overall picture of HBV-associated HCC. This article addresses recent data on HBx role in the HBV-associated hepatocarcinogenesis.

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HBx induced upregulation of FATP2 promotes the development of hepatic lipid accumulation

Cited by 5 publications

References 49 publications

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates

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