HBV-specific T cell responses in low replicating inactive carrier patients are independent of Hepatitis B surface antigen load

Differential gene expression, irrespective of circulating Hepatitis B Surface Antigen levels, between Inactive Carrier and Nucleos(t)ide Analogue-Treated Hepatitis B Virus patients

“…Interestingly, a previous study on sorted CD4 + and CD8 + T cells from IC patients found the gene expression of TLR-signaling ( MYD88 ), cytotoxicity ( GZMA , GZMK ), and nuclear factor-κB signaling ( BST2 ) to be upregulated in patients with less than 1.5 × 10 3 versus more than 15 × 10 4 IU/mL HBsAg [ 13 ]. These discrepancies might be explained by differences in patient selection, methodology, or cofounding factors—although limited information is available in the study.…”