HBV, mitochondrial stress, and liver fibrosis: chicken or the egg

Guerrieri, Francesca; Levrero, Massimo

doi:10.1097/hep.0000000000000031

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The accumulation of reactive oxygen species and free radicals and the subsequent production of inflammatory cytokines induce the activation and expansion of myofibroblasts. Similarly, viral-hepatitis-related dysregulated T cell responses and mitochondrial stress provide the starting point for myofibroblast activation [28,29]. The activation of myofibroblasts combined with the TGF-β gradient initiated the deposition of collagen in the liver.…”

Section: The Dual Mode Transition Of Myofibroblasts In Fibrotic Liver...mentioning

confidence: 99%

The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis

Yan,

Xie,

Yao

et al. 2023

IJMS

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Hepatic stellate cells (HSCs) are the key promoters of liver fibrosis. In response to liver-fibrosis-inducing factors, HSCs express alpha smooth muscle actin (α-SMA) and obtain myofibroblast phenotype. Collagen secretion and high expression of α-SMA with related high cell tension and migration limitation are the main characteristics of myofibroblasts. How these two characteristics define the role of myofibroblasts in the initiation and progression of liver fibrosis is worth exploring. From this perspective, we explored the correlation between α-SMA expression and collagen secretion in myofibroblasts and the characteristics of collagen deposition in liver fibrosis. Based on a reasonable hypothesis and experimental verification, we believe that the myofibroblast with the α-SMAhighcollagenhigh model do not effectively explain the initial stage and progression characteristics of liver fibrosis. Therefore, we propose a myofibroblast dual-mode transition model in fibrotic liver (DMTM model). In the DMTM model, myofibroblasts have dual modes. Myofibroblasts obtain enhanced α-SMA expression, accompanied by collagen expression inhibition in the high-concentration region of TGF-β. At the edge of the TGF-β positive region, myofibroblasts convert to a high-migration and high-collagen secretion phenotype. This model reasonably explains collagen deposition and expansion in the initial stage of liver fibrosis.

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Section: The Dual Mode Transition Of Myofibroblasts In Fibrotic Liver...mentioning

confidence: 99%

The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis

Yan,

Xie,

Yao

et al. 2023

IJMS

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Targeting mitochondrial quality control: new therapeutic strategies for major diseases

Hong,

Huang,

Zeng

et al. 2024

Military Med Res

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Mitochondria play a crucial role in maintaining the normal physiological state of cells. Hence, ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases. Previous reviews on this topic have however been inconsistencies and lack of systematic organization. Therefore, this review aims to provide a comprehensive and systematic overview of mitochondrial quality control and explore the possibility of targeting the same for the treatment of major diseases. This review systematically summarizes three fundamental characteristics of mitochondrial quality control, including mitochondrial morphology and dynamics, function and metabolism, and protein expression and regulation. It also extensively examines how imbalances in mitochondrial quality are linked to major diseases, such as ischemia-hypoxia, inflammatory disorders, viral infections, metabolic dysregulations, degenerative conditions, and tumors. Additionally, the review explores innovative approaches to target mitochondrial quality control, including using small molecule drugs that regulate critical steps in maintaining mitochondrial quality, nanomolecular materials designed for precise targeting of mitochondria, and novel cellular therapies, such as vesicle therapy and mitochondrial transplantation. This review offers a novel perspective on comprehending the shared mechanisms underlying the occurrence and progression of major diseases and provides theoretical support and practical guidance for the clinical implementation of innovative therapeutic strategies that target mitochondrial quality control for treating major diseases.

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HBV, mitochondrial stress, and liver fibrosis: chicken or the egg

Cited by 2 publications

References 9 publications

The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis

The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis

Targeting mitochondrial quality control: new therapeutic strategies for major diseases

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