HBV, HCV and HIV seroprevalence among blood donors in Istanbul, Turkey: how effective are the changes in the national blood transfusion policies?

Acar, Ali; Kemahlı, Sabri; Altunay, Hüsnü; Kosan, Erdogan; Oncul, Oral; Görenek, Levent; Çavuşlu, Şaban

doi:10.1016/s1413-8670(10)70009-x

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…An important disadvantage of anti-HCV assay is that the rate of false-positive results is high especially at low anti-HCV value (8,14,15). According to the CDC guidelines, if anti-HCV results are low S/Co, a supplemental test is required (16).…”

Section: Discussionmentioning

confidence: 99%

The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

Demircili¹,

Özdemir²,

Feyzioğlu³

et al. 2016

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Section: Discussionmentioning

confidence: 99%

The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

Demircili¹,

Özdemir²,

Feyzioğlu³

et al. 2016

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“…12 It has also been estimated that on applying the confirmatory test to grey zone samples resulted up to only 2% of true positivity. 13 The study found a total of 144 (0.58%) samples in grey zone area for all three viral markers as compared to 0.14-0.29% found by other authors. 13,14 This may be due the differences in the type of ELISA kits used for performing the test.…”

Section: Discussionmentioning

confidence: 56%

“…13 The study found a total of 144 (0.58%) samples in grey zone area for all three viral markers as compared to 0.14-0.29% found by other authors. 13,14 This may be due the differences in the type of ELISA kits used for performing the test. We detected 24.30% of 144 grey zone samples showing repeat reactivity, for either of the viral markers, on repeat testing as that of 4.6-75% in relevant studies.…”

Section: Discussionmentioning

confidence: 56%

“…We detected 24.30% of 144 grey zone samples showing repeat reactivity, for either of the viral markers, on repeat testing as that of 4.6-75% in relevant studies. [13][14][15] One of limitations of this study is we could not be able to subject the grey zone samples for confirmatory assay. Hence, we are not able to comment on the overall effectiveness of repeat grey zone sample testing in improving the transfusion safety.…”

Section: Discussionmentioning

confidence: 99%

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Effect of grey zone sample testing of transfusion transmissible infectious diseases on safety of blood-experience of a tertiary care referral teaching hospital blood bank from South India

Anitha¹,

Babu

Praveen

et al. 2017

Int J Res Med Sci

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Background: Grey zone samples with optical density (OD) lying between cut-off OD and 10% below the cut-off OD (cut-off OD × 0.9) were identified during routine transfusion transmissible infectious disease (TTIs) screening. Enzyme-linked immunosorbent assay (ELISA) used for this purpose can sometimes fail to detect blood donors who are recently infected or possessing the low viremia. Estimation of a grey zone in ELISA testing and repeat testing of grey zone samples can further help in reducing the risks of TTI in countries where nucleic acid amplification testing for TTIs is not feasible.Methods: On performing repeat ELISA testing on grey zone samples in duplicate, the samples showing both OD values below grey zone were marked nonreactive, and samples showing one or both OD value in the grey zone were marked indeterminate. The samples on repeat testing showing one or both OD above cut-off value were labelled reactive.Results: Of the 21,908 blood donors screened during the study period, a total of 144 blood donors were found to be in grey zone. On repeat testing of these grey zone samples, 35 (24.30%) were found to be reactive for TTIs.Conclusions: Estimation of grey zone samples with repeat testing can further enhance the safety of blood transfusion in resource poor developing nations where more sophisticated and sensitive methods such as nucleic acid amplification test (NAT) is not available in all the blood banks.

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“…(20) . Ülkemizde donör taramalarında HIV sıklığı yapılan çalışma-larda % 0.0025, % 0.008 olarak bildirilmiş (1,3) . Sık transfüzyon alan hematoloji onkoloji hastalarında yapılan birçok çalışmada anti-HIV pozitifliğine rastlanmamıştır (9,13,19) .…”

Section: Discussionunclassified

Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion

Şahin¹,

Yıldırmak²,

Bulut³

2018

Ankem Derg

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ÖZET Talasemi majörlü hastalar yaşamları boyunca çok sayıda kan transfüzyonuna ihtiyaç duyarlar bu nedenle transfüzyonla bulaşan hastalıklar açısından risk altındadırlar. Bu çalışma, çocuk hematoloji kliniğimizde takip edilen talasemi majörlü hastalarda transfüzyon ile bulaşan hepatit B (HBV), hepatit C (HCV) ve insan immün yetmezlik virüsü (HIV) infeksiyonlarının SUMMARY Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion Thalassemia major patients need many blood transfusions throughout their lives. Hence, they are at risk for transfusion-transmitted diseases. This study was conducted to determine the frequency of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV) infections in thalassemia major patients in our pediatric hematology clinic and to investigate the clinical and demographic characteristics of positive patients.In

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HBV, HCV and HIV seroprevalence among blood donors in Istanbul, Turkey: how effective are the changes in the national blood transfusion policies?

Cited by 22 publications

References 11 publications

The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

Effect of grey zone sample testing of transfusion transmissible infectious diseases on safety of blood-experience of a tertiary care referral teaching hospital blood bank from South India

Frequency of Hepatitis B, Hepatitis C and HIV (Human Immunodeficiency Virus) in Thalassemia Major Patients Having Multiple Transfusion

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