HBV epidemiology in Latin America

Paraná, Raymundo; Almeida, D.

doi:10.1016/s1386-6532(05)80022-8

Cited by 43 publications

(26 citation statements)

References 22 publications

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“…In accordance with previous reports (Moraes et al 1996, Araujo et al 2004, Ribeiro et al 2006, Mello et al 2007, Tonetto et al 2009), this study showed that HBV genotype A was the most prevalent in RJ, followed by genotypes D and F. The predominance of genotype A may be the result of the influx of African population during the slavery colonial period and the influence from European immigration that occurred during the 20th century. An interesting finding was that HBV genotype F infection, derived from the Amerindian population and the most prevalent in Central and South America, was rare in Brazil, suggesting that indigenous population had less influence in the introduction of HBV in our country (Parana & Almeida 2005, Viana et al 2005, Mello et al 2007.…”

Section: Discussionmentioning

confidence: 84%

Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features

Nabuco

Mello

Gomes

et al. 2012

Mem. Inst. Oswaldo Cruz

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Data concerning the relationship between hepatitis B virus (HBV) genotypes and liver histology are scarce. The aim of this study was to compare HBV non-B and non-C genotypes according to demographic features, clinical status, HBV-DNA levels and liver histology in Rio de Janeiro. One hundred twenty one consecutive chronic HBV-infected patients were enrolled during two-year period and data were prospectively collected. Sera were tested for HBV genotyping using restriction fragment length polymorphism. Liver biopsy was obtained from patients with either increased alanine aminotransferase (ALT) or HBV-DNA levels. Genotype A was the most common, found in 82 (68%) patients, followed by F in 19 (15%), D in 17 (14%), B in one (1%) and C in two (2%). There was no association between HBV genotypes A, D and F and gender (p = 0.37), age (p = 0.78), race (p = 0.22), mode of infection (p = 0.94), HB "e" antigen status (p = 0.37) and HBV-DNA levels (p = 0.47). The ALT levels were lower in genotype D (75%) compared with A (47%) and F (55%) (p = 0.05). Liver biopsy showed lower inflammation [histological activity index (HAI) = 4] and fibrosis (F) (= 0) scores in genotype D than in genotypes A (HAI = 5, p < 0.001; F = 2, p = 0.008) or F (HAI = 5, p = 0.009; F = 2, p = 0.01). Genotype A was the most prevalent in chronic HBV-infected patients and genotype D patients presented with less intense liver disease

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Section: Discussionmentioning

confidence: 84%

Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features

Nabuco

Mello

Gomes

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…The Amazon is one of the regions with a high prevalence of diseases associated with HBV infection. [2][3][4] Since the early 1960s, outbreaks of fulminant hepatitis associated with hepatitis D virus (HDV) superinfection of an HBsAg carrier, known as "Lá brea Black Fever," 5 have been reported from rural communities of the region.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAgpositive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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“…7,8 Na América Latina, a hepatite B é considerada endêmica e estima-se que 400 mil casos novos da doença ocorram a cada ano. 9,10 O aumento na prevalência da doença ocorre a partir dos 16 anos de idade, sugerindo a transmissão sexual como a principal via de infecção. 11 Os registros de doenças transmissíveis são influenciados por características da doença, que incluem tanto os mecanismos de transmissão como a capacidade dos serviços de saúde em captar os casos.…”

Section: Introductionunclassified

Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

Costa¹,

Paula²,

Ignotti³

2012

Epidemiol. Serv. Saúde

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HBV epidemiology in Latin America

Cited by 43 publications

References 22 publications

Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features

Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Detecção de infecção pelo vírus da hepatite B nos municípios brasileiros segundo cobertura dos serviços de hemoterapia, no período de 2001 a 2008

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