HBV Core Protein Enhances Cytokine Production

Wu, Shuang; Sasaki, Reina; Nakamura, Masato; Haga, Yuki; Jiang, Xia; Nakamoto, Shingo; Yokosuka, Osamu

doi:10.3390/diseases3030213

Cited by 12 publications

(14 citation statements)

References 32 publications

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“…The HBV core protein enhances cytokine production [155], and HBeAg is reportedly associated with the host immune response and cytokine production [156,157,158], both of which play roles in HBV-associated HCC.…”

Section: Molecular Mechanisms Of Hbv-associated Hccmentioning

confidence: 99%

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

Kanda

Goto

Hirotsu

et al. 2019

IJMS

Self Cite

209

145

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Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC despite recent progress in the efficacy of anticancer drugs for advanced stages of HCC. Here, we review recent knowledge concerning the molecular mechanisms of liver cirrhosis and its progression to HCC from genetic and epigenomic points of view. Because ~70% of patients with HCC have hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection, we focused on HBV- and HCV-associated HCC. The literature suggests that genetic and epigenetic factors, such as microRNAs, play a role in liver cirrhosis and its progression to HCC, and that HBV- and HCV-encoded proteins appear to be involved in hepatocarcinogenesis. Further studies are needed to elucidate the mechanisms, including immune checkpoints and molecular targets of kinase inhibitors, associated with liver cirrhosis and its progression to HCC.

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Section: Molecular Mechanisms Of Hbv-associated Hccmentioning

confidence: 99%

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

Kanda

Goto

Hirotsu

et al. 2019

IJMS

Self Cite

209

145

View full text Add to dashboard Cite

show abstract

“…Recent studies provided additional evidence of the pivotal role of inflammation in patients with chronic HBV infection, which may result in cirrhosis following secondary necroinflammation with the eventual progression to HCC 17,18 . Pro-inflammatory mediators, such as interferons and cytokines, are produced after the binding of the HBV core protein to membrane heparin sulfate exposed on the cell surface of human hepatoma cells 19,20 . Interleukin-37 (IL-37), a member of the IL-1 family, is an anti-inflammatory cytokine produced by immune cells and suppresses the production of inflammatory cytokines in several types of disease.…”

Section: Introductionmentioning

confidence: 99%

Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population

Al-Anazi

Matou‐Nasri

Al-Qahtani

et al. 2019

Sci Rep

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Interleukin-37 (IL-37) has recently been recognized as a strong anti-inflammatory cytokine having anti-tumor activity against hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients. HCC is a typical inflammation-related cancer, and genetic variations within the IL-37 gene may be associated with the risk of HBV infection. Identification of the allelic patterns that genetically have a high disease risk is essential for the development of preventive diagnostics for HBV-mediated liver disease pathogenesis. In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within the IL-37 gene and disease sequelae associated with HBV infection. We genotyped ten IL-37 SNPs in 1274 patients infected with HBV and 599 healthy controls from a Saudi Arabian population. Among the selected SNPs, two SNPs (rs2723175 and rs2708973) were strongly associated with HBV infection, and six SNPs (rs2723176, rs2723175, rs2723186, rs364030, rs28947200, rs4392270) were associated with HBV clearance, comparing healthy controls and HBV infected-patients respectively. A suggestive association of rs4849133 was identified with active HBV surface antigen (HBsAg) carrier and HBV-related liver disease progression. In conclusion, our findings suggest that variations at the IL-37 gene may be useful as genetic predictive risk factors for HBV infection and HBV-mediated liver disease progression in the Saudi Arabian population.

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“…The pathogenetic mechanisms underlying HBV carcinogenesis appear complex and the following processes have been demonstrated in playing a role: HBV genome integration, chronic inflammation, epigenetic mechanisms, host immune response and cytokine production promoted by the HBV core protein. 44 HBV infection is also reported in thalassemia patients. Worldwide, 0.3%-5.7% of thalassemia patients are hepatitis B surface antigen (HBsAg)-positive.…”

Section: The Role Of Hbv Infectionmentioning

confidence: 96%

<p>Thalassemia and hepatocellular carcinoma: links and risks</p>

Marsella

Ricchi²

2019

JBM

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The increased survival and lifespan of thalassemia patients, in the setting of better iron overload monitoring and chelation, have also however increased the incidence of diseases and complications, which were less likely to develop. Among these, one of the most worrying in recent years is hepatocellular carcinoma (HCC). Due to blood transfusions, many patients with thalassemia are or have been infected with hepatitis C virus (HCV) or hepatitis B virus (HBV), especially those born before the 1990s or in countries in which universal HBV vaccination and safe blood programs are still not completely implemented. However, HCC has also been described in nontransfused patients and in those who are HCVand HBV-negative. Therefore, other risk factors are involved in hepatocarcinogenesis in thalassemia. The following review analyzes recent literature on the role of different risk factors in the progression of liver disease in thalassemia as well as the importance of surveillance. Treatment of HCC in thalassemia is still highly debated and requires further studies.

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HBV Core Protein Enhances Cytokine Production

Cited by 12 publications

References 32 publications

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review

Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population

<p>Thalassemia and hepatocellular carcinoma: links and risks</p>

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