“…In cancer cells, ectopic overexpression of HBP1 can result in growth arrest, apoptosis, or differentiation, suggesting HBP1's possible role in tumor suppression (Chen et al, ; Kim et al, ; Lee et al, ; Yao, Works, Romagnoli, & Austin, ). Meanwhile, HBP1 also plays a crucial role in tissue differentiation, including muscle (Shih et al, ), myeloid (Yao et al, ), skin (Borrelli et al, ), and nervous cells (Watanabe, Kageyama, & Ohtsuka, ). Elevated HBP1 expression has been shown to determine the differentiation timing of erythroid, megakaryocyte and keratinocyte, and cortical neurogenesis (Borrelli et al, ; Watanabe et al, ).…”