HBEGF Induced XBP1s Expression, a Novel Form of Unfolded Protein Response

Abstract

DM prognostication, and remained statistically significant after multivariable adjustment. RS had improved predictive value for DMFS in the HPV-negative subgroup (HR 20.8; 95% CI, 2.6-166, P Z 0.004). Conclusion: We have identified and validated a group of genes that predict distant metastasis among loco-regionally advanced HNSCC tumors. This score offers a prognostic tool for detecting a group of HNSCC patients at high risk for DM who may benefit from intensified monitoring and/or treatment.