“…The lower CID 50 observed in the study by Komiya and colleagues 55 may be the result of using blood collected during the early stages of acute infection before the detection of anti‐HBc and anti‐HBs, which may have nullified any tendency for neutralization of the inocula. A lack of detection of these antibodies in the blood, however, does not necessarily equate with an absence of secretion 14 since complexing with specific antigen was not investigated. Unfortunately, neither of these studies used seronegative occult infectious samples of blood that were HBV DNA–positive but HBsAg and anti‐HBc–negative or blood from more conventionally defined occult hepatitis B cases that were HBsAg and anti‐HBs–negative, but HBV DNA and anti‐HBc–positive to define minimum infectious doses of HBV.…”