HbA1c, estandarización y expresión de resultados

Álvarez-García, Elías

doi:10.1016/j.endonu.2010.02.010

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…In the measurements made at the end of treatment (Table 1), there was no reduction in glucose level in the groups that received E. carlinae . The glycohemoglobin (HbA1) is a general term used to describe hemoglobin that has been modified by the addition of glucose through a nonenzymatic mechanism, and the HbA1c is one of those glycosides compounds in particular that reflects average blood glucose in patient 2 or 3 months before blood collection [16, 17]. According to the United Kingdom Prospective Diabetes Study (UKPDS), each 1% reduction in glycosylated hemoglobin (HbA1c) was associated with a 37% reduction in microvascular complications, 18% fewer myocardial infarction, and 21% fewer diabetes-related deaths [15].…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

Noriega‐Cisneros

Ortiz‐Avila

Esquivel‐Gutiérrez

et al. 2012

Biochemistry Research International

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Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract of Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin- (STZ-) induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment with E. carlinae prevented these changes. The administration of E. carlinae extract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus administration of E. carlinae is able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

Noriega‐Cisneros

Ortiz‐Avila

Esquivel‐Gutiérrez

et al. 2012

Biochemistry Research International

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“…Glycosylated haemoglobin is one of those glycosides compounds in particular that reflects average blood glucose in patients 2~3 months before blood collection [20]. The results obtained from the measurement of HbA1c show a clear deference between untreated diabetic (10%) and Po-diabetic groups (6%).…”

Section: Levels Of Glycemia Insulinemia and Glycosylated Hemoglobinmentioning

confidence: 96%

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Guenzet¹,

Krouf²,

Berzou³

2017

JPP

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Abstract:The aim of this study was to investigate the antihyperglycemic and antioxidant effects of Po (Portulaca oleracea) lyophilised aqueous extract in diabetic male Wistar rats. Diabetes was induced intraperitonially by a single injection of STZ (streptozotocin) (60 mg/kg bw (body weight)). Twenty diabetic rats, weighing 263 ± 5 g, were divided into two groups fed a casein diet supplemented or not with Po extract (1 g/kg bw), for four weeks. Control group (n = 6) received 0.23~0.25 mL of citrate buffer and was fed a standard diet during the experiment. The study was carried out at Oran University, Algeria and the entire experiments lasted from September 2011 to July 2012. Blood was obtained from the abdominal aorta of rats after fasting overnight and standard methods were used for the extraction of spices, determination of glycemia, insulinemia, lipid peroxidation and antioxidant enzymes activities. Portulaca oleracea treated compared to untreated rats, glycemia and HbA1c values were respectively 2.8-and 1.7-fold lower. TBARS (thiobarbituric acid reactive substances) concentrations were reduced in RBC (red blood cells) (−54%) and plasma (−65%). Moreover, in liver and kidney, TBARS values were respectively 1.8-and 2-fold lower. SOD (superoxide dismutase) and GSH-Px (glutathione peroxidase) activities were increased respectively by +38% and +85%, in liver. GSSG-Red (glutathione reductase) activity was 1.9-fold higher in kidney, while CAT (catalase) was improved in kidney (+48%). In RBCs, SOD, GSH-Px, GSSH-Red and CAT activities were increased by 31%, 42%, 56% and +50%, respectively. These data have cast a new light on the actions of Portulaca oleracea and its antioxidant potential benefits in preventing diabetes and its complications.

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“…23 Our results and other recent publications in different countries have recognized severe problems in this regard and their comments are in opposition to the statement of a completed globalization in HbA1c measurement. [24][25][26] Again, our evaluation, based on an experimental model of daily clinical practice, in an adequate sample size, has shown a critical issue concerning diabetes management by different statistical methods; a very poor concordance or agreement in HbA1c results was found in more than half of the participating laboratories. The robust clinical significance of our results would not change with involvement of more clinical laboratories or subjects.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin AIc: A reliable and accurate test for diabetes care? A prospective study in Mexico

González-González¹,

Rodríguez-Gutiérrez²,

Lavalle-González³

et al. 2013

Salud Publica Mex

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Objective. To compare the concordance correlation coefficient for HbAlc results in an in-field experience. Materials and methods. A prospective study in Monterrey, Mexico from April to August 2012 was conducted to evaluate the day-to-day clinical situation when measuring HbAlc. Blood samples from 38 consecutive patients were sent to seven local laboratories and one international reference laboratory. Results. Poor concordance was found in 4 out of 7 laboratories, moderate in 2 out of 7, and significant in just one. HbAlc values from three laboratories fluctuated more than 1% above or below the reference laboratory in more than 30% of cases, and more than 2% in 10%-20% of subjects. Conclusions. Standardized HbAlc measurement has not occurred worldwide. Physicians should be aware of this issue and be cautious of HbAlc guidelines on diabetes diagnosis or management until proper standardization programs are implemented.

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HbA1c, estandarización y expresión de resultados

Cited by 10 publications

References 19 publications

Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Hemoglobin AIc: A reliable and accurate test for diabetes care? A prospective study in Mexico

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