HBA1c and 2 Hours Post-Prandial Blood Sugar Levels in Known Cirrhotic Adult Patients due to HBsAg and/or Anti-HCV Positive, Who are Not Known Diabetics

Abstract

Background: Liver has a special and unique system of glucose metabolism which keeps its levels under normal ranges. In chronic liver hepatitis and cirrhosis this mechanism is altered. Aim: To evaluate undiagnosed diabetics through HbA1C and 2 hours post prandial blood sugar levels in confirmed hepatitis B and C cirrhotic adult patients. Study design: Descriptive cross-sectional study Place and duration of study: Department of Gastroenterology, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana from 1st July 2020 to 30th June 2021. Methodology: One hundred and twenty four patients >50 years with liver cirrhosis due to hepatitis B and C were enrolled. All clinical, demographic data of patients as well as their blood analysis was performed for testing HbA1C and two hour post prandial blood sugar (as well as liver function test). Results: The mean age was 57.9±5.9 years and majority of patients were males in both hepatitis cases. There were 39.5% of liver cirrhosis patients having undiagnosed diabetes which was confirmed by 2 hours post prandial blood sugar and HbA1c. Within this value 54.8% had hepatitis C and 24.2% had hepatitis B. Conclusion: There is a high prevalence of elevated HbA1c, post prandial blood sugar and consequently diabetic population (undiagnosed) among hepatitis B and C liver cirrhotic adult patients. Keywords: Post-prandial blood sugar, Cirrhotic adult patients, HBsAg, Anti-HCV, Diabetics