Hb Bakersfield (<i>HBA1</i>: c.151_152insGGAGCC): The Insertion of Arg-His Between Codons 49 and 50 of the α1-Globin Chain Leads to Increased Oxygen Affinity

Brunner-Agten, Saskia; Känel, Thomas von; Röthlisberger, Benno; Broquet, Charles; Huber, Andreas

doi:10.1080/03630269.2017.1302467

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…In addition, it was found that higher MCV was associated with an elevated oxygen pressure ( 27 ) and an increased oxygen affinity in red blood cells ( 28 ). Then higher MCV could result in enhanced oxygen saturation in red blood cells.…”

Section: Discussionmentioning

confidence: 99%

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Liu

Yang

et al. 2021

Front. Oncol.

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ObjectiveTo elucidate the prognostic significance of mean corpuscular volume (MCV), with implications of habitual alcohol intake in stage II-III colorectal cancer (CRC).BackgroundMCV had the potential to become an ideal prognostic biomarker and be put into clinical application. Few studies, however, have explored whether habitual alcohol intake which greatly increased the value of MCV would affect the prognostic role of MCV.MethodsEligible patients were identified from the CRC database of Fudan University Shanghai Cancer Center (FUSCC) between January 2012 and December 2013. Survival analyses were constructed using the Kaplan–Meier method to evaluate the survival time distribution, and the log-rank test was used to determine the survival differences. Univariate and multivariate Cox proportional hazard models were built to calculate the hazard ratios of different prognostic factors.ResultsA total of 694 patients diagnosed with stage II-III CRC between January 2012 and December 2013 were identified from FUSCC. Low pretreatment MCV was independently associated with 72.0% increased risk of overall mortality compared with normal MCV (HR = 1.720, 95%CI =1.028-2.876, P =0.039, using normal MCV as the reference). In patients with habitual alcohol intake, however, pretreatment MCV positively correlated with the mortality (P = 0.02) and tumor recurrence (P = 0.002) after adjusting for other known prognostic factors.ConclusionsIn CRC patients without habitual alcohol intake, low (<80 fL) level of pretreatment MCV was a predictor of poor prognosis. In patients with habitual alcohol intake, however, pretreatment MCV showed the opposite prognostic role, which would elicit many fundamental studies to elucidate the mechanisms behind.

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Section: Discussionmentioning

confidence: 99%

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Liu

Yang

et al. 2021

Front. Oncol.

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“…Fewer RBCs will result in less oxygen available to the tumor, which will increase the proportion of hypoxic tumor cells. Hypoxia reduces the sensitivity of cells to radiation therapy, leading to a poor prognosis (21,(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of mean corpuscular volume as a prognostic indicator of radiotherapy for locally advanced lung cancer: a retrospective cohort study

Wang¹,

Zhang²

2022

J Thorac Dis

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Background: Although the prognosis of solid tumors is related to the mean corpuscular volume (MCV), which can roughly predict the prognosis of patients, its correlation with locally advanced lung cancer is still unclear. We evaluated the relationship between serum MCV levels and prognosis in patients before radiotherapy.Methods: We retrospectively collected the age, sex, smoking history, TNM stage, ECOG score, hematocrit (HCT), MCV, mean corpuscular hemoglobin (MCH), and red blood cell distribution width-standard deviation (RDW-SD) of patients with locally advanced lung cancer who received chest radiotherapy from 2013 to 2017, and analyzed the relationship between this information and the overall survival (OS).Results: Among all patients, 89 were male (79.5%), 23 were female (20.5%), 46 (41.1%) were older than 65 years, and 66 (58.9%) were younger than 65 years. Seventy-four patients had MCV <93.65 fL, 38 patients had MCV ≥93.65 fL, and the median follow-up period was 24 months. The patients with high T stage, high N stage, and high MCV had lower OS (P<0.05). In the Cox regression analysis, MCV [odds ratio (OR) =0.534, 95% confidence interval (CI): 0.349-0.818, P=0.01], T stage (OR =0.654, 95% CI: 0.440-0.972, P=0.04) and N stage (OR =0.545, 95% CI: 0.371-0.801, P=0.01) were predictors of prognosis. Conclusions:In the clinical treatment of patients with locally advanced lung cancer, MCV can be used to roughly predict their survival time.

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“…There was a significant correlation between MCV and several oxygen parameters [ 11 ]. Higher MCV are associated with an elevated oxygen pressure [ 11 ] and an increased oxygen affinity in red blood cells [ 12 ]. And then higher MCV leads to enhanced oxygen saturation in red blood cells.…”

Section: Discussionmentioning

confidence: 99%

Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer

Zhang

Chen

et al. 2018

Gastroenterology Research and Practice

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Background The aim of this study was to identify if blood routine parameters and serum tumor marker are potential predictive factors for tumor response to preoperative chemoradiotherapy (CRT) in locally advanced rectal cancer. Materials and Methods 55 locally advanced rectal cancer patients were treated with preoperative CRT in this study. The total dose of preoperative radiotherapy was 45 Gy in 25 fractions of 1.8 in 5 weeks. All patients concurrently received 825 mg/m2 capecitabine orally twice daily on days 1 to 14 and 22 to 35. Total mesorectal excision (TME) was performed 6 weeks after the end of preoperative CRT. Blood routine examination and serum tumor marker were checked before preoperative CRT. Tumor response to preoperative CRT was evaluated with the semiquantitative tumor regression grading (TRG) system proposed by Dworak criteria according to histopathological examination of the surgical specimens. Univariable and multivariable logistic regression analyses were used to test the association between blood routine parameters and serum tumor marker and tumor response to preoperative CRT. Results Univariate logistic regression analysis revealed that differentiation, lymphocyte, LMR, MCV, PLR, and CEA have been significantly associated with tumor response to preoperative CRT. Multivariate logistic regression analysis revealed that differentiation, MCV, and CEA were the predictors of tumor response to preoperative CRT. According to the ROC analysis, the AUC of differentiation, MCV, and CEA was 0.794, 0.802, and 0.723, respectively. Optimal cutoff points for MCV and CEA were 87.65 fl and 4.05 ng/ml, respectively. Conclusion MCV is a potential predictive factor for tumor response to preoperative chemoradiation in locally advanced rectal cancer.

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Hb Bakersfield (HBA1: c.151_152insGGAGCC): The Insertion of Arg-His Between Codons 49 and 50 of the α1-Globin Chain Leads to Increased Oxygen Affinity

Cited by 5 publications

References 17 publications

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Clinical significance of mean corpuscular volume as a prognostic indicator of radiotherapy for locally advanced lung cancer: a retrospective cohort study

Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer

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