HB-50: A Pre-Clinical Study of a Prophylactic for Wound Infection

Harris, Scott M.; Zhang, Lijuan; Parente, Jody; Rodeheaver, George T.; Falla, Timothy J.

doi:10.1007/978-0-387-26575-9_118

Understanding Biology Using Peptides

DOI: 10.1007/978-0-387-26575-9_118

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HB-50: A Pre-Clinical Study of a Prophylactic for Wound Infection

Scott M. Harris¹,

Lijuan Zhang²,

Jody Parente³

et al.

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Cited by 2 publications

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A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

García,

Fuentes,

Alonso

et al. 2024

J. Nat. Prod.

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Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin secretions have unveiled remarkable structural diversity and a wide range of activities. This study explores the potential of these peptides for drug development by examining granted patents, amino acid modifications related to patented peptides, and recent amphibians' taxonomic updates influencing AMP names. A total of 188 granted patents related to different anuran peptides were found, with Asia and North America being the predominant regions, contributing 65.4% and 15.4%, respectively. Conversely, although the Neotropical region is the world's most diversified region for amphibians, it holds only 3.7% of the identified patents. The antimicrobial activities of the peptides are claimed in 118 of these 188 patents. Additionally, for 160 of these peptides, 66 patents were registered for the natural sequence, 69 for both natural and derivative sequences, and 20 exclusively for sequence derivatives. Notably, common modifications include alterations in the side chains of amino acids and modifications to the peptides' N-and C-termini. This review underscores the biomedical potential of anuran-derived AMPs, emphasizing the need to bridge the gap between AMP description and practical drug development while highlighting the urgency of biodiversity conservation to facilitate biomedical discoveries.

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A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

García,

Fuentes,

Alonso

et al. 2024

J. Nat. Prod.

View full text Add to dashboard Cite

show abstract

A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides

Browne

Chakraborty

Chen

et al. 2020

IJMS

295

241

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Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health. The traditional antibiotic pipeline has been exhausted, prompting research into alternate antimicrobial strategies. Inspired by nature, antimicrobial peptides are rapidly gaining attention for their clinical potential as they present distinct advantages over traditional antibiotics. Antimicrobial peptides are found in all forms of life and demonstrate a pivotal role in the innate immune system. Many antimicrobial peptides are evolutionarily conserved, with limited propensity for resistance. Additionally, chemical modifications to the peptide backbone can be used to improve biological activity and stability and reduce toxicity. This review details the therapeutic potential of peptide-based antimicrobials, as well as the challenges needed to overcome in order for clinical translation. We explore the proposed mechanisms of activity, design of synthetic biomimics, and how this novel class of antimicrobial compound may address the need for effective antibiotics. Finally, we discuss commercially available peptide-based antimicrobials and antimicrobial peptides in clinical trials.

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HB-50: A Pre-Clinical Study of a Prophylactic for Wound Infection

Cited by 2 publications

References 3 publications

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides

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