Hazards of Recurrence, Second Primary, or Other Tumor at Ten Years After Surgery for Non–Small-Cell Lung Cancer

Fink-Neuboeck, Nicole; Lindenmann, Joerg; Porubsky, Christian; Fediuk, Melanie; Anegg, Udo; Maier, Andrea B.; Smolle, Josef; Lamont, Eugenia; Smolle‐Jüttner, Freyja‐Maria

doi:10.1016/j.cllc.2020.02.011

Cited by 17 publications

(25 citation statements)

References 26 publications

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“…As a result of tobacco exposure, survivors of lung cancer have an increased risk for smoking-related comorbidities, including chronic obstructive pulmonary disease and cardiovascular disease [15]. Survivors who are current and former smokers are at risk for developing a second lung cancer and other smoking-related cancers, particularly in the head and neck and urinary tract [16].…”

Section: Introductionmentioning

confidence: 99%

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

et al. 2021

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Survivors of lung and colorectal cancer have high post-treatment needs; the majority are older and suffer from greater comorbidities and poor quality of life (QOL). They remain underrepresented in research, leading to significant disparities in post-treatment outcomes. Personalized post-treatment follow-up care and care coordination among healthcare teams is a priority for survivors of lung and colorectal cancer. However, there are few evidence-based interventions that address survivors’ post-treatment needs beyond the use of a follow-up care plan. This paper describes the rationale and design of an evidence-informed telehealth intervention that integrates shared care coordination between oncology/primary care and self-management skills building to empower post-treatment survivors of lung and colorectal cancer. The intervention design was informed by (1) contemporary published evidence on cancer survivorship, (2) our previous research in lung and colorectal cancer survivorship, (3) the chronic care self-management model (CCM), and (4) shared post-treatment follow-up care between oncology and primary care. A two-arm, parallel randomized controlled trial will determine the efficacy of the telehealth intervention to improve cancer care delivery and survivor-specific outcomes. ClinicalTrials.govIdentifier: NCT04428905

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Section: Introductionmentioning

confidence: 99%

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

et al. 2021

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“…In this context, reliable risk analysis of postoperative tumor recurrence seemed to be mandatory for early detection of treatable recurrence, even after esophagectomy for EC. Estimation of HR for postoperative tumor recurrence was already reported for resected colon cancer, breast cancer, and lung cancer [20][21][22], but not for EC, up till now. To our best knowledge the present analysis was the first study dealing with the risk analysis of postoperative tumor recurrence in case of resected EC.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, reliable risk estimates of tumor recurrence are of pivotal importance to establish optimal postoperative surveillance strategies, as proposed in case of resected colon cancer, breast cancer, and lung cancer, respectively [20][21][22]. It was shown that the implementation of risk estimates of tumor recurrence is important for the detection of treatable recurrence.…”

Section: Introductionmentioning

confidence: 99%

Hazard Curves for Tumor Recurrence and Tumor-Related Death Following Esophagectomy for Esophageal Cancer

Lindenmann

Fediuk

Fink-Neuboeck

et al. 2020

Cancers

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Background: The knowledge of both patterns and risk of relapse following resection for esophageal cancer is crucial for establishing appropriate surveillance schedules. The aim of this study was to evaluate the pattern of hazards for tumor recurrence and tumor-related death in the postoperative long-term follow-up after esophagectomy. Methods: Retrospective single-center analysis of 362 patients, with resected esophageal cancer. Multivariate Cox proportional hazard model was used. Results: A total of 192 (53%) had postoperative tumor recurrence. The relapse patterns of adenocarcinoma and squamous-cell carcinoma showed that each had a single peak, 12 months after surgery. After induction there was one peak at 5 months, the non-induced patients peaked 11 months, postoperatively. At 18 months, the recurrence hazard declined sharply in all cases. The hazard curves for tumor-related death were bimodal for adenocarcinoma, with two peaks at 6 and 22 months and one single peak for squamous-cell carcinoma at 18 months after surgery, showing pronounced decline later on. Conclusion: In curatively resected esophageal cancer, both tumor recurrence hazard and hazard for tumor-related death showed distinct, partly bimodal patterns. It could be justified to intensify the surveillance during the first two postoperative years by initiating a close-meshed follow-up to detect and treat tumor recurrence, as early as possible.

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“…Lung cancer is the leading cause of cancer-related death with NSCLC accounting for~90% of new cases (21). Even when curative surgery is performed, 30-50% of NSCLC patients develop locoregional or distant recurrence (22,23). Melanoma can recur in 50% of the patients (20) sometimes a decade or more following removal of the primary tumor (24).…”

Section: Introductionmentioning

confidence: 99%

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

Sauer¹,

Reed

Ihnat

et al. 2021

Front. Oncol.

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Cancer recurrence remains a great fear for many cancer survivors following their initial, apparently successful, therapy. Despite significant improvement in the overall survival of many types of cancer, metastasis accounts for ~90% of all cancer mortality. There is a growing understanding that future therapeutic practices must accommodate this unmet medical need in preventing metastatic recurrence. Accumulating evidence supports dormant disseminated tumor cells (DTCs) as a source of cancer recurrence and recognizes the need for novel strategies to target these tumor cells. This review presents strategies to target dormant quiescent DTCs that reside at secondary sites. These strategies aim to prevent recurrence by maintaining dormant DTCs at bay, or eradicating them. Various approaches are presented, including: reinforcing the niche where dormant DTCs reside in order to keep dormant DTCs at bay; promoting cell intrinsic mechanisms to induce dormancy; preventing the engagement of dormant DTCs with their supportive niche in order to prevent their reactivation; targeting cell-intrinsic mechanisms mediating long-term survival of dormant DTCs; sensitizing dormant DTCs to chemotherapy treatments; and, inhibiting the immune evasion of dormant DTCs, leading to their demise. Various therapeutic approaches, some of which utilize drugs that are already approved, or have been tested in clinical trials and may be considered for repurposing, will be discussed. In addition, clinical evidence for the presence of dormant DTCs will be reviewed, along with potential prognostic biomarkers to enable the identification and stratification of patients who are at high risk of recurrence, and who could benefit from novel dormant DTCs targeting therapies. Finally, we will address the shortcomings of current trial designs for determining activity against dormant DTCs and provide novel approaches.

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Hazards of Recurrence, Second Primary, or Other Tumor at Ten Years After Surgery for Non–Small-Cell Lung Cancer

Cited by 17 publications

References 26 publications

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

Hazard Curves for Tumor Recurrence and Tumor-Related Death Following Esophagectomy for Esophageal Cancer

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells

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