Hawaiinolides E–G, cytotoxic cassane and cleistanthane diterpenoids from the entomogenous fungus Paraconiothyrium hawaiiense

Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids

“…Based on these data, the planar structure of 1 was established as shown in Fig. 1 which is closely resemble to sonomolide B 15 and hawaiinolide F 14 .

Figure 2 1 H— 1 H COSY and key HMBC correlations of compounds 1 , 4 , 5 and 10 .

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“…Deletion of hdaA , which encodes a histone deacetylase (HDAC), has led to the globally pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and the isolation of diverse ten compounds of which four possess new structures, including three tricyclic diterpenes and a novel meroterpenoid derived from the esterification between an anthraquinone and a cassane diterpene 5 . So far, diterpenoids have exhibited diverse structural features and a wide range of interesting biological activities 11 , 12 , such as cytotoxic 13 , 14 , antimicrobial 15 , 16 , anti-inflammatory 17 , and antiviral 18 , 19 , 20 properties, attracting more and more attention.…”

Seven New Drimane-Type Sesquiterpenoids from a Marine-Derived Fungus Paraconiothyrium sporulosum YK-03

“…Verkley proposed that two Coniothyrium species (C. fuckelii and C. sporulosum) should be combined into the genus Paraconiothyrium, and united as P. sporulosum [5,6]. So far, structural diverse terpenoids including brasilamides A-N [7][8][9], hawaiinolides A-G [10,11], epoxyphomalins A-E [12], sporulaminals A-B [13] and six isopimarane diterpenoid glycosides [14], and several polyketides [15][16][17][18][19][20][21][22][23][24][25][26] have been identified from the genus Paraconiothyrium.…”

Identification and characterization of the biotechnological potential of a wild strain of Paraconiothyrium sp

“…Interestingly, the production of the anticancer agent Taxol by P. variabile has also been reported . In addition to the pharmacological potential for human health, both P. brasiliense and P. variabile produce efficient antifungal metabolites in vitro that are effective against phytopathogens, and P. hawaiiense is entomopathogenic, suggesting the potential use of the genus for biocontrol of pests affecting economically important crops. Regarding the secretion of extracellular ligninolytic enzymes, Forootanfar and collaborators purified and characterized an extracellular laccase from P. variabile that is highly capable for the removal of chlorophenolic derivatives and that also effectively decolorizes synthetic dyes .…”

“…8 Studies conducted in the species of the recently described genus Paraconiothyrium have shown their ample biotechnological potential, including antimicrobial activity of mycelium extracts 9 and the production of antioxidants and antiproliferative agents of psoriasis-related cells, the latter two induced by ethyl acetate. 10 Substances with pharmacological activity have been isolated from the genus and characterized as furanones, 7,11 diterpenoids, 12,13 sesquiterpenes, 14,15 and epoxyphomalins, 5 among other types of compounds. Interestingly, the production of the anticancer agent Taxol by P. variabile has Correspondence concerning this article should be addressed to G. V azquez-Marrufo at gvazquezmarrufo@yahoo.com.mx.…”