‘Have we missed reporting adverse drug reactions under Revised National TB Control Programme?’ - A mixed method study in Bengaluru, India

Krishnappa, Lalitha; Gadicherla, Suman; Chidambaram, Priyadarshini; Anuradha, H V; Somanna, Shivaraj Nallur; Naik, Poonam Ramesh; Das, Abinash; Narasimhaiah, Somashekar; Nagaraja, Sharath Burugina

doi:10.1016/j.ijtb.2020.01.003

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…The challenges faced by these institutions are multi-faceted, including human resource constraints, infrastructural deficits, and limited training and research activities. [10][11][12] Addressing these challenges requires a multi-pronged approach, involving not only medical colleges but also policy-makers, funding agencies, and other stakeholders. The lessons drawn from this study can provide a roadmap to strengthen the RNTCP/NTEP integration across medical colleges, ultimately accelerating India's journey towards TB elimination.…”

Section: Discussionmentioning

confidence: 99%

Practices and challenges in implementing tuberculosis program at medical colleges in Karnataka, India

D. Hiremath,

Sharma,

et al. 2023

Int J Community Med Public Health

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Background: The study aimed to evaluate the implementation status of the National Tuberculosis Elimination Program (NTEP) at medical colleges in Karnataka, India, and identify the challenges encountered by the medical college core committee members. Methods: A cross-sectional study was conducted among 14 medical colleges in 2019-20, using a pre-tested, semi-structured questionnaire to collect data on various NTEP components. Results: The implementation status of NTEP activities was categorized as adequate, partially adequate, or inadequate. Results showed that certain activities such as TB notification, DMC infrastructure, TB-HIV coordination, and the formation of the NTEP core committee were adequately implemented. However, challenges such as work overload, lack of dedicated manpower, and salary constraints were encountered. Conclusions: Overall, the medical colleges involved in the study were actively implementing NTEP, but there is still room for improvement to fully optimize the implementation.

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Section: Discussionmentioning

confidence: 99%

Practices and challenges in implementing tuberculosis program at medical colleges in Karnataka, India

D. Hiremath,

Sharma,

et al. 2023

Int J Community Med Public Health

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TB operational research in India – Gaps and pragmatic solutions

Burugina Nagaraja

2024

Indian Journal of Tuberculosis

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Incidence of adverse drug reactions among tuberculosis patients initiated on daily drug regimen in a southern district of Karnataka

Kumar,

Rao,

Maradi

et al. 2024

Perspectives in Clinical Research

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Aim: The study aimed to determine the incidence of adverse drug reactions (ADRs) among newly diagnosed tuberculosis (TB) patients receiving daily drug regimen with fixed-dose combination treatment under the National Tuberculosis Elimination Program. Materials and Methods: A community-based prospective cohort study was carried out in the Udupi district. Over 12 months, all newly diagnosed TB patients of either gender were included from 63 primary health centers and 6 community health centers, and ADRs were recorded by personal interviews. Results: A total of 710 patients were enrolled, among whom 453 (63.8%), were males, and 257 (36.2%) were females. Pulmonary TB was diagnosed among 510 (71.8%) and 200 (28.2%) were extrapulmonary cases. During the intensive phase (IP) of treatment, 480 (67.6%) patients reported at least one ADR and 79 (11.1%) experienced two ADRs during IP and 31 (6.5%) had ADRs during the continuation phase. Out of 480, 140 (29.2%) had gastritis, 132 (27.5%) had vomiting, 105 (21.9%) had nausea, 60 (12.5%) had skin rashes, 27 (5.6%) had drug-induced hepatitis, and 16 (3.3%) had vision problems. Among 480 patients with ADRs, 462 (96.3%) had successful treatment outcomes, the remaining 17 patients (3.5%) died, and one (0.2%) had treatment failure. Conclusions: Adverse events were more common in the 1st few months of treatment than in subsequent months. All mild-to-moderate ADRs were effectively managed, and most had successful treatment outcomes.

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‘Have we missed reporting adverse drug reactions under Revised National TB Control Programme?’ - A mixed method study in Bengaluru, India

Cited by 3 publications

References 4 publications

Practices and challenges in implementing tuberculosis program at medical colleges in Karnataka, India

Practices and challenges in implementing tuberculosis program at medical colleges in Karnataka, India

TB operational research in India – Gaps and pragmatic solutions

Incidence of adverse drug reactions among tuberculosis patients initiated on daily drug regimen in a southern district of Karnataka

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