HAV-induced Acalculous cholecystitis: A case report and literature review

Salajegheh, Faranak; Shafieipour, Sara; Najminejad, Zoher; Pourzand, Pouria; Nakhaie, Mohsen; Jahangiri, Samaneh; Sarmadian, Roham; Gilani, Abolfazl; Rukerd, Mohammad Rezaei Zadeh

doi:10.22541/au.167576236.63535254/v1

Cited by 1 publication

(3 citation statements)

References 38 publications

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“…The most common finding is gallbladder wall thickening greater than 3.5 mm. Suggested mechanisms include the direct effect of viral antigens [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Hepatitis A virus (HAV) causes liver inflammation, resulting in a range of symptoms from mild to severe, including fever, severe fatigue, loss of appetite, abdominal discomfort, nausea and vomiting. However, it is usually a self-limiting disease, especially in childhood [1,2]. HAV is transmitted through physical contact and the fecaloral route when contaminated food or water containing the feces of an infected person is ingested [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, it is usually a self-limiting disease, especially in childhood [1,2]. HAV is transmitted through physical contact and the fecaloral route when contaminated food or water containing the feces of an infected person is ingested [2]. It is a widespread illness, especially in developing countries due to poor hygiene and sanitation practices [3].…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis A virus infection associated with bilateral pleural effusion, ascites, and acalculous cholecystitis in childhood: a case report

Breim,

Roumi Jamal,

Kanaa

et al. 2024

J Med Case Reports

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Background Acute hepatitis A infection is common among children in developing nations. The clinical presentation in children is usually asymptomatic and anicteric, and it is a self-limiting infection. Rarely, it can be associated with extrahepatic complications such as pleural effusion, acalculous cholecystitis, and ascites. Case presentation An 8-year-old middle eastern child presented with abdominal pain, jaundice in the sclera, yellowish color of urine, and poor appetite. In the last two days, abdominal distension developed. After conducting diagnostic investigations, the child was diagnosed with HAV hepatitis associated with bilateral pleural effusion, acalculous cholecystitis, and ascites. He was managed conservatively with vitamin K supplementation and supportive parenteral fluids. After 4 days, clinical improvement was observed. Conclusion Hepatitis A infections presented with extrahepatic manifestations like pleural effusion, acalculous cholecystitis, and ascites are very rare, especially in children. There have been some reports of these manifestations occurring in isolation, but for them to co-exist to our knowledge, this has only been reported in two cases in the literature, and this is the third case with all these three rare complications being presented simultaneously in a single child. Although HAV infection is an asymptomatic and self-limiting viral disease in childhood, it can manifest with rare extrahepatic complications, so pediatricians should be aware of this rare association to avoid unnecessary investigations.

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“…The most common finding is gallbladder wall thickening greater than 3.5 mm. Suggested mechanisms include the direct effect of viral antigens [2,3].…”

Section: Discussionmentioning

confidence: 99%