Hautmetastasen bei viszeralen Malignomen

Abstract

The objective of our study was to get epidemiological data in the region of Aarau, Switzerland, about the frequency of cutaneous metastases from visceral malignancies. With a computer search we analyzed all patients with skin metastases from visceral malignancies who had attended our clinic between January 1, 1998, and December 31, 2003. Out of 19 491 patients, 37 had cutaneous metastases from visceral tumours (0,19%): 25 women (67.5%) and 12 men (32.5%) were affected. 19 had breast cancer (51%), 8 sarcomas (21%), 2 leukemia (5%), 2 colorectal cancer, and one each ovary carcinoma, bronchial cancer, prostate cancer, malignant histiocytoma and Non-Hodgkin lymphoma (3%). In 24 cases the primary malignancy was known (65%). In 35% cutaneous metastases were diagnosed at the same time as the primary tumour. Primary malignancies were diagnosed in 54% within the age range of 50-70 years, and 65% of cutaneous metastases were diagnosed within the age range of 50-80 years. In 51% skin metastases were the first site of dissemination. In 49% other known metastases were present (5% locoregional, 38% lymph nodes, 3% brain, 3% lung, 3% liver). Our study documents that cutaneous metastases from visceral malignancies are rare. However, early diagnosis has an impact concerning further treatment and prognosis.

Differences in the Molecular Profile between Primary Breast Carcinomas and Their Cutaneous Metastases

“…Thus, Lookingbill et al [ 25 ] found that only 6.3% of patients with BC had cutaneous involvement at the time of diagnosis of the primary tumor. More recently, Johnson et al [ 24 ] reported that approximately 13.7% of the patients in the 9 retrospective series reviewed [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] had a skin lesion before or simultaneously with the diagnosis of BC. Supporting these observations, we found that 18.2% of patient in the present series debuted with skin involvement.…”

Cutaneous Metastasis from Internal Malignancies: The Revealing Role of the Skin

“…The authors emphasised the different clinical and histopathological features that breast carcinoma can adopt in a metastatic setting. Second, lung carcinoma (the first cause of metastatic lesions in males over 40 years of age) may manifest earlier in the metastatic setting before the primary tumour is diagnosed, an aspect emphasised in one study [4]. In terms of histotype, approximately 50% of the cases originate from non-small cell carcinomas, whereas 30% of the cases originate from small-cell lung carcinomas [5].…”